Neurotoxic and neurodegenerative risks from chronic exposure to metal mixtures in e-cigarette aerosol
长期接触电子烟气溶胶中的金属混合物会产生神经毒性和神经退行性风险
基本信息
- 批准号:10883865
- 负责人:
- 金额:$ 7.32万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescentAdolescent and Young AdultAdverse effectsAerosolsAffectAirAldehydesAnalytical ChemistryAnimal ModelAnimalsAreaAuthorization documentationBloodBrainCalciumCarcinogensCardiac MyocytesCardiovascular DiseasesCardiovascular systemCell Culture TechniquesCell modelCessation of lifeCharacteristicsChromiumChronicCigaretteClinicalCognitionCognitive deficitsCopperCorpus striatum structureCotinineDataDevicesDiseaseDisease modelDoseElectronic cigaretteEnvironmental Engineering technologyEpidemiologyEtiologyExhibitsExposure toFlavoringGeneral PopulationGenetic DeterminismGenetic Predisposition to DiseaseGlycerolHealthHealth HazardsHeatingHumanImageImpaired cognitionIndividualInductively Coupled Plasma Mass SpectrometryInhalationIronKnock-inKnowledgeLRRK2 geneLaboratoriesLead levelsLengthLinkLiquid substanceManganeseMeasuresMediatingMetal exposureMetalsMotorMusMutationNerve DegenerationNeuritesNeurodegenerative DisordersNeuronsNeurotoxinsNickelNicotineParkinson DiseasePathologicPatientsPerceptionPhasePolicy MakerPredispositionPropylene GlycolsPublic HealthRecording of previous eventsReportingResearch PersonnelRespiratory DiseaseRiskRoleSamplingSeleniumSmokerSmokingSolventsSynapsesSystemTestingTobaccoToxic effectVanadiumYouthZincauthoritybasebrain healthbrain tissuecancer riskcarcinogenicitydensitydisorder riskdopaminergic neurone-cigarette aerosolselectronic cigarette useelectronic cigarette userelectronic liquidexposed human populationhuman subjectinduced pluripotent stem cellmotor deficitmotor impairmentmouse modelneurotoxicneurotoxicitynoveloperationparticleprematurepreventrespiratorysecondhand aerosolsporadic Parkinson&aposs Diseasetobacco smokersvapingvapor
项目摘要
PROJECT SUMMARY
Electronic cigarettes (e-cigs), battery-operated devices that heat liquids to generate an inhaled aerosol vapor,
are increasingly popular, especially among younger users. E-cigs are seen as an increasingly attractive
alternative to tobacco cigarettes; however, little is known about the human health effects arising from chronic
exposure to these aerosols. A growing number of studies have examined potential e-cig risks for cancer,
respiratory, and cardiovascular diseases. New data from our laboratory and others, however, raise additional
human health concerns about exposure to potentially neurotoxic metals released from the heated coil wire and
other e-cig components. For example, we found that in a large fraction e-cig aerosol samples we collected,
nickel, chromium, and lead levels exceeded EPA national ambient air quality standards or ATSDR minimum
risk levels (MRL). Notably, this was true for manganese (Mn), a prime suspect in sporadic Parkinson’s disease
(PD) etiology. Others have found that vanadium, copper and selenium (all suspected for a potential role in PD)
were higher in blood of e-cig users as compared to tobacco smokers. We hypothesize that hazardous metals
released by e-cigs may accumulate in the brain and pose significant neurotoxic risk(s) for neurodegenerative
diseases upon chronic exposure. We will test our hypothesis in three ways. First, we will determine the levels
of potentially neurotoxic metals in the aerosol produced by several popular e-cigs operated under different
conditions and with e-liquids differing in flavor and nicotine content. Second, we will examine the neurotoxic
effect of chronic e-cig aerosol exposure in neuronal cell cultures derived from human subjects carrying
incompletely-penetrant mutations linked to PD or from healthy controls, and identify metal mixtures of particular
neurotoxic concern. Third, we will measure metal concentrations in brain tissue of chronically e-cig exposed
mice, which are wildtype controls or knock-in for a mutation that increases the risk for PD; we will also
determine the metals’ potential adverse effects on motor function and cognition in the mouse models. Findings
from this study are likely to provide crucial and heretofore unavailable information to policy makers and will
enable them to evaluate potential neurotoxic health risks arising from second-hand exposure to e-cig aerosol.
