SEATTLE BREAST CANCER RESERCH PROGRAM

要求提供资金，在弗雷德·哈钦森癌症研究中心内开展工作 中心的一项多学科乳腺癌研究计划，名为 西雅图乳腺癌研究计划。该计划的目的将是 鼓励创新的多学科研究，特别是 提供对影响正常的因素的更多了解 乳腺上皮细胞的生长和调节、肿瘤的促进和 现有癌症的进展。据推测，这些知识将 导致初级预防的方法，并改进识别 癌前病变和早期肿瘤损害，因此也是更好的方法 二级预防和治疗。这些目的将通过以下方式实现 加强多个部门的调查人员之间的沟通和协作 通过研讨会、务虚会和联合试点项目以及通过 确定招聘更多调查员的需要 来自目前在我们癌症中心没有充分代表性的学科。 我们中心的一个独特之处是现有人口的优势 资源和研究。另一个主要优势是质量和多样性 现有的基于实验室的细胞和分子研究 在人类和非人类系统中都是如此。通过提议的计划 我们建议的活动是加强现有联系并开发新的 将这两个一般调查领域联系起来的合作研究， 并将这些努力集中在乳腺癌的研究上。我们的指挥能力 在多个定义的人群中进行的研究将提高有效性和 我们的结果对其他环境的适用性。此外，还可以访问 为患有乳腺癌或乳腺癌高危女性提供服务的诊所将提供 临床问题转化活动的机会。平面图和 长期维持这一计划的机构承诺 都被描述了。

Funds are requested, to develop within the Fred Hutchinson Cancer Research Center a multidisciplinary breast cancer research program, named the Seattle Breast Cancer Research Program. The purpose of the program will be to stimulate innovative multidisciplinary research designed especially to provide a greater understanding of the factors that influence normal mammary epithelial cell growth and regulation, tumor promotion, and progression of existing carcinomas. It is assumed that such knowledge will lead to methods of primary prevention, and to improved methods to identify precancerous and early neoplastic lesions and hence also to better methods of secondary prevention and treatment. These purposes will be achieved by enhancing communication and collaboration among investigators in multiple fields through seminars, retreats, and joint pilot projects, and through the identification of needs for the recruitment of additional investigators from disciplines not adequately represented currently in our cancer center. A unique feature of our center is the strength of existing population-based resources and research. Another major strength is the quality and diversity of existing laboratory-based investigations at the cellular and molecular level in both human and non-human systems. Through the proposed program activities we propose to strengthen existing links and develop new collaborative studies that bridge these two general investigative areas, and focus these efforts on studies of breast cancer. Our ability to conduct studies in multiple defined populations will enhance the validity and applicability of our results to other setting. In addition, access to clinics that serve women with or at high risk of breast cancer will provide opportunities for translational activities to clinical problems. Plans and an institutional commitment to sustain this program on a permanent basis are described.