Conceptual Models of Childhood Adversity: Multivariate and Neural Approaches

童年逆境的概念模型：多元和神经方法

• 批准号: 10827162
• 负责人: Ann-Marie Barrett
• 金额: $ 4.7万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-16 至 2025-09-15
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10827162
• 关键词: Adolescence; Adolescent; Adolescent Development; Adverse event; Age; Area; Behavior; Biology; Brain; Buffers; Child; Childhood; Chronic stress; Clinical; Communication; Computational Technique; Consultations; Data; Data Set; Development; Dimensions; Dose; Female Adolescents; Goals; Health; Individual; Intervention; Knowledge; Life Experience; Link; Longevity; Longitudinal Studies; Measurement; Measures; Mediating; Mediator; Mental Health; Mental disorders; Mentors; Mentorship; Methodology; Methods; Modeling; Neurobiology; Neurosciences; Oregon; Outcome; Pathway interactions; Pattern; Persons; Process; Psychopathology; Reporting; Reproducibility; Research Personnel; Risk; Role; Sampling; Science; Standardization; Stress; Structure; Sum; Symptoms; Techniques; Thinness; Time; Training; Training Support; Undifferentiated; United States; Universities; adolescent brain development; adverse childhood events; age related; biological development; brain based; brain health; career; childhood adversity; deprivation; early life adversity; experience; flexibility; longitudinal analysis; neural; neurodevelopment; neuroimaging; neuromechanism; neurophysiology; resilience factor; response; translational applications; translational neuroscience

PROJECT SUMMARY Childhood adverse experiences confer risk for a multitude of negative long-term health outcomes, but the processes through which these experiences are neurobiologically embedded and possibly buffered by positive experiences are still unclear. Though adversity is regularly associated with differences in brain structure, many studies yield conflicting evidence. These may be resolved through methodological and conceptual advancements that consider the discrepancies in adversity measurement, age-related expressions of neural effects, and possible competing effects of positive childhood experiences. Adolescence, a period of dynamic neural change when many first experience mental health problems, is a promising time to evaluate the effects of childhood adversity on brain development and mental health. This project will employ cutting edge computational techniques to identify the relative advantages of two conceptual models of adversity – the cumulative risk model and dimensional model of psychopathology – as they relate to changes in brain structure and mental health throughout adolescence. To achieve these objectives, this project draws from up to six waves of data from a longitudinal sample of 174 adolescent girls (initial ages 10-13, ~18 months between waves). The specific aims are: 1) evaluate the fit of cumulative and dimensional models of adversity with longitudinal trajectories of mental health symptoms; 2) evaluate the fit of cumulative and dimensional models of adversity with structural brain development and determine the viability of brain-as-a-mediator model; and 3) identify the effect of positive life experiences on adversity-brain-health relationships. Completion of these aims will sharpen scientific understanding of these conceptual models and provide targets for translational application. To facilitate a career as a clinical and developmental neuroscientist, this project has five training goals: develop expertise in 1) operationalizing childhood experiences to predict meaningful outcomes; 2) employing longitudinal univariate and multivariate techniques; 3) adolescent structural brain development; 4) science communication; and 5) professional development. This training will occur within the state-of-the-art Center for Translational Neuroscience at the University of Oregon. Dr. Jennifer Pfeifer will be the primary mentor due to her extensive knowledge of adolescent development and neuroimaging. Dr. Philip Fisher, an expert in the effects of early adversity, will provide expertise on the conceptual models of adversity. Dr. Robert Chavez will provide mentorship related to his considerable experience in multivariate modeling. Dr. Kathryn Mills will support training in adolescent brain development and reproducible neuroscience practices as a consultant with considerable expertise in those areas. Dr. Jena Doom, who has expertise in protective mechanisms against childhood stress, will serve as a consultant on the operationalization of benevolent childhood experiences. Given his expertise in longitudinal modeling in developmental neuroimaging, Dr. Kevin King will provide consultation for longitudinal modeling considerations.

项目概要 童年不良经历会带来多种负面长期健康结果的风险，但 这些经历在神经生物学上是嵌入的，并可能被积极的缓冲所缓冲。 经验仍不清楚。尽管逆境通常与大脑结构的差异有关，但许多人 研究得出了相互矛盾的证据。这些可以通过方法论和概念来解决 考虑到逆境测量的差异、与年龄相关的神经表达的差异 影响，以及积极的童年经历可能产生的竞争影响。青春期，一个充满活力的时期 当许多人第一次经历心理健康问题时，神经发生变化，是评估其影响的一个有希望的时机 童年逆境对大脑发育和心理健康的影响。该项目将采用尖端技术 计算技术来确定两种逆境概念模型的相对优势—— 精神病理学的累积风险模型和维度模型——因为它们与大脑结构的变化有关 和整个青春期的心理健康。为了实现这些目标，该项目吸引了多达六名 来自 174 名青春期女孩（最初年龄 10-13 岁，中间约 18 个月）的纵向样本的数据波 波）。具体目标是：1）评估逆境的累积模型和维度模型与 心理健康症状的纵向轨迹； 2）评估累积模型和维度模型的拟合度 逆境与大脑结构发育的关系，并确定大脑作为中介模型的可行性；和 3) 确定积极的生活经历对逆境-大脑-健康关系的影响。完成这些目标 将加深对这些概念模型的科学理解，并为转化提供目标 应用。为了促进临床和发育神经科学家的职业生涯，该项目有五项培训 目标：发展以下方面的专业知识：1）运用童年经历来预测有意义的结果； 2） 采用纵向单变量和多变量技术； 3）青少年大脑结构发育； 4） 科学传播； 5) 专业发展。该培训将在最先进的环境下进行 俄勒冈大学转化神经科学中心。 Jennifer Pfeifer 博士将担任主要负责人 由于她对青少年发展和神经影像学的广泛了解，她成为了导师。菲利普·费舍尔博士 早期逆境影响方面的专家，将提供有关逆境概念模型的专业知识。罗伯特博士 查韦斯将提供与他在多元建模方面丰富经验相关的指导。凯瑟琳博士 米尔斯将支持青少年大脑发育和可重复的神经科学实践培训，作为 在这些领域拥有丰富专业知识的顾问。 Jena Doom 博士，拥有防护方面的专业知识 应对儿童压力的机制，将作为仁慈项目运作的顾问 童年经历。鉴于他在发育神经影像纵向建模方面的专业知识，Kevin 博士 King 将提供纵向建模考虑因素的咨询。