Understanding Treatment Tolerability in Older Patients with Cancer

了解老年癌症患者的治疗耐受性

基本信息

  • 批准号:
    10884067
  • 负责人:
  • 金额:
    $ 35万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-07-08 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY The overarching goal of this grant proposal supplement, submitted on behalf of the University of Rochester NCI Community Oncology Research Program (UR NCORP) Research Base and the Cancer and Aging Research Group (CARG), is: to continue to evaluate whether items from the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) are associated with tolerability of treatment for advanced cancer in older patients with age-related conditions (i.e., disability, comorbidity, and geriatric syndromes). The growing population of older patients remains underrepresented in research that sets cancer care standards leading to significant disparities in outcomes. In our preliminary research, we found that: 1) close to 60% of older patients develop grade 3-5 toxicity (as measured by NCI’s CTCAE) within three months of starting a new treatment regimen; items from geriatric assessment (GA) were significantly associated with toxicity; 2) older patients with advanced cancer frequently experience multiple symptoms that interfere with function and quality of life (QoL); and 3) older patients often experience toxicities that lead to early discontinuation of treatment, hospitalizations, and mortality. We have an unprecedented opportunity to continue to leverage an existing multi-site cluster randomized study that has completed enrolling adults aged >70 years with age-related conditions who are starting a new treatment regimen for advanced cancer in the UR NCORP network (URCC 13059/“GAP”) (n=700). In addition to clinician-rated CTCAE, GAP captures PRO measures (PRO-CTCAE, GA, satisfaction) at baseline, 4 weeks, 3 months, and 6 months after the start of the new treatment regimen. Extensive data are collected on clinical tolerability metrics including treatment dose modifications, hospitalizations, and mortality. We will collaborate with the U01 consortium to: 1) develop and compare the trajectories of PRO-CTCAE scores and clinician-rated CTCAE grades 2-5 in older patients with age-related conditions; 2) evaluate associations between PRO- CTCAE scores and clinician-rated CTCAE grades with clinical tolerability metrics; 3) evaluate associations between PRO-CTCAE scores and clinician-rated CTCAE grades with PRO endpoints (e.g., function, QoL, satisfaction); and 4) validate a model that identifies older patients with age-related conditions who are at high risk for poor tolerability from treatment for advanced cancer. Developed with stakeholders, our operational definition of tolerability is novel; it includes both clinical outcomes and PRO endpoints. The team, which includes expertise in clinical trials, biostatistics and data science, PRO measurement, and collaborations with CARG and patient advocates (SCOREBoard led by Canin) is uniquely suited to conduct this research. This research will address a critical gap in knowledge of how patient-reported toxicity informs tolerability of treatment in older patients with advanced cancer and age-related conditions.
项目总结

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Supriya G. Mohile其他文献

898: Fractional Percentage of Tumor Volume Removed Predicts Outcome Following Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma
  • DOI:
    10.1016/s0022-5347(18)31126-1
  • 发表时间:
    2007-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Phillip M. Pierorazio;James M. McKiernan;Tara R. McCann;Supriya G. Mohile;Daniel P. Petrylak;Mitchell C. Benson
  • 通讯作者:
    Mitchell C. Benson
Yoga for the Management of Cancer Treatment-Related Toxicities
  • DOI:
    10.1007/s11912-018-0657-2
  • 发表时间:
    2018-01-01
  • 期刊:
  • 影响因子:
    5.000
  • 作者:
    Po-Ju Lin;Luke J. Peppone;Michelle C. Janelsins;Supriya G. Mohile;Charles S. Kamen;Ian R. Kleckner;Chunkit Fung;Matthew Asare;Calvin L. Cole;Eva Culakova;Karen M. Mustian
  • 通讯作者:
    Karen M. Mustian
1571: Adjuvant Intravesical Therapy and Improved Survival Among Elderly Patients with Superficial Bladder Cancer
  • DOI:
    10.1016/s0022-5347(18)31759-2
  • 发表时间:
    2007-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Benjamin A. Spencer;Supriya G. Mohile;Dawn Hershman;Jian Wang;Harry W. Herr;Mitchell C. Benson;Alfred I. Neugut
  • 通讯作者:
    Alfred I. Neugut
Using Information Technology in the Assessment and Monitoring of Geriatric Oncology Patients
  • DOI:
    10.1007/s11912-018-0672-3
  • 发表时间:
    2018-03-01
  • 期刊:
  • 影响因子:
    5.000
  • 作者:
    Kah Poh Loh;Colin McHugh;Supriya G. Mohile;Karen Mustian;Marie Flannery;Heidi Klepin;Rebecca Schnall;Eva Culakova;Erika Ramsdale
  • 通讯作者:
    Erika Ramsdale

Supriya G. Mohile的其他文献

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{{ truncateString('Supriya G. Mohile', 18)}}的其他基金

A Patient-Oriented Research Program in Geriatric Oncology
以患者为中心的老年肿瘤学研究项目
  • 批准号:
    10370333
  • 财政年份:
    2018
  • 资助金额:
    $ 35万
  • 项目类别:
A Patient-Oriented Research Program in Geriatric Oncology
以患者为中心的老年肿瘤学研究项目
  • 批准号:
    10590987
  • 财政年份:
    2018
  • 资助金额:
    $ 35万
  • 项目类别:
Understanding Treatment Tolerability in Older Patients with Cancer
了解老年癌症患者的治疗耐受性
  • 批准号:
    10240520
  • 财政年份:
    2018
  • 资助金额:
    $ 35万
  • 项目类别:
Understanding Treatment Tolerability in Older Patients with Cancer
了解老年癌症患者的治疗耐受性
  • 批准号:
    9789242
  • 财政年份:
    2018
  • 资助金额:
    $ 35万
  • 项目类别:
A Patient-Oriented Research Program in Geriatric Oncology
以患者为中心的老年肿瘤学研究项目
  • 批准号:
    9894704
  • 财政年份:
    2018
  • 资助金额:
    $ 35万
  • 项目类别:
Understanding Treatment Tolerability in Older Patients with Cancer
了解老年癌症患者的治疗耐受性
  • 批准号:
    10005899
  • 财政年份:
    2018
  • 资助金额:
    $ 35万
  • 项目类别:
Reducing Chemotherapy Toxicity in Older Adults
减少老年人的化疗毒性
  • 批准号:
    9097609
  • 财政年份:
    2013
  • 资助金额:
    $ 35万
  • 项目类别:
Reducing Chemotherapy Toxicity in Older Adults
减少老年人的化疗毒性
  • 批准号:
    8555036
  • 财政年份:
    2013
  • 资助金额:
    $ 35万
  • 项目类别:
Reducing Chemotherapy Toxicity in Older Adults
减少老年人的化疗毒性
  • 批准号:
    9319634
  • 财政年份:
    2013
  • 资助金额:
    $ 35万
  • 项目类别:
Reducing Chemotherapy Toxicity in Older Adults
减少老年人的化疗毒性
  • 批准号:
    8731840
  • 财政年份:
    2013
  • 资助金额:
    $ 35万
  • 项目类别:
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