DIET, CELL PROLIFERATION AND BREAST CANCER IN SHANGHAI

上海的饮食、细胞增殖和乳腺癌

• 批准号: 6173236
• 负责人: David B Thomas
• 金额: $ 64.04万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6173236
• 关键词: antioxidants; blood chemistry; breast neoplasms; cell proliferation; clinical research; diet; disease /disorder proneness /risk; histology; human subject; immunocytochemistry; interview; mammary gland; neoplasm /cancer classification /staging; neoplasm /cancer epidemiology; nutrition related neoplasm /cancer; nutrition related tag; phytoestrogens; plant extracts; women's health

DESCRIPTION: The assumption on which this application is based is that factors that enhance mammary cell proliferation act to promote the development of breast cancer, and factors that inhibit proliferation serve as anti-promoters. Several dietary factors have been posited to influence mammary epithelial cell proliferation. The overall goals of the proposed study are to identify associations between various dietary factors and proliferation, as demonstrated histologically and by direct tissue assays, in benign fibrocystic breast lesions and in the mammary epithelium adjacent to both benign and malignant breast tumors. There are also plans to compare dietary factors in women with malignant and proliferative benign breast lesions, accounting for histologic evidence of proliferative changes in the surrounding non-tumorous tissue. Study subjects will be selected from among over 267,000 female textile workers in Shanghai, who were enrolled in 1988-89 in a randomized trial of breast self-examination (BSE). Women in this cohort, who, during a 5-year period, develop breast cancer or fibrocystic lesions, and normal age-matched controls selected from the cohort, will be interviewed to obtain information on risk factors for breast cancer, frequency of intake of multiple foods, recent dietary changes and recent intake of phytoestrogen-rich foods. All data will be gathered prior to diagnosis. Blood specimens will be collected and assayed for various lipids, antioxidant vitamins, and isoflavones. Histologic slides from all cases will be collected, the lesions will be classified, and both the benign lesions and normal tissue will be evaluated for various morphologic and immunocytochemical indicators of ductal and lobular proliferation. Unlike prior studies, consumption of foods in this study sample covers a range over which not only breast cancer rates are expected to vary widely, but also phytoestrogen consumption is high, providing an opportunity to evaluate their role in breast cancer. Also unlike prior epidemiologic studies of diet and breast cancer, in the proposed investigation the primary end points are various indices of cell proliferation.

描述：此应用程序所基于的假设是 促进乳腺细胞增殖的因素作用于促进 乳腺癌的发展和抑制增殖的因素起作用 作为反推动者。有几个饮食因素被认为会影响 乳腺上皮细胞增殖。建议的总体目标 研究是确定不同饮食因素和 增殖，正如组织学和直接组织分析所证明的那样， 乳腺良性纤维囊性病变及其邻近的乳腺上皮 良性和恶性乳腺肿瘤。也有计划进行比较 恶性和增生性乳腺良性病变患者的饮食因素分析 病变，占增殖性改变的组织学证据 周围的非肿瘤组织。研究对象将从以下各项中选择 上海有26.7万多名纺织女工参加了 1988-1989年在一项乳房自我检查(BSE)的随机试验中。女性穿着 这群人在5年内患上乳腺癌或 纤维囊性病变和年龄匹配的正常对照，选自 队列，将接受采访以获得有关乳房风险因素的信息 癌症、摄入多种食物的频率、最近的饮食变化以及 最近摄入了富含植物雌激素的食物。所有数据都将事先收集 去做诊断。血液样本将被收集并检测各种不同的 脂类、抗氧化维生素和异黄酮类。来自All的组织切片 将收集病例，对病变进行分类，并将良性和 损伤和正常组织将被评估各种形态和 导管和小叶增殖的免疫细胞化学指标。不像 先前的研究表明，本研究样本中的食物消费范围超过 这不仅乳腺癌发病率预计会有很大的差异，而且 植物雌激素消耗量很高，这为评估提供了机会 它们在乳腺癌中的作用。也不同于以前的流行病学研究 饮食与乳腺癌，在建议调查的主要终点 是细胞增殖的各种指标。