MEDICINAL CHEMISTRY CONSULTING SERVICES

这项研究是美国国立卫生研究院帮助结束成瘾长期(Heal)计划的一部分，该计划旨在加快科学解决方案，以了解疼痛的基础并加强临床疼痛管理； 预计药物化学顾问将提供行政(高级科学)- 提高药物化学专业知识水平，并就项目提供反馈和指导 NIH和通过视频/电话会议和电子邮件发送给LDT成员。医药学的作用 化学顾问可包括但不限于以下职责和任务： 1.提供有关项目里程碑、目标产品简介和测试漏斗的意见。 2.就化学提出的化学结构和过程提供反馈 每一轮特别行政区的服务承包商。 3.每周或每两周评估一次SAR数据。 4.评估化学品的潜在可处理性(包括周围的IP空间) 用于药物化学的结构。具体的咨询责任将取决于 个别顾问的专业知识和个别项目的需要。 5.与其他顾问、承包商和NIH工作人员合作， 战略性规划和管理药物化学项目，促进探索性研究 化学、Hit-to-Lead、Lead优化、Ind Enabling和临床研究。 6.担任药物化学专家，以确定潜在的药物发现和 发展挑战，并提出应对这些挑战的战略。 7.合作设计调查性研究，以支持NIH药物发现和 发展项目。 8.审查CRO(合同)提供的法规文件中的药物化学部分 研究机构)或PI(首席调查员)。 9.合作设计调查性研究，以支持开发化合物。 10.应项目经理的要求，陪同NIH工作人员参观CRO设施， 为包括NIH在内的NIH项目提供研究服务，帮助戒除成瘾 长期(REAL)和美国国立卫生研究院神经治疗蓝图网络。协助NIH工作人员 检查CRO设施，准备行程报告并提交给BPN和/或CORE 如有要求，请联系项目经理。 11.讨论CRO提出的方法的适当性。 12.通过电话和电子邮件促进销售线索开发团队就以下问题进行讨论 指定的药物化学工作。

This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to understand the basis of pain and enhance clinical pain management; pain The medicinal chemistry Consultant will be expected to provide executive (senior scientific)- level Medicinal Chemistry expertise and contribute feedback and guidance on projects to the NIH and to LDT members through video/tele conference and by email. The role of the medicinal chemistry Consultant may include but is not limited to the following responsibilities and tasks: 1. Offer input on project milestones, target product profiles, and testing funnels. 2. Provide feedback on chemical structures and processes proposed by a chemistry service Contractor for each round of SAR. 3. Evaluate SAR data on a weekly or biweekly basis. 4. Evaluate the potential tractability (including surrounding IP space) of a chemical structure for medicinal chemistry. Specific consulting responsibilities will depend on the expertise of the individual Consultant and the needs of individual projects. 5. In partnership with other Consultants, Contractors, and the NIH staff, advise, strategically plan, and manage medicinal chemistry programs to facilitate exploratory chemistry, hit-to-lead, lead optimization, IND enabling, and clinical studies. 6. Serve as the medicinal chemistry expert in order to identify potential drug discovery and development challenges and suggest strategies to address these challenges. 7. Collaborate on design of investigative studies in support of NIH drug discovery and development projects. 8. Review Medicinal Chemistry sections of regulatory filings provided by CROs (Contract Research Organizations) or PIs (Principal Investigators). 9. Collaborate on the design of investigative studies in support of development compounds. 10. At the request of program manager, accompany NIH staff on visits to CRO facilities that provide research services to NIH programs including the NIH Helping to End Addiction Long-term (HEAL) and NIH Blueprint Neurotherapeutics Network. Assist NIH staff in inspecting CRO facilities, and prepare and submit trip reports to BPN and/or HEAL program managers if requested. 11. Discuss appropriateness of CRO’s proposed methodology. 12. Facilitate Lead Development Team discussions via telephone and email regarding assigned medicinal chemistry efforts.