New England Regional Coordinating Center for the NINDS Stroke Trials Network

NINDS 卒中试验网络新英格兰地区协调中心

• 批准号: 10846315
• 负责人: ANEESH B SINGHAL
• 金额: $ 10.42万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10846315
• 关键词: Achievement; Adult; Area; Blood Vessels; Boston; Caring; Child; Childhood stroke; Clinical Investigator; Clinical Research; Clinical Trials; Clinical Trials Network; Clinical and Translational Science Awards; Collaborations; Discipline; Emergency Medicine; Enrollment; Funding; General Hospitals; Geography; Health; Hospitals; Infrastructure; International; Investigation; Israel; Leadership; Massachusetts; Medical center; Multicenter Trials; National Institute of Neurological Disorders and Stroke; Neurologic; Neurology; New England; New Hampshire; Patient Care; Pediatric Hospitals; Performance; Phase; Positioning Attribute; Principal Investigator; Records; Rehabilitation therapy; Research; Research Infrastructure; Research Institute; Research Personnel; Resources; Role; Seasons; Site; Stroke; StrokeNet clinical trials; StrokeNet trials; Talents; Translational Research; United States National Institutes of Health; Universities; Vermont; Vision; Woman; clinical translation; innovation; member; metropolitan; neuroimaging; neurosurgery; patient population; pre-clinical; programs; recruit; skills; stroke neurology; stroke rehabilitation; stroke trials; suburb; telestroke

PROJECT SUMMARY/ABSTRACT We propose to continue the StrokeNet New England Regional Coordinating Center (NERCC), an integrated team of hospitals in the Greater Boston Area and suburbs, Western Massachusetts, New Hampshire and Vermont that will serve as a top-enrolling site and vibrant contributor to the NINDS StrokeNet Clinical Trials Network. Our group includes most of the major academic adult and pediatric stroke and rehabilitation hospitals in Massachusetts, New Hampshire and Vermont. Our 30+ hospital New England TeleStroke referral network will extend our potential recruitment and become particularly relevant with the upcoming STEP platform trials. All core hospitals have a proven track record of successful management and performance of clinical trials. In particular, all hospitals have an established research infrastructure that performs ongoing clinical research in stroke neurology with strong collaborations across multiple disciplines. The leadership team composed of Principal investigator Aneesh Singhal, MD, Deputy PI Natalia Rost MD, MPH, Site PIs, Deputy Site PIs, and Co-Investigators bring a diverse and complementary set of skills in managing successful translational clinical research programs, serving as members on trial Steering Committees, and positions of national leadership in their fields. Our team includes seasoned clinical investigators in vascular neurology, emergency medicine, neuroendovascular, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and preclinical basic and translational stroke investigation in both adults and children. Strengths of the NERCC team include 1) close personal and professional ties between multiple investigators and site PIs; 2) a large patient population with geographically diverse hospital settings anchored in a major metropolitan area; 3) talented teams of site investigators with track records of scientific achievement, innovation, and subject recruitment in multicenter trials; 4) robust existing NINDS-funded research and clinical trial management infrastructure at most of the sites; 5) existing clinical research programs, e.g., MGH Neurological Clinical Research Institute, NIH Clinical and Translational Science Award programs serving Boston University and all Harvard hospitals; and 6) leadership roles in the SIREN-NETT, NeuroNEXT, DISCOVERY and MarkVCID trial networks. Overall, the NERCC Team has demonstrated outstanding commitment and performance in the first two StrokeNet cycles, and has the resources, vision, and enthusiasm to continue to develop new translational science and successfully execute the NINDS StrokeNet Phase 1,2 and 3 trials.

项目总结/文摘

项目成果

Legislation Increased Medicare Telestroke Billing, But Underbilling And Erroneous Billing Remain Common.

• DOI: 10.1377/hlthaff.2021.00791
• 发表时间: 2022-03
• 期刊: HEALTH AFFAIRS
• 影响因子: 9.7
• 作者: Wilcock, Andrew D.;Schwamm, Lee H.;Zubizarreta, Jose R.;Zachrison, Kori S.;Uscher-Pines, Lori;Majersik, Jennifer J.;Richard, Jessica, V;Mehrotra, Ateev
• 通讯作者: Mehrotra, Ateev

Insurance-Based Disparities in Stroke Center Access in California: A Network Science Approach.

加州中风中心访问中基于保险的差异：网络科学方法。

• DOI: 10.1161/circoutcomes.122.009868
• 发表时间: 2023
• 期刊: Circulation. Cardiovascular quality and outcomes
• 作者: Zachrison,KoriS;Hsia,ReneeY;Schwamm,LeeH;Yan,Zhiyu;Samuels-Kalow,MargaretE;Reeves,MathewJ;CamargoJr,CarlosA;Onnela,Jukka-Pekka
• 通讯作者: Onnela,Jukka-Pekka

Regional Changes in Patterns of Stroke Presentation During the COVID-19 Pandemic.

• DOI: 10.1161/strokeaha.120.031300
• 发表时间: 2021-04
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Etherton MR;Zachrison KS;Yan Z;Sveikata L;Bretzner M;Estrada J;Viswanathan A;Singhal AB;Schwamm LH
• 通讯作者: Schwamm LH

Antithrombotic Therapy for Stroke Prevention in Patients With Ischemic Stroke With Aspirin Treatment Failure.

• DOI: 10.1161/strokeaha.121.034622
• 发表时间: 2021-12
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Lusk JB;Xu H;Peterson ED;Bhatt DL;Fonarow GC;Smith EE;Matsouaka R;Schwamm LH;Xian Y
• 通讯作者: Xian Y

Temporal Trends in Racial and Ethnic Disparities in Endovascular Therapy in Acute Ischemic Stroke.

• DOI: 10.1161/jaha.121.023212
• 发表时间: 2022-03-15
• 期刊: JOURNAL OF THE AMERICAN HEART ASSOCIATION
• 影响因子: 5.4
• 作者: Sheriff, Faheem;Xu, Haolin;Maud, Alberto;Gupta, Vikas;Vellipuram, Anantha;Fonarow, Gregg C.;Matsouaka, Roland A.;Xian, Ying;Reeves, Mathew;Smith, Eric E.;Saver, Jeffrey;Rodriguez, Gustavo;Cruz-Flores, Salvador;Schwamm, Lee H.
• 通讯作者: Schwamm, Lee H.