Neurophysiological Social Reward Processing, Birth Trauma, and Depression Symptoms in the Peripartum Period

神经生理学社会奖赏处理、分娩创伤和围产期抑郁症状

• 批准号: 10824066
• 负责人: Emilia Francina Cardenas
• 金额: $ 4.77万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-08 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10824066
• 关键词: Accounting; Automobile Driving; Behavior; Birth; Birth trauma; Brain; Brain region; Childbirth; Code; Cognitive; Cues; Data; Depressed mood; Development; Diagnosis; Dimensions; Distress; Electroencephalography; Emergency Situation; Emotional; Environmental Risk Factor; Etiology; Event-Related Potentials; Exhibits; Exposure to; Feedback; Fellowship; Frequencies; Funding; Future; Impairment; Infant; Intervention; Interview; Labor Complications; Longitudinal Studies; Maintenance; Measures; Medial; Medical; Mental Depression; Methods; Modeling; Mothers; Outcome; Participant; Pathway interactions; Perinatal; Postpartum Depression; Postpartum Period; Prefrontal Cortex; Pregnancy; Process; Protocols documentation; Reporting; Research; Research Personnel; Rewards; Risk; Risk Factors; Role; Severities; Shapes; Social Impacts; Stimulus; Stress; Stressful Event; Testing; Time; Training; Trauma; Ventral Striatum; Woman; adverse outcome; antepartum depression; career; caregiving; contextual factors; depression model; depressive symptoms; expectation; experience; functional disability; innovation; maternal outcome; neural; neurophysiology; novel; offspring; peripartum depression; pre-doctoral; prospective; response; reward processing; skills; social; social attachment; suicidal risk; trauma symptom

PROJECT SUMMARY/ABSTRACT Peripartum depression (i.e., depression during pregnancy and following childbirth; PPD) is prevalent and debilitating for women. PPD is associated with significant negative outcomes, including functional impairment and suicidality risk in mothers as well as cognitive, developmental, emotional, and social impacts on infants. Another common factor impacting women during the peripartum period is birth trauma. Nearly half of women giving birth endorse birth trauma, including labor complications, emergency interventions that violate expectations, or needs for intensive medical treatment. Depression during pregnancy is a known risk factor for birth trauma. Further, birth trauma is associated with a range of adverse outcomes for mothers and offspring similar to the effects of PPD. Many women endorsing birth trauma do not develop PPD, raising questions about vulnerabilities for depression that may contribute to PPD in interaction with birth trauma. Vulnerability- stress models of depression posit depression is the result of interactions between underlying vulnerabilities and stress. Growing evidence supports the use of neuroscientific methods to identify depression vulnerabilities across development, such as reduced neural reward responsiveness. Further, stress moderates effect of reward processing on subsequent depression. Reward processing may interact with birth trauma on PPD symptoms. As part of a larger project, this project measures neural social reward responsiveness using a novel and ecologically valid paradigm, birth trauma objectively coded based on contextual factors, and depressive symptoms assessed in 120 mothers. Depression symptoms and diagnoses are collected across pregnancy and postpartum. During an assessment at 8 weeks postpartum, participants complete a novel social inventive delay task while electroencephalogram is recorded in response to reward (i.e., green arrow leading to a photo of participant’s infant) and neutral feedback (i.e., red arrow leading to a photo of rocks). Event-related potential (e.g., the reward positivity, a time-domain measure of reward responsiveness) and time-frequency data (i.e., delta activity, a frequency-domain marker of sensitivity to rewards) are used to measure neurophysiological response to social reward. Further, participants complete the Birth Experience Interview to capture dimensions of birth trauma (i.e., overall severity, violations of expectations, and loss of control). The project examines the effects of low social reward responsiveness (Aim 1) and birth trauma (Aim 2) on PPD symptoms, accounting for depressive symptoms during pregnancy. Further, the project tests birth trauma as a moderator of associations between social reward responsiveness and postpartum depressive symptoms, accounting for depressive symptoms during pregnancy (Aim 3). This project brings together experts in respective fields and allow for advanced training on the role of stress and trauma in PPD, advanced EEG methods, and advanced quantitative methods. The project and training provide opportunities to develop necessary skills for an independent career as a researcher identifying processes and environmental factors driving PPD risk.

项目总结/摘要 围产期抑郁症（即，抑郁症在怀孕期间和分娩后; PPD）是普遍的， 对女性来说是一种折磨。PPD与显著的不良结局相关，包括功能障碍 母亲的自杀风险以及对婴儿的认知、发育、情感和社会影响。 另一个影响妇女围产期的常见因素是分娩创伤。近一半的女性 分娩认可分娩创伤，包括分娩并发症，违反 期望，或需要强化医疗。怀孕期间的抑郁症是一个已知的危险因素， 产伤此外，产伤与母亲和后代的一系列不良后果有关 类似于PPD的效果。许多赞同产伤的妇女并没有患上PPD，这引起了人们的质疑。 抑郁症的脆弱性可能导致产后抑郁症与产伤的相互作用。脆弱性- 抑郁症的压力模型抑郁症是潜在脆弱性之间相互作用的结果 和压力越来越多的证据支持使用神经科学方法来识别抑郁症的脆弱性 在整个发展过程中，例如减少神经奖励反应。此外，压力缓和了 奖励处理对后续抑郁症的影响奖励处理可能与PPD上的产伤相互作用 症状作为一个更大的项目的一部分，该项目使用一种新颖的方法测量神经社会奖励反应。 和生态有效的范式，产伤客观编码的基础上的背景因素，和抑郁症 在120名母亲中评估症状。抑郁症状和诊断是在怀孕期间收集的 和产后。在产后8周的评估中，参与者完成了一项新的社会发明， 延迟任务，同时记录脑电波以响应奖励（即，指向照片的绿色箭头 参与者的婴儿）和中性反馈（即，红色箭头指向岩石照片）。事件相关电位 (e.g.,奖励积极性，奖励响应性的时域测量）和时间-频率数据（即， δ活动，对奖赏敏感性的频域标记）被用于测量神经生理学 对社会奖励的反应。此外，参与者完成出生体验访谈，以获取维度 出生创伤（即，总体严重性、违反预期和失去控制）。该项目审查了 低社会奖励反应性（目标1）和产伤（目标2）对PPD症状的影响，会计 治疗怀孕期间的抑郁症状此外，该项目还测试了出生创伤作为 社会奖励反应性和产后抑郁症状之间的关联，占 怀孕期间的抑郁症状（目标3）。该项目汇集了各个领域的专家， 允许对压力和创伤在PPD中的作用进行高级培训，先进的EEG方法，以及先进的 定量方法该项目和培训提供了机会，以发展必要的技能， 作为一个独立的职业生涯，研究人员确定的过程和环境因素驱动PPD风险。