PHYSIOLOGY AND PHARMACOLOGY OF OPIOIDS IN BRAIN
脑中阿片类药物的生理学和药理学
基本信息
- 批准号:2443457
- 负责人:
- 金额:$ 12.94万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1992
- 资助国家:美国
- 起止时间:1992-07-01 至 2000-05-31
- 项目状态:已结题
- 来源:
- 关键词:biological signal transduction calcium channel cholecystokinin electrophysiology endogenous opioid gamma aminobutyrate hippocampus inhibitor /antagonist interneurons laboratory rat neural transmission neurochemistry neuropeptides nitric oxide opioid receptor periaqueductal gray matter stimulant /agonist tissue /cell culture voltage gated channel
项目摘要
Opioids are known to have important behavioral and physiological actions
that are mediated by interactions with neurons in the central nervous
system. However, while the behavioral actions of the opioids, including
analgesia and euphoria, are well-known, the functional roles these
molecules play as neuromodulators in the mammalian brain remain poorly
understood. The following experiments will evaluate the actions of
opioids, acting at pharmacologically defined mu-, delta- and kappa-opioid
receptor subtypes, as modulators of synaptic transmission in the CA1 and
dentate gyrus regions of the hippocampus, and in another brain region
known as the periaqueductal gray. The experiments described in this
proposal will utilize whole-cell patch clamp electrophysiological
techniques to examine the effects of opioids on individual neurons in rat
brain slice preparations. The first set of experiments will focus on the
mechanisms through which mu-, delta-, and kappa-opioid receptor agonists
act to decrease evoked and spontaneous synaptic transmission in the
hippocampal slice. In particular, these experiments will examine the
contributions made by distinct voltage-dependent calcium channels,
intracellular calcium stores, and nitric oxide in supporting synaptic
transmission and the modulation of this process. The second set of
experiments will determine the effects of opioid agonists directly on
subpopulations of gamma-aminobutyric acid (GABA)-containing neurons
(interneurons) in the CA1 region of the hippocampus, and the cellular
mechanisms these receptors utilize to affect these cells. These
experiments will be aided through the use of differential interference
contrast microscopy to identify these neurons in living brain slices. The
third set of experiments will determine what mechanisms account for the
ability of certain non-opioid peptides to attenuate the behavioral and
cellular actions of the opioids. Thus, we will determine the effects of
the peptides cholecystokinin (CCK) and neuropeptide FF on neurons found in
the hippocampus, and the periaqueductal gray. The investigations described
in this grant proposal should improve our understanding of the specific
receptor subtypes that the opioids act upon, the cellular mechanisms
mediating their responses, the roles opioids may play as neuromodulators
in the brain, and the mechanism of their interaction with other non-opioid
peptides. in addition, since limbic structures like the hippocampus have
been shown to participate in normal and abnormal behavioral states such as
learning, epilepsy, and emotional behavior, and the periaqueductal gray
has been shown to be important in mediating opioid analgesia, these
studies may yield new insights as to the interaction between opioids and
these phenomena.
众所周知,阿片类药物具有重要的行为和生理作用
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Carl R. Lupica其他文献
Absence of sex differences in serotonergic control of orbitofrontal cortex neuronal activity
血清素能对眶额叶皮质神经元活动的控制中不存在性别差异
- DOI:
10.1038/s41598-025-11208-2 - 发表时间:
2025-07-17 - 期刊:
- 影响因子:3.900
- 作者:
Kailin M. Mooney;Alexander F. Hoffman;Carl R. Lupica - 通讯作者:
Carl R. Lupica
Carl R. Lupica的其他文献
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{{ truncateString('Carl R. Lupica', 18)}}的其他基金
PHYSIOLOGY AND PHARMACOLOGY OF OPIOIDS IN BRAIN
脑中阿片类药物的生理学和药理学
- 批准号:
2120217 - 财政年份:1992
- 资助金额:
$ 12.94万 - 项目类别:
PHYSIOLOGY AND PHARMACOLOGY OF OPIOIDS IN BRAIN
脑中阿片类药物的生理学和药理学
- 批准号:
2120216 - 财政年份:1992
- 资助金额:
$ 12.94万 - 项目类别:
PHYSIOLOGY AND PHARMACOLOGY OF OPIOIDS IN BRAIN
脑中阿片类药物的生理学和药理学
- 批准号:
2897879 - 财政年份:1992
- 资助金额:
$ 12.94万 - 项目类别:
Effect Of Drugs of Abuse On Synaptic Transmission In Nucleus Accumbens
滥用药物对伏核突触传递的影响
- 批准号:
8933812 - 财政年份:
- 资助金额:
$ 12.94万 - 项目类别:
Cocaine Addiction and the Role of Serotonin in Orbitofrontal Cortex Function
可卡因成瘾和血清素在眶额皮层功能中的作用
- 批准号:
8933873 - 财政年份:
- 资助金额:
$ 12.94万 - 项目类别:
Physiology of mitochondrial dysfunction in genetic models of Parkinson's disease
帕金森病遗传模型中线粒体功能障碍的生理学
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7733846 - 财政年份:
- 资助金额:
$ 12.94万 - 项目类别:
Effect Of Drugs of Abuse On Synaptic Transmission In Nucleus Accumbens
滥用药物对伏核突触传递的影响
- 批准号:
8148510 - 财政年份:
- 资助金额:
$ 12.94万 - 项目类别:
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