Mechanisms of ataxia in spinocerebellar ataxia type 1 transgenic mice

脊髓小脑共济失调1型转基因小鼠的共济失调机制

• 批准号: nhmrc : 1049536
• 负责人: Prof Elsdon Storey
• 金额: $ 24.08万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-ataxia-spinocerebellar-transgenic-mice/112089
• 关键词: Mechanisms; ataxia; spinocerebellar; type; transgenic

Degeneration of the coordination part of the brain (cerebellum) causes ATAXIA. There are many types, but few can be cured. The majority, affecting ~ 3,000 Australians, are progressive, and can only be helped by physical therapies. We are searching for a drug to improve the SYMPTOMS of ataxia, by analysing the chemical transmitters in the cerebellum in genetically ataxic mice. If we find an imbalance, we will trial appropriate drugs to try to correct this and lessen ataxia.

大脑协调部分（小脑）的退化导致共济失调。有很多类型，但很少能治愈。大多数影响到约3，000名澳大利亚人，是渐进的，只能通过物理治疗来帮助。我们正在通过分析遗传性共济失调小鼠小脑中的化学递质来寻找改善共济失调症状的药物。如果我们发现失衡，我们将尝试适当的药物来纠正这种情况并减轻共济失调。