Human Tumor Atlas Network: Data Coordinating Center Extension

人类肿瘤图谱网络：数据协调中心扩展

• 批准号: 10818705
• 负责人: Ethan Cerami
• 金额: $ 200.72万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-04 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10818705
• 关键词: Acceleration; Archives; Atlases; Cells; Clinical; Cloud Computing; Collaborations; Communities; Coupled; Dana-Farber Cancer Institute; Data; Data Analyses; Data Commons; Data Coordinating Center; Data Scientist; Development; Documentation; Education and Outreach; Educational Materials; Ensure; Evolution; Fostering; Funding; Genomics; Human; Image; Immunogenomics; Individual; Institution; Intuition; Location; Malignant Neoplasms; Memorial Sloan-Kettering Cancer Center; Molecular; Patients; Performance; Prevention strategy; Procedures; Research; Research Personnel; Research Support; Resistance development; Resources; Services; Slide; Synapses; Systems Biology; Technology; Translational Research; Visualization; Work; anticancer research; application programming interface; cBioPortal; cancer genomics; cancer therapy; centralized portal; cloud based; cloud platform; community building; community involvement; data acquisition; data dissemination; data hub; data management; data portal; data resource; data standards; data submission; data visualization; digital; human genome sequencing; improved; large scale data; novel; open source; operation; outreach program; pathology imaging; radiological imaging; shared database; software development; success; tool; treatment strategy; tumor; tumor progression; tumorigenesis; web portal; working group

Project Summary/Abstract We propose to continue managing the operations of the data coordinating center (DCC) for the Human Tumor Atlas Network (HTAN) with responsibilities for managing, curating, and disseminating the data and resources generated through this network. We have provided, and will continue to provide, key services to organize and support the Research Centers that comprise the network, and foster a community based on collaboration, transparency, and sharing. Our primary scientific objective is to accelerate the discovery of mechanisms governing tumorigenesis, progression, and evolution, which will lead to improved prevention and treatment strategies for patients. We aim to achieve this by providing technology services coupled with best practices to expedite data acquisition and dissemination to HTAN researchers, as well as the broader scientific community. HTAN data is now available via the HTAN Data Portal, the Synapse platform, Minerva, CellXGene, cBioPortal, Google BigQuery, the NCI Cancer Research Data Service (CDS) and the NCI Image Data Commons (IDC). We will continue to release HTAN data to the wider scientific community and further develop visualization, annotation, and analysis tools in order to meet the needs of HTAN and the diverse cancer research community – including data scientists and statisticians to biologists and clinicians – as new types of data are generated.

项目总结/摘要 我们建议继续管理数据协调中心（DCC）的运营， 人类肿瘤图谱网络（HTAN），负责管理，策划， 传播通过该网络产生的数据和资源。我们提供了， 将继续提供关键服务，以组织和支持研究中心， 组成网络，并培养一个基于协作、透明和 共享我们的主要科学目标是加速发现 肿瘤的发生、发展和演变，这将导致预防和治疗的改善 患者的策略。我们的目标是通过提供技术服务， 加快数据采集和向HTAN研究人员传播的最佳做法，以及 更广泛的科学界。HTAN数据现在可以通过HTAN数据门户网站获得， Synapse平台、Minerva、CellXGene、cBioPortal、Google BigQuery、NCI癌症研究 数据服务（CDS）和NCI图像数据共享（IDC）。我们将继续发布 HTAN数据提供给更广泛的科学界，并进一步开发可视化、注释和 分析工具，以满足HTAN和不同癌症研究社区的需求- 包括数据科学家和统计学家到生物学家和临床医生-因为新类型的数据正在 生成的.