Clinical Center for NICHD/Neonatal Research Network

NICHD 临床中心/新生儿研究网络

• 批准号: 10841989
• 负责人: Sara Bonamo DeMauro
• 金额: $ 33.55万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2030-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10841989
• 关键词: 2 year old; 21 year old; 3 year old; 4 year old; Age; Auditory; Auditory area; Birth; Birth Weight; Brain; Brain imaging; Child; Clinical; Data; Data Collection; Development; Education; Enrollment; Faculty; Frequencies; Funding; Generations; Gestational Age; Goals; Hospitalization; Image; Individual; Infant; Institution; Intervention; Language; Language Delays; Language Development; Language Disorders; Language Therapy; Magnetic Resonance Imaging; Magnetoencephalography; Measures; Medical; Medical center; Meta-Analysis; Methods; Modeling; Multicenter Neonatal Research Network; National Institute of Child Health and Human Development; Nature; Neonatal; Neurophysiology - biologic function; Nursery Schools; Outcome; Outcome Measure; Parents; Participant; Pediatric Hospitals; Pennsylvania; Perinatal; Phase; Philadelphia; Premature Infant; Procedures; Process; Qualifying; Race; Recording of previous events; Research; Research Personnel; Resources; Rest; Risk; Risk Factors; Sampling; Shapes; Site; Specificity; Speech Therapy; Speed; Structure; System; Toddler; Universities; Vocabulary Test; clinical center; cognitive ability; cohort; developmental disease; experience; extreme prematurity; gray matter; high risk infant; improved; indexing; interest; language disorder diagnosis; language impairment; language outcome; neonatal morbidity; neural; neural circuit; neural network; neuroimaging; neuromechanism; research clinical testing; response; sex; skills; sociodemographic factors; sociodemographic predictors; sociodemographics; socioeconomics; sound; success; white matter

ABSTRACT Children born extremely preterm (EP) (<27 weeks gestational age (GA)) are atincreased risk of having a languagedisorder or late language emergence 1-5. The proposed study seeks to identify the neural circuit mechanisms and socio-demographic factors that contribute to variable language outcome in extremely preterm (EP) children at 3 years corrected age (CA). This supplemental funding application is submitted as one of a pair of applications from the University of Pennsylvania/Children's Hospital of Philadelphia (Penn/CHOP) and Cincinnati Children's Hospital Medical Center (CCHMC). The PIs at Penn/CHOP and CCHMC, Drs. DeMauro and Merhar, are PIs of the NICHD Neonatal Research Network (NRN) Clinical Centers at their respective institutions, which serve as the parent studies for the current proposal. The NRN follows all infants born EP and other high-risk infants from birth to 22-26 months CA, collecting developmental outcomes and therapies received, and perinatal, medical, and socio-demographic data. For the proposed project, they engaged highly motivated and qualified junior faculty with expertise in neural imaging and language development from both sites (Dr. Chen from CHOP; Dr. Barnes-Davis from CCHMC). The proposed study employs a suite of magnetoencephalography (MEG) neural measures and language assessments to evaluate if task-based neural measures are differentially associated with variable receptive and expressive language outcome in EP children at 3 years CA in comparison to term-born controls (TC) children. Using tasks developed by Dr. Chen and Dr. Barnes-Davis, neural measures of interest are: (1) auditory encoding processes = M50 latency 6-15, (2) functional connectivity during receptive (story listening) and expressive (verb generation) language processes = weighted phase lag index (wPLI) 16, 17, and (3) resting-state (RS) peak alpha frequency (PAF), a brain rhythm associated with connectivity between neural networks 18-20. Leveraging both the existing CHOP NRN cohort with neonatal and completed developmental data at age 2 years and a CHOP longitudinal TC cohort who have completed longitudinal neuroimaging and developmental data from birth to age 2, MEG and language measures will be obtained in 60 EP and 60 TC children at 3-3.5 years CA. The same MEG task data and language outcome measures will be obtained in the EP and TC cohorts at CCHMC, for a total enrollment of 100 EP and 100 TC participants across two sites, enhancing the power and generalizability of the proposed study. Sharing of methods and data across the two centers permits rapid and efficient data collection of a socioeconomically diverse EP sample. It is anticipated that the elucidation of neural risk factors will provide increased specificity to the nature of variable language outcome in young children born EP. Study findings are also expected to lead to timely and more tailored clinical interventions that shape the maturation of language neural networks and specifically meet the goal of the TALK NOSI, “to engage in activities that will help to elucidate the unique trajectories and needs of late talking children.”

摘要 极早产（EP）（胎龄<27周（GA））的儿童发生早产的风险增加。 语言障碍或语言出现晚1-5。这项拟议中的研究旨在确定神经回路 机制和社会人口因素，有助于变量的语言结果，在极 3岁校正年龄（CA）的早产儿（EP）。此补充资金申请是作为 宾夕法尼亚大学/费城儿童医院的两份申请之一 (Penn/CHOP）和辛辛那提儿童医院医疗中心（CCHMC）。Penn/CHOP的PI和 CCHMC，DeMauro和Merhar博士是NICHD新生儿研究网络（NRN）临床中心的PI 在其各自的机构，作为本提案的母体研究。NRN遵循所有 从出生到22-26个月CA的EP婴儿和其他高危婴儿，收集发育结局 和接受的治疗，以及围产期、医疗和社会人口统计数据。对于拟议的项目，他们 聘请了在神经成像和语言方面具有专业知识的积极性和合格的初级教师 来自两个研究中心的Dr. Chen和Dr. Barnes-Davis（来自CCHMC）。拟定研究 采用一套脑磁图（MEG）的神经措施和语言评估，以评估 如果基于任务的神经测量与可变的接受性和表达性语言有不同的关联， 与足月出生对照（TC）儿童相比，EP儿童3年CA的结局。使用任务 由Chen博士和Barnes-Davis博士开发，感兴趣的神经测量是：（1）听觉编码 过程= M50潜伏期6-15，（2）在接受（听故事）和表达（动词）过程中的功能连接 代）语言过程=加权相位滞后指数（wPLI）16、17，以及（3）静息状态（RS）峰值α 频率（PAF），与神经网络18-20之间的连接相关的脑节律。利用两者 现有的CHOP NRN队列，具有新生儿和2岁时完成的发育数据，以及CHOP 已完成从出生到出生的纵向神经影像学和发育数据的纵向TC队列 对60名EP和60名TC儿童在3-3.5岁CA时进行2岁、MEG和语言测量。的 将在CCHMC的EP和TC队列中获得相同的MEG任务数据和语言结局指标， 两个研究中心共招募100名EP和100名TC参与者，增强了 拟议研究的普遍性。通过在两个中心之间共享方法和数据， 有效收集社会经济多样性EP样本的数据。预计， 神经危险因素将为年轻人的可变语言结果的性质提供更高的特异性， 孩子出生EP。研究结果还有望导致及时和更有针对性的临床干预措施， 塑造语言神经网络的成熟，特别是满足TALK NOSI的目标，“ 参与有助于阐明晚说话儿童独特轨迹和需求的活动。”