权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Administrative Diversity Supplement for Ta-Tyonna Buck.

Ta-Tyonna Buck 的行政多元化补充。

基本信息

批准号：
10841785
负责人：
Lakiesha Nicole Williams
金额：
$ 7.66万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2027-07-31
项目状态：
未结题

项目摘要

Project Summary: Cranial dura mater is disrupted during invasive brain surgeries, resulting in major post-surgical complications that may be fatal if left untreated. Commercial dura grafts perform sub-optimally, creating a critical need for a dura graft substitute that maintains structural integrity and reintegrates with minimal inflammation and post-surgical complications. The parent grant will pursue specific aims to evaluate the effectiveness of dura graft substitutes for dura graft replacement. Here we propose supplemental aims to investigate the role of astrocytes in healing following dura graft reintegration. The experiments and goals of the supplemental project will be incorporated into the parent grant’s methods to advance our understanding of the necessary qualities of dura graft substitutes for effective reintegration. The overall goal is for Ms. Ta-Tyonna Buck to investigate the role of astrocytes and the contributions they have to neural healing. In Supplemental Aim 1, Ta-Tyonna will utilize an in vitro model to assess the molecular mechanisms of astrocytes on the dura graft substitutes via a 3D co-culture system. In Supplemental Aim 2, she will assess the role of astrocytes in an in vivo model to measure the impact and reactivity of astrocytes following dura graft reintegration. Ta-Tyonna will gain an extensive skillset in biomedical imaging and microscopy, all of which are needed to progress in the proposed goals. Ta-Tyonna will meet weekly with Dr. Williams and the Williams lab for mentoring, research updates, feedback, and reviewing updated literature. Additionally, Ta-Tyonna will meet monthly with the parent grant investigator team for mentoring and updates on all studies. She will participate in workshops for research and writing success at UF, attend national conferences to present her work, and mentor undergraduates conducting research in the Williams Lab. Furthermore, she will attend professional development activities at conferences and research symposia to take advantage of their many networking and learning opportunities. The combined research and learning activities have been strategically outlined to support Ta-Tyonna’s progress throughout her Ph.D. and as she pursues a career in research.

项目摘要：侵入性颅脑手术中硬脑膜被破坏，导致在手术后的重大并发症中，如果不治疗可能是致命的。商用硬脑膜移植物表现不佳，迫切需要一种硬脑膜移植替代品，以保持结构完整，术后炎症最小，愈合良好并发症。家长奖助金将追求具体目标，以评估硬脑膜移植替代硬脑膜移植。在这里，我们提出补充目标以研究星形胶质细胞在硬脑膜移植后愈合中的作用。这些实验补充项目的目标将被纳入父母赠款的方法中，以增进我们对硬脑膜移植替代品有效所需品质的理解重新融入社会。总体目标是Ta-Tyonna Buck女士研究星形胶质细胞和他们对神经康复的贡献。在补充目标1中，Ta-Tyonna将利用体外模型评价星形胶质细胞在硬脑膜移植中的分子机制通过3D共培养系统进行替代。在补充目标2中，她将评估星形胶质细胞在体内模型中测量星形胶质细胞对硬脑膜的影响和反应性移植物再融合。 Ta-Tyonna将在生物医学成像和显微镜方面获得广泛的技能，所有这些都是需要在拟议的目标方面取得进展。Ta-Tyonna将每周与Williams博士会面，并威廉姆斯实验室用于指导、研究更新、反馈和审查更新文学。此外，Ta-Tyonna将每月与家长赠款调查员团队会面，以指导和更新所有研究。她将参加研究和写作的研讨会在密歇根大学取得成功，参加全国性的会议介绍她的工作，并指导本科生在威廉姆斯实验室进行研究。此外，她还将参加职业发展在会议和研究研讨会上的活动，以利用他们的众多关系网和学习机会。综合的研究和学习活动一直是战略规划，以支持Ta-Tyonna在整个博士期间和在她追求的过程中取得的进步从事研究工作。