Jigsawdio: an AudioVisual Jigsaw Puzzle for People with Alzheimer's Disease and Alzheimer's-Disease-Related Dementias

与世隔绝会导致孤独，这与抑郁、压力、高血压和睡眠不良有关， 所有这些都会加速认知能力的下降。新冠肺炎造成的长期社会孤立 大流行进一步突出了社会联系的重要性。制定新战略以支持 AD/ADRD患者及其家人是公共卫生的优先事项，特别是在社会和家庭联系 都被打乱了。Jigsawdio制作了一款结合了照片和音频的视听拼图 可以单独完成或与他人一起完成的记忆的记录。单独的片段用 设置到位时播放的自定义音频录音。我们的产品创新是由 几个前提。首先，根据阿尔茨海默氏症协会的研究，记忆护理研究表明，即使 患有ADRD的人可能不再认识所爱的人，他们在一起的时间会产生持久的、积极的影响。 其次，研究表明，AD/ADRD患者的情绪状态可以通过怀旧得到支持 和回忆。尽管认知受损，但AD/ADRD患者在某种程度上会体验到怀旧 与未受损的成年人相似。回忆疗法(RT)利用记忆和过去的经验与有形的 提示，如照片或音乐，以唤起记忆和刺激对话。对于AD/ADRD患者， RT已被证明对生活质量、沟通和情绪有积极影响。第三，有机会 唤起情绪记忆的社会经历可以改善AD/ADRD患者的情绪和减少焦虑 病人。第四，拼图游戏已被证明可以减少压力和焦虑。专注于拼图可以提供 从压力中“喘息”，可以通过乐趣、流畅和驾驭来提升情绪。因为大流行， 社会参与活动是迫切需要的。Jigsawdio之前开发了一种可录制的音频 为一般用途而设计的拼图原型。为了将本产品翻译给AD/ADRD用户，我们组装了一个 在讲故事，怀旧，AD/ADRD心理学，AD/RD用户的技术开发方面拥有专业知识的团队， 以及幸福和幸福的心理决定因素。这项第一阶段建议的总体目标是 进行访谈以创建故事情节，为AD/ADRD患者开发最低可行的产品，并进行 一项对居住在记忆护理设施中的参与者进行的可用性和可接受性研究。为了实现这些目标， 我们将完成以下目标：1)对家庭、照顾者和设施工作人员进行深入访谈，以 收集值得纪念的事件的故事，并为每个记忆护理住院医生创建多个故事情节。2)发展 为记忆护理住院医生定制视听拼图游戏。Jigsawdio团队将设计和设计 由专为AD/ADRP用户设计的硬件和软件组成的MVP。3)确定可行性和 对于记忆护理居民来说，这款拼图游戏的可用性。我们第一阶段项目的成功将使我们能够完善 基于用户反馈为AD/ADRD用户提供Jigsawdio MVP，并进行大规模用户临床试验 评估Jigsawdio对情绪健康、焦虑、抑郁和焦虑的影响。

Social isolation leads to loneliness, which is linked to depression, stress, high blood pressure, and poor sleep, all of which accelerate cognitive decline. The prolonged social isolation that resulted from the COVID-19 pandemic has further highlighted the importance of social connection. Developing new strategies to support AD/ADRD patients and their families is a public health priority, particularly when social and family connections are disrupted. Jigsawdio has created an audiovisual jigsaw puzzle that combines photographs and audio recordings of memories that can be completed alone or with others. Individual pieces are encoded with customized audio recordings that play when the piece is set into place. Our product innovation is driven by several premises. First, according to the Alzheimer’s Society, memory care research shows that even though a person with ADRD may no longer recognize a loved one, their time together has a lasting, positive impact. Second, studies have shown that the emotional state of AD/ADRD patients can be bolstered through nostalgia and reminiscence. Despite being cognitively impaired, people with AD/ADRD experience nostalgia in a manner similar to non-impaired adults. Reminiscence therapy (RT) uses memories and past experiences with tangible prompts, such as photographs or music, to evoke memories and stimulate conversation. For AD/ADRD patients, RT has been shown to have positive effects on quality of life, communication, and mood. Third, opportunities for social experiences that evoke emotional memories can improve mood and decrease agitation in AD/ADRD patients. Fourth, jigsaw puzzles have been shown to reduce stress and agitation. Focusing on a puzzle provides a “breather” from stress and can enhance mood through fun, flow, and mastery. Because of the pandemic, socially engaging activities are desperately needed. Jigsawdio has previously developed a recordable audio puzzle prototype designed for general use. To translate this product for AD/ADRD users, we have assembled a team with expertise in storytelling, nostalgia, AD/ADRD psychology, technology development for AD/RD users, and mental determinants of well-being and happiness. The overall objective of this Phase I STTR proposal is to conduct interviews to create storylines, develop a minimum viable product for AD/ADRD patients, and conduct a usability and acceptability study with participants living in a memory care facility. To achieve these objectives, we will complete the following aims: 1) Conduct in-depth interviews with families, caregivers, and facility staff to collect stories of memorable events and create multiple storylines for each memory care resident. 2) Develop customized audiovisual jigsaw puzzles for memory care residents. The Jigsawdio team will design and engineer an MVP consisting of hardware and software designed for AD/ADRP users. 3) Determine the feasibility and usability of the puzzles for memory care residents. The success of our Phase I project will allow us to refine the Jigsawdio MVP for AD/ADRD users based on user feedback and engage in a large-scale user clinical trial to evaluate the effects of Jigsawdio on emotional well-being, agitation, depression, and anxiety.