7/8 NADIA U01 Recovery of Adolescent Alcohol Disruption of Basal Forebrain-Cortical Projection Circuits
7/8 NADIA U01 青少年酒精恢复对基底前脑皮质投射回路的破坏
基本信息
- 批准号:10831641
- 负责人:
- 金额:$ 15.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-09-01 至 2025-08-31
- 项目状态:未结题
- 来源:
- 关键词:AbstinenceAccelerationAcetylcholineAcuteAdolescenceAdolescentAdultAlcohol consumptionAlcoholsAmyloid beta-ProteinBindingBrainBrain PathologyCell DeathChronicData ScienceDevelopmentEducational process of instructingEquityEthanolExposure toFacultyFunctional disorderGrantHealthHippocampusMediatingMediatorMentorsModelingNGFR ProteinNerve Growth FactorsPathologicPhenotypePositioning AttributeProcessPublicationsRecoveryResearchResearch ActivityResearch PersonnelRodent ModelStructureTrainingTraining SupportWritingadolescent alcohol exposureadolescent binge drinkingalcohol exposurealcohol use disorderbasal forebrainbinge drinkingcareercareer developmentcellular pathologycholinergiccognitive functiondementia riskexperiencegamma-Aminobutyric Acidin vivoinnovationneurogenesisneuropathologynovelparent projectpathological agingreceptorresponsetenure track
项目摘要
Project Summary
The requested Research Supplement to Promote Diversity in Health-Related Research will
support the training of an outstanding Early Investigator developing an independent research
career in the field of developmental alcohol and later brain pathology. Heavy alcohol consumption
during adolescence is associated with persistent changes in brain structure, connectivity, and
adult hippocampal and cortical-mediated cognitive functions. Enduring pathological changes
consistently observed in rodent models of adolescent ethanol exposure (Adolescent Intermittent
Ethanol; AIE) include reductions of nerve growth factor, suppression of the cholinergic
phenotypes, changes in activity-dependent acetylcholine release, and blunted hippocampal
neurogenesis. The current Supplement to Promote Diversity extends the research scope of the
Parent Project by examining whether AIE increases amyloid-β (Aβ) hippocampal levels, serving
as a synergistic mediator of cellular pathology. At high levels, Aβ also binds to the p75
neurotrophin receptor, contributes to cell death, and may predispose the brain toward an
accelerated pathological response. Given that pathological Aβ release is activity-dependent, a
novel γ-aminobutyric-acid type-A receptor modulator (GABAAα5) will be used to correct AIE-
induced Aβ dysfunction. These research activities will expand the research experiences and
scientific scope of the candidate. Specifically, the research plan will expose the candidate to
developmental ethanol perspectives and several innovative technical approaches (in vivo brain
activity; programming, data science essentials). The mentoring plan will entail training in
equitable and inclusive mentoring and teaching, effective publication and grant writing, and
networking with leading researchers with expertise in developmental alcohol exposure and adult
neuropathology. Critically, the candidate will be exposed to an academic model that blends
teaching, mentoring, and research. Career development and mentoring plans are cohesively
devised to facilitate a successful transition to a tenure-track faculty position by the candidate.
项目摘要
所要求的促进卫生相关研究多样性的研究补编将
支持培养一名优秀的早期研究者,
在酒精发育和后来的大脑病理学领域的职业生涯。重度饮酒
在青春期与大脑结构的持续变化,连接,
成年海马和皮质介导的认知功能。持久病变
在青少年乙醇暴露的啮齿动物模型中一致观察到(青少年间歇性
乙醇; AIE)包括减少神经生长因子、抑制胆碱能
表型,活动依赖性乙酰胆碱释放的变化,以及钝性海马
神经发生目前的《促进多样性补编》扩大了
父母项目通过检查AIE是否增加淀粉样蛋白-β(Aβ)海马水平,
作为细胞病理学的协同介质。在高水平下,Aβ还与p75结合,
神经营养素受体,有助于细胞死亡,并可能使大脑倾向于
加速病理反应。鉴于病理性Aβ释放是活性依赖性的,
新的γ-氨基丁酸A型受体调节剂(GABAAα5)将用于纠正AIE,
诱发Aβ功能障碍。这些研究活动将扩大研究经验,
候选人的科学范围。具体来说,研究计划将使候选人接触到
乙醇的发展前景和一些创新的技术方法(在体内脑
活动;编程,数据科学基础)。辅导计划将包括以下方面的培训:
公平和包容的指导和教学,有效的出版和赠款写作,以及
与具有发育性酒精暴露和成人酒精暴露方面专业知识的领先研究人员建立联系
神经病理学至关重要的是,候选人将接触到一个学术模式,
教学指导和研究职业发展和指导计划是连贯的
旨在促进候选人成功过渡到终身教职职位。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Lisa M Savage其他文献
Lisa M Savage的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Lisa M Savage', 18)}}的其他基金
7/8 NADIA U01 Recovery of Adolescent Alcohol Disruption of Basal Forebrain-Cortical Projection Circuits
7/8 NADIA U01 青少年酒精恢复对基底前脑皮质投射回路的破坏
- 批准号:
10247815 - 财政年份:2020
- 资助金额:
$ 15.29万 - 项目类别:
7/8 NADIA U01 Recovery of Adolescent Alcohol Disruption of Basal Forebrain-Cortical Projection Circuits
7/8 NADIA U01 青少年酒精恢复对基底前脑皮质投射回路的破坏
- 批准号:
10688064 - 财政年份:2020
- 资助金额:
$ 15.29万 - 项目类别:
7/8 NADIA U01 Recovery of Adolescent Alcohol Disruption of Basal Forebrain-Cortical Projection Circuits
7/8 NADIA U01 青少年酒精恢复对基底前脑皮质投射回路的破坏
- 批准号:
10473730 - 财政年份:2020
- 资助金额:
$ 15.29万 - 项目类别:
Cortical Biobehavioral Disruption after Thiamine Deficiency and Chronic Alcohol
硫胺素缺乏和长期饮酒后皮质生物行为破坏
- 批准号:
8900087 - 财政年份:2014
- 资助金额:
$ 15.29万 - 项目类别:
Exercise recovers cholinergic dysfunction through neurotrophin modulation
运动通过神经营养素调节恢复胆碱能功能障碍
- 批准号:
8768919 - 财政年份:2014
- 资助金额:
$ 15.29万 - 项目类别:
Cortical Biobehavioral Disruption after Thiamine Deficiency and Chronic Alcohol
硫胺素缺乏和长期饮酒后皮质生物行为破坏
- 批准号:
8696330 - 财政年份:2014
- 资助金额:
$ 15.29万 - 项目类别:
Exercise recovers cholinergic dysfunction through neurotrophin modulation
运动通过神经营养素调节恢复胆碱能功能障碍
- 批准号:
8846694 - 财政年份:2014
- 资助金额:
$ 15.29万 - 项目类别:
Cortical Biobehavioral Disruption after Thiamine Deficiency and Chronic Alcohol
硫胺素缺乏和长期饮酒后皮质生物行为破坏
- 批准号:
9210578 - 财政年份:2014
- 资助金额:
$ 15.29万 - 项目类别:
Administrative Supplement: Cortical Biobehavioral disruption after thiamine deficiency and chronic alcohol
行政补充:硫胺素缺乏和长期饮酒后皮质生物行为破坏
- 批准号:
9234793 - 财政年份:2014
- 资助金额:
$ 15.29万 - 项目类别:
Main Research Component 2: Binge-type alcohol exposure during adolescence alters the septohippocampal circuit during advanced aging
主要研究部分 2:青春期期间的暴饮暴食会改变晚期衰老过程中的隔海马回路
- 批准号:
10686844 - 财政年份:2009
- 资助金额:
$ 15.29万 - 项目类别:
相似海外基金
SHINE: Origin and Evolution of Compressible Fluctuations in the Solar Wind and Their Role in Solar Wind Heating and Acceleration
SHINE:太阳风可压缩脉动的起源和演化及其在太阳风加热和加速中的作用
- 批准号:
2400967 - 财政年份:2024
- 资助金额:
$ 15.29万 - 项目类别:
Standard Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328975 - 财政年份:2024
- 资助金额:
$ 15.29万 - 项目类别:
Continuing Grant
EXCESS: The role of excess topography and peak ground acceleration on earthquake-preconditioning of landslides
过量:过量地形和峰值地面加速度对滑坡地震预处理的作用
- 批准号:
NE/Y000080/1 - 财政年份:2024
- 资助金额:
$ 15.29万 - 项目类别:
Research Grant
Market Entry Acceleration of the Murb Wind Turbine into Remote Telecoms Power
默布风力涡轮机加速进入远程电信电力市场
- 批准号:
10112700 - 财政年份:2024
- 资助金额:
$ 15.29万 - 项目类别:
Collaborative R&D
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328973 - 财政年份:2024
- 资助金额:
$ 15.29万 - 项目类别:
Continuing Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328972 - 财政年份:2024
- 资助金额:
$ 15.29万 - 项目类别:
Continuing Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
- 批准号:
2332916 - 财政年份:2024
- 资助金额:
$ 15.29万 - 项目类别:
Standard Grant
Collaborative Research: A new understanding of droplet breakup: hydrodynamic instability under complex acceleration
合作研究:对液滴破碎的新认识:复杂加速下的流体动力学不稳定性
- 批准号:
2332917 - 财政年份:2024
- 资助金额:
$ 15.29万 - 项目类别:
Standard Grant
Collaborative Research: FuSe: R3AP: Retunable, Reconfigurable, Racetrack-Memory Acceleration Platform
合作研究:FuSe:R3AP:可重调、可重新配置、赛道内存加速平台
- 批准号:
2328974 - 财政年份:2024
- 资助金额:
$ 15.29万 - 项目类别:
Continuing Grant
Radiation GRMHD with Non-Thermal Particle Acceleration: Next-Generation Models of Black Hole Accretion Flows and Jets
具有非热粒子加速的辐射 GRMHD:黑洞吸积流和喷流的下一代模型
- 批准号:
2307983 - 财政年份:2023
- 资助金额:
$ 15.29万 - 项目类别:
Standard Grant