RFA-PS-23-001 - Project PrOVIDE: PrEP Optimization Via Implementation, Dissemination, and Evaluation

RFA-PS-23-001 - 项目提供：通过实施、传播和评估优化 PrEP

• 批准号: 10820208
• 负责人: Amy Kristen Johnson
• 金额: $ 200万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2027-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10820208
• 关键词: RFA; PS; 23; 001; Project

PROJECT SUMMARY Significant disparities in pre-exposure prophylaxis (PrEP) for HIV prevention exist in the U.S. with cisgender women making up a disproportionately low percentage of PrEP users compared to men. 60% of new HIV diagnoses among women are among Black cisgender women. Challenges exist at each step of the PrEP care continuum, including difficulty identifying Black cisgender women at highest risk for HIV who are most likely to benefit from PrEP, women’s own low self-perception of HIV risk, low levels of PrEP knowledge, and barriers to PrEP initiation and persistence. While there has been growing knowledge of interventions to increase PrEP use among men who have sex with men and transgender women, much less is known about successful implementation strategies to increase uptake and support PrEP persistence among Black cisgender women. Our team’s preliminary mixed methods work identified PrEP implementation strategies for Black cisgender women consisting of: routine PrEP education for patients, standardized provider training, electronic medical record tools, PrEP navigation, clinical champions, and mHealth tools. We propose to adapt, implement, and evaluate the impact of these strategies to improve PrEP care continuum outcomes for Black cisgender women across six counties in the U.S. using implementation science research methods. PrEP implementation planning will guide strategy selection and identification of new implementation strategies. Our team proposes the following aims: AIM 1: Identify, select, and adapt implementation strategies for engaging Black women in the PrEP care continuum in six clinic settings in EHE priority areas (midwest, north, south). AIM 2: Determine the effectiveness of PrOVIDE implementation strategies on PrEP uptake among Black cisgender women across six clinic sites via a hybrid type II study design. AIM 3: Assess and document implementation outcomes and report on key barriers and facilitators related to successful implementation of the implementation strategies using the RE-AIM framework.

项目摘要 在美国，顺性别人群在预防艾滋病毒的暴露前预防（PrEP）方面存在显著差异。 与男性相比，女性在PrEP使用者中所占比例不成比例地低。60%的新艾滋病毒 女性中的诊断是黑人cisgender妇女。PrEP护理的每一步都存在挑战 连续性，包括难以确定最有可能感染艾滋病毒的黑人顺性别妇女， 从PrEP中受益，妇女自己对艾滋病毒风险的自我认知较低，PrEP知识水平低，以及 PrEP启动和持续性。虽然人们越来越了解增加PrEP的干预措施， 在与男性发生性关系的男性和变性女性中使用，对成功的了解要少得多。 实施战略，以增加黑人cisgender妇女的吸收和支持PrEP的持久性。 我们团队的初步混合方法工作确定了黑人顺性别者的PrEP实施策略 女性包括：患者的常规PrEP教育，标准化提供者培训，电子医疗 记录工具，PrEP导航，临床冠军和移动健康工具。我们建议调整、实施和 评估这些策略的影响，以改善黑人cisgender妇女的PrEP护理连续结果 在美国的六个县使用实施科学研究方法。PrEP实施规划 将指导战略选择和确定新的执行战略。我们的团队提出以下建议 目的：目的1：确定，选择和调整实施战略，使黑人妇女参与PrEP护理 在EHE优先地区（中西部、北部、南部）的六个诊所环境中进行连续性研究。目标2：确定有效性 在六个诊所地点的黑人cisgender妇女中， 混合II型研究设计。目标3：评估和记录执行成果，并报告主要障碍 与使用RE-AIM成功实施实施战略相关的协调员 框架.