ESTROGEN AND MEMORY STABILITY IN OLDER WOMEN

老年女性的雌激素和记忆稳定性

• 批准号: 2034655
• 负责人: KAREN E MOE
• 金额: $ 7.24万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 1998-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2034655
• 关键词: clinical research; clinical trials; cortisol; estrogens; female; hormone therapy; human subject; human therapy evaluation; memory; menopause; progesterone

DESCRIPTION (Adapted from applicant's abstract): Menopause results in the dramatic decline of estrogen and progesterone. Converging evidence suggestive that low estrogen replacement therapy (ERT). ERT seems to improve memory in many older women. However, these studies are confounded by several factors. Also, effects of progesterone on cognition in older women have been virtually ignored, though it declines in parallel with estrogen. Many studies suggest that cortisol, another steroid, also influences cognition during aging. Together, variations in these hormones may help explain much of the individual variation in age-related cognitive decline. No studies have correlated endogenous estrogen, progesterone, or cortisol levels in post-menopausal women with objective cognitive performance. Here, levels of estrogen, progesterone, and cortisol will be measured in healthy older women participating in another longitudinal study of cognition. Cognitive status of the subjects ranges from youthful, control levels to mild dementia. The proposed work will compare endogenous hormone levels with contemporaneous cognition and longitudinal cognitive profile over the preceding 4 years. Women on ERT will be compared with women not taking estrogen supplements. Interaction of the hormones in their relationship to cognition will also be examined. This work will help establish the levels of estrogen associated with optimal memory maintenance and/or protection from age-related memory problems in women. Oral ERT as currently prescribed often results in supra-physiological levels of estrogens, with attendant unwanted side effects. Such high levels may be necessary for treatment of peri-menopausal symptoms (e.g., hot flashes) but perhaps not for prophylactic treatment of age-related cognitive decline. Moreover, post-menopausal women with an intact uterus are increasingly being advised for health reasons to take progesterone supplements with ERT. Therefore, it is important to understand possible interactions between estrogen and other hormones (progesterone, cortisol) in influencing cognition. The principal investigator is developing a long-term research program on ovarian steroids and the neurobiology of aging, with an initial focus on estrogen effects on cognition. The data collected will help guide the design of a planned ERT intervention study of healthy older women, by identifying appropriate estrogen target levels (i.e, associated with good cognition).

描述(摘自申请者的摘要)：更年期导致 雌激素和黄体酮急剧下降。汇聚证据 建议采用低雌激素替代疗法(ERT)。ERT似乎要 改善许多老年女性的记忆力。然而，这些研究令人困惑。 有几个因素。此外，黄体酮对老年人认知的影响 女性几乎被忽视了，尽管这一比例在下降 雌激素。许多研究表明，另一种类固醇皮质醇也 在衰老过程中影响认知。总之，这些荷尔蒙的变化 可能有助于解释与年龄相关的认知的大部分个体差异 拒绝。没有研究表明内源性雌激素、黄体酮或 客观认知绝经后妇女皮质醇水平的研究 性能。在这里，雌激素、孕激素和皮质醇的水平将是 在参与另一项纵向研究的健康老年妇女中进行测量 认知力。受试者的认知状态从青春期、 控制水平到轻度痴呆症。拟议的工作将比较内生性 激素水平与同期认知和纵向认知的关系 过去4年的个人资料。接受急救治疗的女性将与 不服用雌激素补充剂的女性。体内荷尔蒙的相互作用 与认知的关系也将被考察。 这项工作将有助于建立与最佳雌激素水平相关的 记忆维护和/或保护免受年龄相关记忆问题的影响 女人。目前规定的口头ERT通常会导致 超生理水平的雌激素，伴随着有害的一面 效果。如此高的水平可能是围绝经期治疗所必需的 症状(例如潮热)，但可能不是用于预防性治疗 与年龄相关的认知衰退。此外，绝经后的妇女患有 由于健康原因，越来越多的人建议完整的子宫服用 黄体酮补充ERT。因此，重要的是要了解 雌激素和其他激素(黄体酮、 皮质醇)影响认知。首席调查员是 制定卵巢类固醇的长期研究计划 衰老的神经生物学，最初的重点是雌激素对 认知力。收集的数据将有助于指导计划中的ERT的设计 健康老年妇女的干预研究，通过确定适当的 雌激素的目标水平(即与良好的认知能力有关)。