Intersubject Synchrony in Neural and Behavioral Representations of Social Uncertainty Among Adults and Adolescents

成人和青少年社会不确定性的神经和行为表征的主体间同步性

• 批准号: 10828675
• 负责人: William John Mitchell
• 金额: $ 3.44万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-20 至 2025-09-19
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10828675
• 关键词: Adolescence; Adolescent; Adolescent Development; Adult; Affective; Anxiety; Anxiety Disorders; Applications Grants; Attention; Automobile Driving; Behavioral; Belief; Characteristics; Cognition; Cognitive; Complex; Computing Methodologies; Crime; Data; Decision Making; Dedications; Development; Drama; Emotional; Emotions; Evaluation; Exhibits; Experimental Designs; Familiarity; Fellowship; Functional Magnetic Resonance Imaging; Future; Goals; Guilt; Human; Individual; Instruction; Judgment; Knowledge; Life Cycle Stages; Literature; Measurement; Measures; Memory; Mental Depression; Mentorship; Methods; Mood Disorders; Moods; Neurosciences Research; Outcome; Participant; Pattern; Peer Pressure; Perception; Phase; Population; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Predisposition; Process; Psyche structure; Research; Research Design; Research Personnel; Research Project Grants; Risk Taking; Sampling; Severities; Social Development; Source; Stimulus; Stressful Event; Techniques; Time; Training; Trust; Uncertainty; Vulnerable Populations; Work; age related; autism spectrum disorder; clinically relevant; clinically significant; computational neuroscience; cost; emotion dysregulation; expectation; experience; luminance; multimodality; neural; neural circuit; neural model; neural recruitment; neuroimaging; neuromechanism; novel; pre-doctoral; response; skills; social; social cognition; social neuroscience; social situation; social stressor; theories

Project Summary Uncertainty is an often pervasive, stressful experience that arises when making judgments about others' beliefs, intentions, or emotions (i.e., ambiguous social situations). Excessive uncertainty can have pernicious effects upon memory, mood, and physical and mental outcomes. Yet, we understand little of how judgments of social certainty form over time, the neural circuitry underlying these judgments, and how these judgments meaningfully differ from non-social uncertainty sources (e.g., calculations, perceptions). Uncertainty is featured in every developmental stage but adolescents and adults differ in their appraisals of and responses to ambiguity; both social and non-social. Traditional univariate neuroimaging analyses, which compare average magnitudes of activation across broad neural regions, are unresponsive to the subtle pattern differences that characterize complex social cognition. Novel multivariate techniques, such as intersubject correlations (ISC), applied to dynamic, feature-rich, and ecologically-valid sources of social ambiguity are crucial for understanding fundamental aspects of social cognition but have not yet been applied to answer these important questions. F99 Phase: My proposed pre-doctoral project uses a novel study design in which adult participants continuously rate their certainty of a given social (e.g., a character's innocence or guilt) and non-social (e.g., frame luminance) outcome while observing long-form narrative video stimuli (i.e., 45 min crime drama) during fMRI. This yields a continuous time course of concurrently-recorded neural and behavioral data which can be analyzed via ISC to determine the neural circuitry commonly implicated in uncertainty judgment formation among normative adult populations. Interdomain neural-behavioral synchrony can underscore how social and non-social certainty judgment formation mechanisms differ. Defining normative adult neural uncertainty responses provides a crucial comparison to vulnerable populations with pronounced uncertainty responses, including autism spectrum, anxiety, and mood disorders. Training during this phase includes instruction in computational methods relevant to the neuroscience of social decision-making and neurodevelopmental theory to prepare for the K00 Phase. K00 Phase: This phase extends my pre-doctoral research by applying the F99 Phase study design to adolescent populations. This approach could identify whether adults and adolescents are generally relying on distinct or similar neural circuitry to assess the same stimuli and inform subjective indicators of uncertainty (i.e., behavioral ratings). Adolescence is a period marked by intense attention towards social others. The presence of ambiguous social stressors during this period predicts susceptibility to and severity of anxiety and depression into adulthood. Thus, how social uncertainty is processed has notable implications for researchers working at any later developmental stage. The training plan in this phase of the proposal will focus on developing expertise in the developmental social neuroscience literature, computational methods that can be applied to developmental social neuroscience research, and mentorship skills to establish a diverse, inclusive independent research lab.

项目摘要 不确定性是一种普遍存在的压力体验，在对他人的信仰做出判断时会出现， 意图或情绪（即，模糊的社会状况）。过度的不确定性会产生有害的影响 对记忆、情绪、身体和精神的影响。然而，我们对社会的判断是如何进行的却知之甚少。 确定性随着时间的推移而形成，这些判断背后的神经回路，以及这些判断如何有意义 不同于非社会不确定性来源（例如，计算、感知）。不确定性在每个 发展阶段，但青少年和成年人在他们的评价和反应歧义; 社交和非社交。传统的单变量神经影像学分析，比较了 在广泛的神经区域激活，是不响应的微妙的模式差异， 复杂的社会认知新的多变量技术，如受试者间相关性（ISC），适用于 动态的、特征丰富的、生态上有效的社会模糊性来源对于理解 社会认知的基本方面，但尚未应用于回答这些重要问题。 F99阶段：我提出的博士前项目使用了一种新颖的研究设计，其中成年参与者连续 评定他们对给定社交的确定性（例如，角色的无罪或有罪）和非社会性（例如，帧亮度） 观察长形式叙事视频刺激时的结果（即，45分钟的犯罪剧）。这产生 同时记录的神经和行为数据的连续时间过程，可以通过ISC进行分析， 确定正常成年人不确定性判断形成的神经回路 人口。域间神经行为同步可以强调社会和非社会确定性 判断形成机制不同。定义规范的成人神经不确定性反应提供了一个关键的 与具有明显不确定性反应的弱势群体（包括自闭症谱系）相比， 焦虑和情绪障碍在这个阶段的培训包括相关的计算方法的指导 到社会决策的神经科学和神经发育理论，为K 00阶段做准备。 K 00阶段：该阶段通过将F99阶段研究设计应用于青少年，扩展了我的博士前研究。 人口。这种方法可以确定成年人和青少年是否普遍依赖于不同的或 类似的神经电路来评估相同的刺激并告知不确定性的主观指标（即，行为 评级）。青春期是一个对社会其他人高度关注的时期。模棱两可的存在 这一时期的社会压力因素预示着成年后对焦虑和抑郁的易感性和严重程度。 因此，如何处理社会不确定性对研究人员在任何以后的研究都有显着的意义。 发育阶段建议书这一阶段的培训计划将侧重于发展以下方面的专门知识： 发展社会神经科学文献，可应用于发展的计算方法， 社会神经科学研究和指导技能，以建立一个多元化，包容性的独立研究实验室。