Evaluating the use of long-acting antiretroviral treatment for HIV during community re-entry: Addressing community and structural barriers

评估重返社区期间艾滋病毒长效抗逆转录病毒治疗的使用情况：解决社区和结构性障碍

• 批准号: 10818986
• 负责人: GEORGIA Doris TOMARAS
• 金额: $ 50.67万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10818986
• 关键词: Address; Adherence; Administrator; Area; Back; Baltimore; Communities; Community Health Aides; Community Services; Consolidated Framework for Implementation Research; County; Data; Delphi Study; Development; Employment; Environment; Epidemic; FDA approved; Foundations; Funding; Future; Geographic Locations; Guidelines; HIV; HIV Infections; Health; Health Insurance; Health Services; Health Services Accessibility; Housing; Imprisonment; Individual; Injectable; Intervention; Interview; Intramuscular Injections; Investigation; Justice; Location; Logic; Maps; Medical Staff; Medicine; Mental Health; Mental disorders; Methodology; Methods; Mid-Atlantic Region; Modality; Modeling; Oral; Patients; Persons; Pharmaceutical Preparations; Population; Positioning Attribute; Poverty; Practice Guidelines; Process; Protocols documentation; Provider; Public Health; Randomized, Controlled Trials; Regimen; Relapse; Research; Research Support; Risk; Series; Services; Site; Social Sciences; Substance Use Disorder; Surveys; Theoretical model; Time; Training; Treatment outcome; Unemployment; United States; Vulnerable Populations; Walking; Washington; Work; antiretroviral therapy; community reentry; design; experience; high risk population; housing instability; implementation research; implementation science; improved; innovation; opioid use disorder; peer; pilot test; poor health outcome; service providers; social; substance use; viral rebound

Abstract Persons who experience incarceration are disproportionately impacted by HIV infection. The time of release from carceral settings, known as community re-entry, is a period of particularly high risk for persons with HIV. During this time, people are at an increased risk of viral rebound due to poor ART adherence, substance use relapse, inability to engage with community HIV providers, inability to fill ART prescriptions, and competing needs in the chaotic environment to which individuals return. Long-acting injectable (LAI) ART is a new alternative to help overcome the challenges of adhering to a daily regimen of oral medication. However, little is known about how best to develop and optimize LAI ART interventions in this population. Therefore, we propose exploratory implementation research that will provide additional preliminary data to enhance our understanding of LAI ART implementation in diverse Ending the HIV Epidemic (EHE) areas in the mid-Atlantic region: Prince Georges County, MD; and Washington, DC. Using the Consolidated Framework for Implementation Research—a theoretical model that guides investigation into the factors that influence implementation, we propose interviewing stakeholders in each of the above EHE areas and conducting a Delphi study. Specific focus will be placed on linkage to a broad array of health services (e.g., mental health, substance use, the need for peer or community health worker services) and the structural barriers that might be present in each location (health insurance, housing, employment, poverty). Our specific aims are to: 1) identify how to optimize future LAI ART interventions in community re-entry populations by interviewing 15 stakeholders at each site (total n=45), and 2) co-produce best practice guidelines for future LAI ART interventions by conducting a Delphi study with 30 experts. The proposed project maps onto the objectives of the funding announcement in that we will conduct implementation research to develop a LAI intervention that addresses multi-level factors that are key to facilitating linkage to innovative HIV treatment modalities. Findings from the supplement supported research will be the foundation of a future R01 application and, importantly, will be shared back with our EHE implementation, governmental, and community partners at each EHE site.

摘要

项目成果

A response adaptive randomization platform trial for efficient evaluation of Ebola virus treatments: A model for pandemic response.

• DOI: 10.1177/1740774515621721
• 发表时间: 2016-02
• 期刊: Clinical trials (London, England)
• 作者: Berry SM;Petzold EA;Dull P;Thielman NM;Cunningham CK;Corey GR;McClain MT;Hoover DL;Russell J;Griffiss JM;Woods CW
• 通讯作者: Woods CW

Functional Homology for Antibody-Dependent Phagocytosis Across Humans and Rhesus Macaques.

• DOI: 10.3389/fimmu.2021.678511
• 发表时间: 2021
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Pollara J;Tay MZ;Edwards RW;Goodman D;Crowley AR;Edwards RJ;Easterhoff D;Conley HE;Hoxie T;Gurley T;Jones C;Machiele E;Tuyishime M;Donahue E;Jha S;Spreng RL;Hope TJ;Wiehe K;He MM;Moody MA;Saunders KO;Ackerman ME;Ferrari G;Tomaras GD
• 通讯作者: Tomaras GD

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• DOI: 10.1016/j.ctarc.2020.100213
• 发表时间: 2020
• 期刊: Cancer treatment and research communications

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• DOI: 10.1080/17441692.2021.1951801
• 发表时间: 2022-12
• 期刊: Global public health
• 影响因子: 3.3
• 作者: Schmidt CN;Puffer ES;Broverman S;Warren V;Green EP
• 通讯作者: Green EP

A Randomized Trial of an Online Risk Reduction Intervention for Young Black MSM.

• DOI: 10.1007/s10461-018-2289-9
• 发表时间: 2019-05
• 期刊: AIDS and behavior
• 影响因子: 4.4
• 作者: Hightow-Weidman LB;LeGrand S;Muessig KE;Simmons RA;Soni K;Choi SK;Kirschke-Schwartz H;Egger JR
• 通讯作者: Egger JR