Neurophysiological Social Reward Processing, Birth Trauma, and Depression Symptoms in the Peripartum Period

神经生理学社会奖赏处理、分娩创伤和围产期抑郁症状

• 批准号: 10824066
• 负责人: Emilia Francina Cardenas
• 金额: $ 4.77万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-08 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10824066
• 关键词: Accounting; Automobile Driving; Behavior; Birth; Birth trauma; Brain; Brain region; Childbirth; Code; Cognitive; Cues; Data; Depressed mood; Development; Diagnosis; Dimensions; Distress; Electroencephalography; Emergency Situation; Emotional; Environmental Risk Factor; Etiology; Event-Related Potentials; Exhibits; Exposure to; Feedback; Fellowship; Frequencies; Funding; Future; Impairment; Infant; Intervention; Interview; Labor Complications; Longitudinal Studies; Maintenance; Measures; Medial; Medical; Mental Depression; Methods; Modeling; Mothers; Outcome; Participant; Pathway interactions; Perinatal; Postpartum Depression; Postpartum Period; Prefrontal Cortex; Pregnancy; Process; Protocols documentation; Reporting; Research; Research Personnel; Rewards; Risk; Risk Factors; Role; Severities; Shapes; Social Impacts; Stimulus; Stress; Stressful Event; Testing; Time; Training; Trauma; Ventral Striatum; Woman; adverse outcome; antepartum depression; career; caregiving; contextual factors; depression model; depressive symptoms; expectation; experience; functional disability; innovation; maternal outcome; neural; neurophysiology; novel; offspring; peripartum depression; pre-doctoral; prospective; response; reward processing; skills; social; social attachment; suicidal risk; trauma symptom

PROJECT SUMMARY/ABSTRACT Peripartum depression (i.e., depression during pregnancy and following childbirth; PPD) is prevalent and debilitating for women. PPD is associated with significant negative outcomes, including functional impairment and suicidality risk in mothers as well as cognitive, developmental, emotional, and social impacts on infants. Another common factor impacting women during the peripartum period is birth trauma. Nearly half of women giving birth endorse birth trauma, including labor complications, emergency interventions that violate expectations, or needs for intensive medical treatment. Depression during pregnancy is a known risk factor for birth trauma. Further, birth trauma is associated with a range of adverse outcomes for mothers and offspring similar to the effects of PPD. Many women endorsing birth trauma do not develop PPD, raising questions about vulnerabilities for depression that may contribute to PPD in interaction with birth trauma. Vulnerability- stress models of depression posit depression is the result of interactions between underlying vulnerabilities and stress. Growing evidence supports the use of neuroscientific methods to identify depression vulnerabilities across development, such as reduced neural reward responsiveness. Further, stress moderates effect of reward processing on subsequent depression. Reward processing may interact with birth trauma on PPD symptoms. As part of a larger project, this project measures neural social reward responsiveness using a novel and ecologically valid paradigm, birth trauma objectively coded based on contextual factors, and depressive symptoms assessed in 120 mothers. Depression symptoms and diagnoses are collected across pregnancy and postpartum. During an assessment at 8 weeks postpartum, participants complete a novel social inventive delay task while electroencephalogram is recorded in response to reward (i.e., green arrow leading to a photo of participant’s infant) and neutral feedback (i.e., red arrow leading to a photo of rocks). Event-related potential (e.g., the reward positivity, a time-domain measure of reward responsiveness) and time-frequency data (i.e., delta activity, a frequency-domain marker of sensitivity to rewards) are used to measure neurophysiological response to social reward. Further, participants complete the Birth Experience Interview to capture dimensions of birth trauma (i.e., overall severity, violations of expectations, and loss of control). The project examines the effects of low social reward responsiveness (Aim 1) and birth trauma (Aim 2) on PPD symptoms, accounting for depressive symptoms during pregnancy. Further, the project tests birth trauma as a moderator of associations between social reward responsiveness and postpartum depressive symptoms, accounting for depressive symptoms during pregnancy (Aim 3). This project brings together experts in respective fields and allow for advanced training on the role of stress and trauma in PPD, advanced EEG methods, and advanced quantitative methods. The project and training provide opportunities to develop necessary skills for an independent career as a researcher identifying processes and environmental factors driving PPD risk.

项目概要/摘要 围产期抑郁症（即怀孕期间和分娩后的抑郁症；PPD）很普遍，并且 对女性来说是一种衰弱的表现。 PPD 与显着的负面结果相关，包括功能障碍 母亲的自杀风险以及对婴儿的认知、发育、情感和社会影响。 影响围产期妇女的另一个常见因素是产伤。近一半的女性 分娩认可产伤，包括分娩并发症、违反规定的紧急干预措施 对强化医疗的期望或需求。怀孕期间的抑郁症是已知的危险因素 产伤。此外，产伤与母亲和后代的一系列不良后果有关 与PPD的作用相似。许多支持产伤的女性并未患上产后抑郁症，这引发了疑问 关于抑郁症的脆弱性可能会导致产后抑郁症与产伤的相互作用。漏洞- 抑郁症的压力模型假设抑郁症是潜在脆弱性之间相互作用的结果 和压力。越来越多的证据支持使用神经科学方法来识别抑郁症的脆弱性 跨越发展，例如神经奖励反应能力降低。此外，压力会减弱 对随后抑郁症的奖励处理。奖励处理可能与 PPD 上的产伤相互作用 症状。作为一个更大项目的一部分，该项目使用一种新颖的方法来测量神经社会奖励反应性 和生态有效的范式、基于背景因素客观编码的产伤和抑郁 对 120 名母亲的症状进行了评估。整个怀孕期间收集抑郁症状和诊断 和产后。在产后 8 周的评估中，参与者完成了一项新颖的社会发明 延迟任务，同时记录脑电图以响应奖励（即通向照片的绿色箭头） 参与者婴儿的照片）和中性反馈（即红色箭头指向岩石照片）。事件相关电位 （例如，奖励积极性，奖励响应性的时域度量）和时频数据（即， delta 活动（对奖励敏感度的频域标记）用于测量神经生理学 对社会奖励的反应。此外，参与者完成出生经历访谈以捕捉维度 产伤（即总体严重程度、违反预期和失控）。该项目审查了 低社会奖赏反应性（目标 1）和产伤（目标 2）对 PPD 症状的影响，会计 用于怀孕期间的抑郁症状。此外，该项目测试了产伤作为调节因素 社会奖励反应与产后抑郁症状之间的关联，解释 怀孕期间的抑郁症状（目标 3）。该项目汇集了各个领域的专家 允许进行有关压力和创伤在 PPD 中的作用的高级培训、高级脑电图方法和高级 定量方法。该项目和培训提供了培养必要技能的机会 作为一名独立的研究人员，识别驱动 PPD 风险的过程和环境因素。