We hypothesize that health risks are significantly influenced by genetic susceptibility to neurodegenerative
disease, as well as by e-cig device construction, operating conditions, e-liquid flavoring, and nicotine content.
项目摘要
电子香烟(e-cigs),电池驱动的加热液体以产生吸入的气溶胶蒸汽的装置,
越来越受欢迎,尤其是在年轻用户中。电子烟被视为一种越来越有吸引力的
烟草香烟的替代品;然而,对慢性吸烟引起的人类健康影响知之甚少。
暴露在这些烟雾中。越来越多的研究调查了电子烟对癌症的潜在风险,
呼吸道和心血管疾病。然而,来自我们实验室和其他实验室的新数据,
暴露于加热线圈金属丝释放的潜在神经毒性金属的人体健康问题,
其他电子烟组件。例如,我们发现,在我们收集的大部分电子烟气溶胶样本中,
镍、铬和铅的含量超过了EPA国家环境空气质量标准或ATSDR最低标准
风险水平(MRL)。值得注意的是,锰(Mn)是散发性帕金森病的主要嫌疑人,
(PD)病因学其他人发现,钒,铜和硒(所有怀疑在PD的潜在作用)
与吸烟者相比,电子烟使用者的血液中的我们假设有害金属
电子烟释放的尼古丁可在大脑中积聚,并对神经退行性疾病造成重大的神经毒性风险。
慢性暴露的疾病。我们将从三个方面来检验我们的假设。首先,我们将确定
几种流行的电子烟在不同的环境下工作产生的气溶胶中可能含有神经毒性金属,
条件和具有不同风味和尼古丁含量的电子液体。第二,我们将研究神经毒素
慢性电子烟气溶胶暴露对来自携带者的人类受试者的神经元细胞培养物的影响
与PD或健康对照相关的不完全渗透突变,并识别特定的金属混合物
神经毒性问题。第三,我们将测量长期暴露于电子烟的脑组织中的金属浓度。
小鼠,这是野生型对照或敲入突变,增加PD的风险;我们还将
在小鼠模型中确定金属对运动功能和认知的潜在不利影响。结果
这项研究可能会为决策者提供至关重要的、迄今为止无法获得的信息,
使他们能够评估二手接触电子烟气雾剂对健康造成的潜在神经毒性风险。
我们假设健康风险受到神经退行性疾病遗传易感性的显著影响,
疾病,以及电子烟装置构造、操作条件、电子液体调味剂和尼古丁含量。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Markus Hilpert其他文献
Markus Hilpert的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Markus Hilpert', 18)}}的其他基金
Neurotoxic and neurodegenerative risks from chronic exposure to metal mixtures in e-cigarette aerosol
长期接触电子烟气溶胶中的金属混合物会产生神经毒性和神经退行性风险
- 批准号:
10600594 - 财政年份:2021
- 资助金额:
$ 7.32万 - 项目类别:
Neurotoxic and neurodegenerative risks from chronic exposure to metal mixtures in e-cigarette aerosol
长期接触电子烟气溶胶中的金属混合物会产生神经毒性和神经退行性风险
- 批准号:
10483159 - 财政年份:2021
- 资助金额:
$ 7.32万 - 项目类别:
Neurotoxic and neurodegenerative risks from chronic exposure to metal mixtures in e-cigarette aerosol
长期接触电子烟气溶胶中的金属混合物会产生神经毒性和神经退行性风险
- 批准号:
10204524 - 财政年份:2021
- 资助金额:
$ 7.32万 - 项目类别:
Neurotoxic and neurodegenerative risks from chronic exposure to metal mixtures in e-cigarette aerosol
长期接触电子烟气溶胶中的金属混合物会产生神经毒性和神经退行性风险
- 批准号:
10655610 - 财政年份:2021
- 资助金额:
$ 7.32万 - 项目类别:
Tracking Metals From E-cigarettes: From The Coil Into Lung Tissue
追踪电子烟中的金属:从线圈到肺组织
- 批准号:
9788461 - 财政年份:2018
- 资助金额:
$ 7.32万 - 项目类别:
相似海外基金
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
- 批准号:
23K09542 - 财政年份:2023
- 资助金额:
