Development and Pilot Randomized Control Trial of a Text Message Intervention to Facilitate Secure Storage and Disposal of Prescription Opioids to Prevent Diversion and Misuse

短信干预的开发和试点随机控制试验，以促进处方阿片类药物的安全存储和处置，以防止转移和滥用

• 批准号: 10893197
• 负责人: Kathleen Louise Egan
• 金额: $ 19.52万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10893197
• 关键词: Acute Pain; Address; Adopted; Awareness; Cellular Phone; Communities; Control Groups; County; Development; Drug Prescriptions; Education; Equation; Evidence based intervention; Failure; Focus Groups; Friends; Funding Mechanisms; Goals; Health behavior; Healthcare Systems; Home; Individual; Intervention; Knowledge; Learning; Letters; Modality; Modeling; Morbidity - disease rate; Motivation; National Institute of Drug Abuse; Opioid; Opioid Analgesics; Outcome; Overdose; Pamphlets; Participant; Patient Recruitments; Patients; Persons; Pharmaceutical Preparations; Pharmacy facility; Phase; Population; Prevalence; Procedures; Process; Public Health; Randomized; Randomized, Controlled Trials; Reminder Systems; Reporting; Research; Sampling; Secure; Series; Site; Source; System; Target Populations; Technology; Testing; Text Messaging; Time; United States; United States Substance Abuse and Mental Health Services Administration; Unused prescription; aged; care systems; combat; communication behavior; comparison control; expiration; feasibility testing; health belief; health care settings; implementation trial; injury-related death; innovation; mobile computing; mortality; nonmedical use; novel; opioid disposal; opioid epidemic; pilot test; prescription opioid; prescription opioid misuse; prevent; preventive intervention; programs; recruit; research study; standard of care; text messaging intervention; theories

Project Summary The existing supply of opioid analgesics is high; the prescribing rate equates to at least one opioid prescription per resident in the highest prescribing counties. Many of these opioid analgesics go unused and are kept in homes rather than disposed after ceasing use. The primary source of prescription opioids for nonmedical use is relatives or friends; which suggests that diversion of excess and retained prescription opioids contribute significantly to nonmedical use and associated consequences. Without effective strategies to facilitate their secure storage and disposal, prescription opioids will remain in communities, increasing the likelihood for nonmedical use-related morbidity and mortality. The long-term goal is to prevent nonmedical prescription opioid use by decreasing availability of unused medications in the home. The overall objective of this R34 application is to test the feasibility of a novel, evidence-informed strategy that utilizes a series of persuasive, informational text message reminders to expand the impact of secure storage and disposal programs. This research study will pursue two specific aims (1) use communications and health behavior theory to develop and refine a text message intervention to encourage secure storage and disposal of unused prescription opioids; and (2) pilot test the text message intervention, developed under Aim 1, to facilitate secure storage and disposal of unused opioid analgesics. For Aim 1, a systematic two-phase process will be used to develop and refine a text message intervention informed by the Message Impact Framework and the Health Belief Model. Phase 1 will consist of focus group discussions (n=6-8 FGDs, n=7-10 individuals per FGD) with the target population of individuals prescribed opioid medications for acute pain. Phase 2 consists of pretesting and refining the text message intervention using a nationally representative panel sample (n=1,500). For Aim 2, a randomized control trial will be conducted with 360 participants recruited from a local pharmacy when an opioid prescription is dispensed. This project is innovative in that it shifts the current paradigm by (1) adapting an evidence-based intervention strategy, SMS text messages on mobile phones, for a novel purpose – facilitation of secure storage and disposal of prescription opioids, (2) using theoretically driven messaging to deliver a text message intervention during a critical window of need following receipt of a prescription opioid medication, and (3) testing an intervention platform to address nonmedical prescription opioid use that is scalable across multiple systems of care. The proposed research is significant because it should reduce the accumulation of unused prescription opioids from patients’ homes and, subsequently, contribute to a decline in the prevalence of nonmedical prescription opioid use and associated consequences. The proposed study directly addresses NIDA’s priorities by developing and pretesting a theoretically-based, prevention intervention which can be implemented in healthcare settings to elicit population-level impacts to address the opioid crisis.

项目摘要 阿片类镇痛剂的现有供应量很高;处方率相当于至少一个阿片类处方 每名居民的平均死亡人数这些阿片类镇痛药中有许多未被使用， 而不是在停止使用后处理。非医疗用途处方阿片类药物的主要来源 是亲戚或朋友;这表明过量和保留的处方阿片类药物的转移有助于 严重影响非医疗用途和相关后果。如果没有有效的战略来促进他们的 安全储存和处置，处方阿片类药物将留在社区，增加了 非医疗使用相关的发病率和死亡率。长期目标是防止非医疗处方 通过减少家中未使用药物的可用性来减少阿片类药物的使用。R34的总体目标 应用是为了测试一种新颖的，循证策略的可行性，该策略利用一系列有说服力的， 信息短信提醒，以扩大安全存储和处置计划的影响。这 研究将追求两个具体目标（1）利用传播和健康行为理论， 并完善短信干预，鼓励安全存储和处理未使用的处方 阿片类药物;以及（2）对根据目标1开发的短信干预进行试点测试，以促进安全存储 以及处置未使用的阿片类镇痛药。对于目标1，将采用系统的两阶段进程， 并根据消息影响框架和健康信念改进短信干预措施 模型第1阶段将包括焦点小组讨论（n=6-8个FGD，每个FGD n=7-10人）， 针对急性疼痛开具阿片类药物的目标人群。第二阶段包括预测试 以及使用全国代表性小组样本（n= 1，500）来改进文本消息干预。为宗旨 2，随机对照试验将在当地药房招募360名参与者， 阿片类药物处方被分发。该项目的创新之处在于它通过以下方式改变了当前的范式：（1）适应 一个基于证据的干预策略，移动的手机上的短信，用于一个新的目的- 促进处方阿片类药物的安全储存和处置，（2）使用理论驱动的信息传递， 在收到处方阿片类药物后的关键需求窗口期间提供短信干预 （3）测试干预平台，以解决非医疗处方阿片类药物的使用， 可扩展到多个护理系统。拟议的研究是重要的，因为它应该减少 从患者家中积累未使用的处方阿片类药物，随后导致 非医疗处方阿片类药物使用的流行率及其相关后果。拟定研究 通过开发和预先测试基于理论的预防干预措施，直接解决NIDA的优先事项 这可以在医疗保健环境中实施，以引起人口水平的影响，以解决阿片类药物危机。

项目成果

Rates and correlates of medicine disposal program implementation at pharmacies in North Carolina: A longitudinal study, 2016-2021.

• DOI: 10.1016/j.japh.2022.03.002
• 发表时间: 2022-07
• 期刊: JOURNAL OF THE AMERICAN PHARMACISTS ASSOCIATION
• 影响因子: 2.1
• 作者: Egan, Kathleen L.;Johnston, Carol A.;Jackson, Jeffrey T.;Foster, Samantha E.;Lee, Joseph G. L.
• 通讯作者: Lee, Joseph G. L.