Real-World Molecularly Targeted Treatment Registry (MaTTeR): a Pilot Study to Enrich CCDI Data Utilizing Directed Electronic Medical Record (EMR) Extraction
真实世界分子靶向治疗登记处 (MaTTeR):利用定向电子病历 (EMR) 提取丰富 CCDI 数据的试点研究
基本信息
- 批准号:10878384
- 负责人:
- 金额:$ 49.59万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2026-11-30
- 项目状态:未结题
- 来源:
- 关键词:AdolescentAdolescent and Young AdultAdolescent and young adult cancer patientsAdultBrain NeoplasmsCaringCephalicChildChildhoodChildhood Brain NeoplasmClinicalClinical DataClinical OncologyClinical TrialsCombined Modality TherapyCommunitiesCommunity Clinical Oncology ProgramComputerized Medical RecordDNA Sequence AlterationDana-Farber Cancer InstituteDataData CollectionData ElementData SetDatabasesDoseDrug usageEcosystemEnrollmentExclusionFormulationFutureGenesGenomicsGoalsHealth Services AccessibilityIndividualInstitutionInvestigational DrugsLabelMalignant Childhood NeoplasmMalignant NeoplasmsModificationMutationOncologistOncologyOutcomePatient-Focused OutcomesPatientsPediatric OncologyPharmaceutical PreparationsPilot ProjectsPrincipal InvestigatorProtocols documentationPublicationsRefractoryRegistriesRelapseReportingResearchResourcesRoleSolid NeoplasmTestingTimeToxic effectUnited States Food and Drug AdministrationWorkWritingcBioPortalcancer genomicsclinical careclinically relevantcohortdata submissiondata visualizationexperiencefeasibility testingfirst-in-humangenomic datagenomic profileshigh riskleukemiamolecular targeted therapiesnovel therapeuticsoff-label useoncology trialpediatric patientsresponsesearch enginetargeted treatmenttooltreatment and outcometreatment durationtumoryoung adult
项目摘要
Project Summary Abstract
Integration of genomic profiling into the care of pediatric, adolescent and young adult (AYA)
patients with cancer has resulted in the identification of potentially targetable alterations and the
use of molecularly targeted therapies (MTT). Pediatric and AYA cancer patients are increasingly
treated with MTT outside of clinical trials. Systematic data collection and publication of MTT use
outside of clinical trials are lacking such that these real-world experiences are not optimally
contributing to the current understanding of MTT use in pediatric and AYA cancers. This project
will utilize genomic data previously contributed to the Children’s Cancer Data Initiative (CCDI)
as well as additional Dana-Farber Cancer Institute (DFCI) institutional cohorts to identify
patients with targetable genomic alterations. We will then identify patients who received targeted
therapies off of a clinical trial and extract key treatment data, including drug information, dose,
dosing formulation, combination treatment, duration of treatment, best response, time to best
response, duration of response, dose modifications due to toxicity, toxicities, manner of
treatment access (off-label, single patient investigational new drug (IND) protocol). The
systematic clinical data collection of MTT use of the CCDI cohort of patients proposed in this
project will serve as the proof of concept of accessing and enriching CCDI data with highly
valuable data that is otherwise imprisoned within the electronic medical record. This project will
establish the feasibility of creating a scalable registry of real-world targeted therapy experience
that can be expanded to additional CCDI datasets and serve as an important future resource for
the pediatric and AYA cancer community.
项目摘要
将基因组分析整合到儿科、青少年和年轻成人(AYA)的护理中
癌症患者已经导致了潜在的靶向改变的鉴定,
分子靶向治疗(MTT)。儿科和AYA癌症患者越来越多地
在临床试验之外用MTT治疗。MTT使用的系统数据收集和发表
缺乏临床试验之外的信息,因此这些现实世界的经验不是最佳的。
有助于目前理解MTT在儿科和AYA癌症中的应用。这个项目
将利用先前提供给儿童癌症数据倡议(CCDI)的基因组数据
以及丹娜-法伯癌症研究所(DFCI)的其他机构队列,
具有靶向基因组改变的患者。然后我们将确定接受靶向治疗的患者
从临床试验中提取关键的治疗数据,包括药物信息,剂量,
给药制剂、联合治疗、治疗持续时间、最佳缓解、至最佳缓解时间
缓解、缓解持续时间、因毒性导致的剂量调整、毒性、给药方式
治疗访问(标签外,单个患者研究性新药(IND)方案)。的
本研究中提出的CCDI患者队列MTT使用的系统性临床数据收集
该项目将作为访问和丰富CCDI数据的概念证明,
有价值的数据,否则被囚禁在电子医疗记录中。该项目将
确定创建现实世界靶向治疗经验的可扩展注册表的可行性
可以扩展到其他CCDI数据集,并作为未来的重要资源,
儿科和AYA癌症社区。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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LAURIE Hollis GLIMCHER其他文献
LAURIE Hollis GLIMCHER的其他文献
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{{ truncateString('LAURIE Hollis GLIMCHER', 18)}}的其他基金
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Repurposing Bruton's tyrosine kinase (BTK) inhibitors to reverse immunosuppression in high-grade serous ovarian cancer (HGSC)
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10512441 - 财政年份:2022
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8259713 - 财政年份:2011
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Schnurri-3 Inhibitors: specific inducers of adult bone formation
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