MEDICINAL CHEMISTRY CONSULTING SERVICES

药物化学咨询服务

• 批准号: 10813676
• 负责人: GIAN ARALDI
• 金额: $ 3.96万
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-27 至 2023-07-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10813676
• 关键词: Address; Chemical Structure; Chemistry; Clinical Research; Collaborations; Contractor; Data; Development; Electronic Mail; Feedback; Helping to End Addiction Long-term; Individual; Lead; Methodology; Pharmaceutical Chemistry; Principal Investigator; Process; Reporting; Research; Research Contracts; Role; Services; Strategic Planning; Telephone; Testing; United States National Institutes of Health; Visit; design; drug development; drug discovery; lead optimization; member; programs; symposium

This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management; pain The medicinal chemistry Consultant will be expected to provide executive (senior scientific)- level Medicinal Chemistry expertise and contribute feedback and guidance on projects to the NIH and to LDT members through video/tele conference and by email. The role of the medicinal chemistry Consultant may include but is not limited to the following responsibilities and tasks: 1. Offer input on project milestones, target product profiles, and testing funnels. 2. Provide feedback on chemical structures and processes proposed by a chemistry service Contractor for each round of SAR. 3. Evaluate SAR data on a weekly or biweekly basis. 4. Evaluate the potential tractability (including surrounding IP space) of a chemical structure for medicinal chemistry. Specific consulting responsibilities will depend on the expertise of the individual Consultant and the needs of individual projects. 5. In partnership with other Consultants, Contractors, and the NIH staff, advise, strategically plan, and manage medicinal chemistry programs to facilitate exploratory chemistry, hit-to-lead, lead optimization, IND enabling, and clinical studies. 6. Serve as the medicinal chemistry expert in order to identify potential drug discovery and development challenges and suggest strategies to address these challenges. 7. Collaborate on design of investigative studies in support of NIH drug discovery and development projects. 8. Review Medicinal Chemistry sections of regulatory filings provided by CROs (Contract Research Organizations) or PIs (Principal Investigators). 9. Collaborate on the design of investigative studies in support of development compounds. 10. At the request of program manager, accompany NIH staff on visits to CRO facilities that provide research services to NIH programs including the NIH Helping to End Addiction Long-term (HEAL) and NIH Blueprint Neurotherapeutics Network. Assist NIH staff in inspecting CRO facilities, and prepare and submit trip reports to BPN and/or HEAL program managers if requested. 11. Discuss appropriateness of CRO’s proposed methodology. 12. Facilitate Lead Development Team discussions via telephone and email regarding assigned medicinal chemistry efforts.

这项研究是NIH帮助结束长期成瘾（HEAL）计划的一部分，旨在加速科学解决方案，以了解疼痛的基础并加强临床疼痛管理; 药物化学顾问应提供执行（高级科学）- 水平的药物化学专业知识，并为项目提供反馈和指导， NIH和LDT成员通过视频/电话会议和电子邮件。药物的作用 化学顾问可能包括但不限于以下职责和任务： 1.提供项目里程碑、目标产品概况和测试漏斗的输入。 2.提供化学结构和化学过程的反馈 每轮SAR的服务承包商。 3.每周或每两周评估SAR数据。 4.评估化学品的潜在易处理性（包括周围IP空间） 药物化学结构。具体的咨询责任将取决于 个别顾问的专业知识和个别项目的需要。 5.与其他顾问，承包商和NIH工作人员合作，建议， 战略规划，并管理药物化学计划，以促进探索 化学、电极导线命中、电极导线优化、IND启用和临床研究。 6.作为药物化学专家，以确定潜在的药物发现， 发展挑战，并提出应对这些挑战的战略。 7.合作设计调查研究，支持NIH药物发现， 发展项目。 8.审查CRO提供的监管文件的药物化学部分（合同 研究组织）或PI（主要研究者）。 9.合作设计调查研究，以支持开发化合物。 10.应项目经理的要求，陪同NIH工作人员访问CRO设施， 为NIH项目提供研究服务，包括NIH帮助结束成瘾 长期（HEAL）和NIH蓝图神经治疗网络。协助NIH工作人员 检查CRO设施，准备并向BPN和/或HEAL提交出差报告 项目经理如有要求 11.讨论CRO拟定方法的适当性。 12.通过电话和电子邮件促进领导开发团队讨论 分配的药物化学工作。