$ 7.32万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The impact of changes in social determinants of health on adolescent and young adult mental health during the COVID-19 pandemic: A longitudinal study of the Asenze cohort in South Africa
COVID-19 大流行期间健康社会决定因素的变化对青少年和年轻人心理健康的影响:南非 Asenze 队列的纵向研究
- 批准号:
10755168 - 财政年份:2023
- 资助金额:
$ 7.32万 - 项目类别:
A Priority Setting Partnership to Establish a Patient, Caregiver, and Clinician-identified Research Agenda for Adolescent and Young Adult Cancer in Canada
建立优先合作伙伴关系,以建立患者、护理人员和临床医生确定的加拿大青少年和年轻人癌症研究议程
- 批准号:
480840 - 财政年份:2023
- 资助金额:
$ 7.32万 - 项目类别:
Miscellaneous Programs
Incidence and Time on Onset of Cardiovascular Risk Factors and Cardiovascular Disease in Adult Survivors of Adolescent and Young Adult Cancer and Association with Exercise
青少年和青年癌症成年幸存者心血管危险因素和心血管疾病的发病率和时间以及与运动的关系
- 批准号:
10678157 - 财政年份:2023
- 资助金额:
$ 7.32万 - 项目类别:
Fertility experiences among ethnically diverse adolescent and young adult cancer survivors: A population-based study
不同种族青少年和年轻成年癌症幸存者的生育经历:一项基于人群的研究
- 批准号:
10744412 - 财政年份:2023
- 资助金额:
$ 7.32万 - 项目类别:
Treatment development for refractory leukemia using childhood/adolescent, and young adult leukemia biobank
利用儿童/青少年和青年白血病生物库开发难治性白血病的治疗方法
- 批准号:
23K07305 - 财政年份:2023
- 资助金额:
$ 7.32万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular design of Two-Way Player CAR-T cells to overcome disease/antigen heterogeneity of childhood, adolescent, and young adult cancers
双向 CAR-T 细胞的分子设计,以克服儿童、青少年和年轻成人癌症的疾病/抗原异质性
- 批准号:
23H02874 - 财政年份:2023
- 资助金额:
$ 7.32万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Using Tailored mHealth Strategies to Promote Weight Management among Adolescent and Young Adult Cancer Survivors
使用量身定制的移动健康策略促进青少年和年轻癌症幸存者的体重管理
- 批准号:
10650648 - 财政年份:2023
- 资助金额:
$ 7.32万 - 项目类别:
Developing and Testing a Culturally Tailored Mobile Health and Social MediaPhysical Activity Intervention Among Adolescent and Young Adult ChildhoodCancer Survivors
开发和测试针对青少年和青年儿童癌症幸存者的文化定制移动健康和社交媒体体育活动干预
- 批准号:
10736526 - 财政年份:2023
- 资助金额:
$ 7.32万 - 项目类别:
Pilot Project 1: Creating Bridges to Reproductive Health Care for Rural Adolescent and Young Adult Cancer Survivors
试点项目 1:为农村青少年和青年癌症幸存者搭建生殖保健桥梁
- 批准号:
10762146 - 财政年份:2023
- 资助金额:
$ 7.32万 - 项目类别: