Frontocortical representations of amygdala-mediated learning under uncertainty

不确定性下杏仁核介导的学习的额皮质表征

基本信息

项目摘要

Project Abstract Learning is one of the essential building blocks of cognition. Individuals with mental health conditions, such as bipolar disorders and schizophrenia, often show symptoms related to learning. A great deal of evidence exists indicating that the orbitofrontal cortex (OFC) and anterior cingulate cortex (ACC) are both heavily involved in flexible learning under uncertainty, with the basolateral amygdala (BLA) sending robust bidirectional connections to both cortical structures. I hypothesize that BLA provides OFC and ACC with dissociable signals that delineate a difference in the expected reward and what was received, vital information for adaptive learning. In Aim 1, rats will be tested on a novel, dynamic, restless bandit task for flexible learning under different probabilistic schedules where the reward contingencies switch within the session. While rats perform this task in some sessions, we will chemogenetically inhibit BLA. A subset of these rats will also express GCaMP6f in OFC and GRIN lenses directly in this region so that we can use miniscopes to record calcium traces while the freely-moving rat learns. In parallel Aim 2, rats learning on the same task will instead have BLA on- or off-line while I record calcium traces in ACC. These approaches will allow us to study how the uncertainty representations in OFC and ACC differentially depend on BLA input. My central hypothesis is that OFC and ACC use BLA-supplied information differently: OFC receives information from BLA that is needed to detect first reversals and setting future adjustments, whereas ACC uses information from BLA to approximate changes in probabilities over time.
项目摘要 学习是认知的基本组成部分之一。有心理健康问题的人,如 躁郁症和精神分裂症,经常表现出与学习有关的症状。有大量证据表明 这表明眶额皮层(OFC)和前扣带皮层(ACC)都严重参与了 不确定性下的灵活学习,基底外侧杏仁核(BLA)发送强大的双向 连接到两个皮层结构我推测BLA为OFC和ACC提供了可分离的信号 这些信息描述了预期奖励和获得奖励之间的差异, 学习在目标1中,大鼠将在一个新的,动态的,不安分的强盗任务中进行测试,以在 不同的概率时间表,其中奖励意外事件在会话内切换。当老鼠表演的时候 在某些阶段,我们将化学抑制BLA。这些老鼠中的一部分也会表达 OFC和GRIN晶状体中的GCaMP6f直接位于该区域,以便我们可以使用微型镜记录钙 而自由移动的老鼠则在学习。在平行目标2中,在相同任务上学习的大鼠将具有 BLA在线或离线,同时记录ACC中的钙痕量。这些方法将使我们能够研究 OFC和ACC中的不确定性表示不同地依赖于BLA输入。我的核心假设是 OFC和ACC使用BLA提供的信息的方式不同:OFC从BLA接收信息, 检测第一次逆转并设置未来调整,而ACC使用BLA的信息来近似 概率随时间的变化。

项目成果

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Juan Luis Romero Sosa其他文献

Frontocortical Circuit Modulation of Stimulus- and Action-Based Learning Using a Combination of Electrophysiological, Chemogenetic, and Behavioral Tracking Approaches
  • DOI:
    10.1016/j.biopsych.2022.02.066
  • 发表时间:
    2022-05-01
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  • 作者:
    Alicia Izquierdo;Tony Ye;Andrew Howe;Claudia Aguirre;Juan Luis Romero Sosa
  • 通讯作者:
    Juan Luis Romero Sosa

Juan Luis Romero Sosa的其他文献

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