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Behavioral and neurocognitive mechanisms linking peer victimization to adolescent psychopathology

将同伴受害与青少年精神病理学联系起来的行为和神经认知机制

基本信息

批准号：
10840522
负责人：
Alexandra Mayorca Rodman
金额：
$ 24.9万
依托单位：
NORTHEASTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-13 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10840522
关键词：
Adolescence Adolescent Adult Affect Amygdaloid structure Anterior Anxiety Award Behavior Behavior assessment Behavioral Behavioral Mechanisms Clinical Sciences Cognitive Communication Complex Computer Models Corpus striatum structure Data Detection Development Developmental Process Dimensions Disease Dorsal Early Intervention Ecological momentary assessment Emotional Evaluation Exposure to Functional Magnetic Resonance Imaging Insula of Reil Intervention Laboratories Left Life Link Location Longevity Machine Learning Mediating Mental Depression Modeling Monitor Motivation Neurocognitive Pathway interactions Pattern Phase Phenotype Physical activity Physiological Play Process Psychopathology Recurrence Reporting Research Research Personnel Rewards Risk Risk Factors Role Shapes Social Behavior Suicide Symptoms Techniques Telephone Testing Time Training Victimization Youth behavior influence biological adaptation to stress career computational neuroscience deprivation digital experience experimental study handheld mobile device information processing innovation longitudinal design machine learning method mobile computing negative affect neural neuromechanism novel novel strategies peer peer victimization positive emotional state predictive modeling prevent prospective psychosocial response reward processing skills social social communication social engagement social exclusion social media social neuroscience statistical and machine learning suicidal suicidal behavior tool two-dimensional

项目摘要

PROJECT SUMMARY/ABSTRACT Adolescence is a period of heightened vulnerability for many forms of psychopathology, particularly depression, anxiety, and suicidal behaviors. Disorders that emerge during this time have lasting consequences, including elevated risk of recurrence, and poor psychosocial functioning. This vulnerability comes at a time when peer victimization becomes more common and emotional and physiological responses to peer rejection are elevated, rendering victimization particularly damaging during adolescence. Despite the strong links between peer victimization and internalizing problems during adolescence, the behavioral and neural mechanisms underlying this association remain unclear, limiting our ability to prevent the onset of victimization-related psychopathology in youth. The proposed project will test a novel conceptual model, in which it is proposed that two underlying dimensions of peer victimization, peer threat (e.g., presence of negative social experiences, like rejection) and peer deprivation (e.g., absence of positive social experiences, like ostracism) differentially shape neurocognitive processes and social behaviors that have relevance for psychopathology. Specifically, it is argued that peer threat influences neurocognitive and behavioral processes in ways that enhance threat detection and processing (Aim 1), whereas experiences of peer deprivation may contribute to blunted reward sensitivity and low social motivation (Aim 2). The project will then examine whether neurocognitive and behavioral alterations serve as mechanisms linking peer victimization with internalizing psychopathology (Aim 3). The proposed research will test this conceptual model by using a combination of experimental behavioral and fMRI tasks, as well as an intensive longitudinal design, leveraging advancements in digital phenotyping, computational neuroscience, and predictive modeling approaches. Critically, by implementing advanced statistical machine learning methods for predictive modeling, the proposed research may be able to identify patterns of real-world social behavior that are influenced by victimization and, in turn, predict the emergence of psychopathology. Identifying developmental processes that are disrupted following peer victimization and ultimately lead to psychopathology is a necessary first step in developing targeted intervention approaches. This award will also provide the candidate, who has a strong background in developmental social neuroscience and clinical science, with critical training in the implementation of digital phenotyping, computational modeling, and advanced statistical techniques to promote a successful transition to an independent research career.

项目总结/文摘