ETHANOL AND CD4 CELL DEPENDENT IMMUNITY

乙醇和 CD4 细胞依赖性免疫

基本信息

  • 批准号:
    2384348
  • 负责人:
  • 金额:
    $ 11.34万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1997
  • 资助国家:
    美国
  • 起止时间:
    1997-07-01 至 1999-06-30
  • 项目状态:
    已结题

项目摘要

Ethanol consumption in humans and in experimental animals has been shown to depress many specific immune functions. It has been hypothesized that the depressed immune response may contribute to the increased prevalence of infectious diseases and tumors in alcoholics. Studies suggest that chronic ethanol consumption depresses T-lymphocyte helper function. CD4 T- helper cells can be divided into two distinct phenotypic subsets acting through different lymphokine secretion patterns. Th1 cells give rise to cell-mediated immunity; Th2 are responsible for antibody-mediated immunity. Parasitic infections in mice provide the premier examples of infections controlled exclusively by either the Thl or the Th2 system. Two of these models have been thoroughly investigated, (a) Leishmania major, a protozoan infection, where immunity is totally Thl dependent and (b)Strongyloides stercoralis, a nematode infection, where immunity is totally Th2 dependent. The effect of ethanol consumption on the development of protective immunity to these infections will be determined, thereby elucidating the effect of ethanol on Thl and Th2 function. The objectives of this study are to (i) to determine the appropriate protocol for the administration of ethanol to mice for the demonstration of an effect on CD4 cell function (ii) to determine the effect of ethanol on protective immune responses dependent on either Thl or Th2 cells and (iii) to investigate the mechanism by which ethanol causes an alteration in the protective immune response. The results obtained with these two parasitic infection models will provide information on the effects of ethanol consumption on protective immunity dependent on CD4 cells.
人类和实验动物的乙醇消耗量

项目成果

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DAVID ABRAHAM其他文献

DAVID ABRAHAM的其他文献

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{{ truncateString('DAVID ABRAHAM', 18)}}的其他基金

Mechanisms and Treatment of Chronic, Latent Human Strongyloidiasis
慢性、潜伏性人类类圆线虫病的机制和治疗
  • 批准号:
    8508358
  • 财政年份:
    2013
  • 资助金额:
    $ 11.34万
  • 项目类别:
Mechanisms and Treatment of Chronic, Latent Human Strongyloidiasis
慢性、潜伏性人类类圆线虫病的机制和治疗
  • 批准号:
    9232990
  • 财政年份:
    2013
  • 资助金额:
    $ 11.34万
  • 项目类别:
Mechanisms and Treatment of Chronic, Latent Human Strongyloidiasis
慢性、潜伏性人类类圆线虫病的机制和治疗
  • 批准号:
    8627543
  • 财政年份:
    2013
  • 资助金额:
    $ 11.34万
  • 项目类别:
Neutrophil Dependent Immunity to Strongyloides Stercoralis
对粪类圆线虫的中性粒细胞依赖性免疫
  • 批准号:
    7885776
  • 财政年份:
    2009
  • 资助金额:
    $ 11.34万
  • 项目类别:
ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
嗜酸性粒细胞在粪圆线虫免疫中的作用
  • 批准号:
    6475539
  • 财政年份:
    2000
  • 资助金额:
    $ 11.34万
  • 项目类别:
ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
嗜酸性粒细胞在粪圆线虫免疫中的作用
  • 批准号:
    6261161
  • 财政年份:
    2000
  • 资助金额:
    $ 11.34万
  • 项目类别:
ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
嗜酸性粒细胞在粪圆线虫免疫中的作用
  • 批准号:
    6624554
  • 财政年份:
    2000
  • 资助金额:
    $ 11.34万
  • 项目类别:
ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
嗜酸性粒细胞在粪圆线虫免疫中的作用
  • 批准号:
    6888439
  • 财政年份:
    2000
  • 资助金额:
    $ 11.34万
  • 项目类别:
ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
嗜酸性粒细胞在粪圆线虫免疫中的作用
  • 批准号:
    6683181
  • 财政年份:
    2000
  • 资助金额:
    $ 11.34万
  • 项目类别:
ROLE OF EOSINOPHILS IN IMMUNITY TO S STERCORALIS
嗜酸性粒细胞在粪圆线虫免疫中的作用
  • 批准号:
    6828239
  • 财政年份:
    2000
  • 资助金额:
    $ 11.34万
  • 项目类别:

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