Clinical Center for NICHD/Neonatal Research Network

项目总结 尤尼斯·肯尼迪·施莱弗NICHD合作多中心新生儿研究网络(NRN)致力于 为照顾患病和早产儿提供强有力的科学依据，促进健康 结果。自2011年以来，宾夕法尼亚大学佩雷尔曼医学院(宾夕法尼亚大学)和儿童 费城医院(CHOP)临床中心一直在各个方面做出重大贡献 NRN研究。我们的临床中心包括三个大型三级新生儿重症监护病房 围产期中心、一家儿童医院的一个大型四级病房和三个后续诊所，所有这些都是 统一在宾夕法尼亚大学/CHOP新生儿学部的领导下。我们是领先的NRN临床中心 用于招聘、留住和学习跟踪。我们在目前的15家临床中心中排名第三 婴儿被招募到目前正在进行的五项随机试验中。宾夕法尼亚大学/CHOP大学2年随访率为 持续高于NRN的平均随访率。自从我们加入NRN以来，我们一直在进行后续 在宾夕法尼亚大学/CHOP研究参与者中，98.5%(391人中的385人)18-26个月的就诊时间纠正了年龄 临床试验。我们的调查人员和协调员在NRN内部发挥着重要的领导作用，在 多个小组委员会，并通过NRN开放网络机制促进新中心的启动。 我们的首席调查员领导了两项关于NRN试验和Penn/CHOP的大型学龄期后续研究 自我们上次竞争续签以来，调查人员已经以第一作者或高级作者的身份发表了27篇NRN手稿。 我们还通过我们团队在创新流行病学技术方面的专业知识做出了独特的贡献 和健康差距。我们已作好充分准备，继续积极参与北大西洋公约组织，贡献我们的 团队在临床研究方法方面的特殊优势，作为合作伙伴和富有成效的合作伙伴在 正在进行的研究，并推出创新的新议定书，以推进NICHD NRN的科学任务 在下一个颁奖周期。

PROJECT SUMMARY The Eunice Kennedy Shriver NICHD cooperative multicenter Neonatal Research Network (NRN) is committed to providing a strong scientific evidence base for the care of sick and preterm newborns to promote healthy outcomes. Since 2011, the University of Pennsylvania Perelman School of Medicine (Penn) and Children’s Hospital of Philadelphia (CHOP) Clinical Center has been making significant contributions to all aspects of NRN research. Our Clinical Center includes three large level three neonatal intensive care units in academic perinatal centers, one large level four unit in a children’s hospital, and three follow-up clinics, all of which are unified under the leadership of the Penn/CHOP Division of Neonatology. We are a leading NRN Clinical Center for recruitment, retention, and study follow-up. We rank #3 among the 15 current Clinical Centers for number of infants recruited into the five currently ongoing randomized trials. Penn/CHOP 2-year follow-up rates are consistently higher than NRN average follow-up rates. Since we joined the NRN, we have conducted follow-up visits at 18-26 months corrected age in 98.5% (385 of 391) of Penn/CHOP study participants enrolled in 9 clinical trials. Our investigators and coordinators provide important leadership within the NRN, serving on multiple subcommittees and facilitating startup of new centers through the NRN Open Network mechanism. Our Principal Investigator leads two large school-age follow-up studies of NRN trials and Penn/CHOP investigators have published 27 NRN manuscripts as first or senior author since our last competitive renewal. We also provide unique contributions through our team’s expertise in innovative epidemiological techniques and health disparities. We are fully prepared to continue our robust participation in the NRN by contributing our team’s special strengths in clinical research methodology, collaborating as collegial and productive partners in ongoing studies, and introducing innovative new protocols to advance the scientific mission of the NICHD NRN in the next award cycle.