AUTOMATED ANALYSIS OF NMR SPECTRA OF URINE

尿液核磁共振谱的自动分析

基本信息

  • 批准号:
    2023426
  • 负责人:
  • 金额:
    $ 10万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1997
  • 资助国家:
    美国
  • 起止时间:
    1997-07-01 至 1997-12-31
  • 项目状态:
    已结题

项目摘要

NMR spectroscopy of urine samples provides accurate and fast detection of a large number of metabolites that are indicative of a variety of inherited metabolic diseases. This diagnostic may be extremely useful both for screening of asymptomatic, healthy children and for rapid diagnosis of sick children under urgent care. However, the interpretation of the NMR spectra remains a manual task requiring a highly skilled, medically trained spectroscopist. If the spectrum is complicated, manual interpretation time can far exceed sample preparation and data acquisition time. In Phase I, ORINCON proposes to design and implement a software package to automate the interpretation of NMR spectra of urine in terms of concentrations of abnormal metabolites. The analysis program will assign the absorption resonances to the metabolic compounds of interest, and the concentrations of metabolites will be obtained from spectral intensities. The identification of metabolites will be aided by a database of reference NMR spectra for a basic set of pure metabolites. It is anticipated that in Phase II of this program ORINCON will implement complete, user-friendly analysis software that will, with minimum intervention by the operator, interpret the NMR spectra in terms of the metabolite concentrations and the probabilities of metabolic disorders associated with the presence of these metabolites. PROPOSED COMMERCIAL APPLICATION Software for automated analysis of NMR spectra will be a commercially viable product with application in newborn screening programs and infant intensive care units for the diagnosis of inherited metabolic diseases, as well as for development of other medical diagnostic tools based on NMR spectroscopy of urine, cerebrospinal fluid, plasma, bile, semen, and amniotic fluid. The algorithms developed here may also find commercial application in atomic and molecular spectroscopy.
尿液样本的核磁共振光谱提供准确和快速的检测

项目成果

期刊论文数量(0)
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会议论文数量(0)
专利数量(0)

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Dariusz Wroblewski其他文献

Dariusz Wroblewski的其他文献

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{{ truncateString('Dariusz Wroblewski', 18)}}的其他基金

Computational framework for analysis of microarray gene expression data
微阵列基因表达数据分析的计算框架
  • 批准号:
    7537700
  • 财政年份:
    2009
  • 资助金额:
    $ 10万
  • 项目类别:
Head mounted display apparatus for visual field test
用于视野测试的头戴式显示装置
  • 批准号:
    6831800
  • 财政年份:
    2004
  • 资助金额:
    $ 10万
  • 项目类别:
Head mounted display apparatus for visual field test
用于视野测试的头戴式显示装置
  • 批准号:
    7405540
  • 财政年份:
    2004
  • 资助金额:
    $ 10万
  • 项目类别:
Head mounted display apparatus for visual field test
用于视野测试的头戴式显示装置
  • 批准号:
    7561718
  • 财政年份:
    2004
  • 资助金额:
    $ 10万
  • 项目类别:
Head mounted display apparatus for visual field test
用于视野测试的头戴式显示装置
  • 批准号:
    7030747
  • 财政年份:
    2004
  • 资助金额:
    $ 10万
  • 项目类别:
Diagnostic Aid Software for Visual Field Test
视野测试诊断辅助软件
  • 批准号:
    6582662
  • 财政年份:
    2003
  • 资助金额:
    $ 10万
  • 项目类别:
Knowledge discovery portal for biomedical research
生物医学研究的知识发现门户
  • 批准号:
    6689165
  • 财政年份:
    2003
  • 资助金额:
    $ 10万
  • 项目类别:
Diagnostic aid software for the visual field test
用于视野测试的诊断辅助软件
  • 批准号:
    7120029
  • 财政年份:
    2002
  • 资助金额:
    $ 10万
  • 项目类别:
Diagnostic aid software for the visual field test
用于视野测试的诊断辅助软件
  • 批准号:
    6882489
  • 财政年份:
    2002
  • 资助金额:
    $ 10万
  • 项目类别:
EXPERT HYBRID SYSTEM FOR PREDICTION OF PROTEIN STRUCTURE
用于预测蛋白质结构的专家混合系统
  • 批准号:
    2536717
  • 财政年份:
    1998
  • 资助金额:
    $ 10万
  • 项目类别:
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