VITAMIN D RECEPTOR GENOTYPE AND ALVEOLAR BONE LOSS

描述：本小额资助（R 03）提案中的研究解决了 假设有牙齿的老年男性经历了加速牙槽骨 维生素D受体（VDR）的变异体 先前与全身骨增加相关的基因型 损失 参加牙科纵向研究的300名受试者 将对VA规范老化研究的组成部分进行检查， 信息，如牙槽骨质量和牙齿脱落发生率的变化， 从他们现有的医疗和牙科记录中挑选出来。 生成的新数据 该项目将确定Taq-1中的等位基因变体， 和VDR基因的阿帕-1多态性。 这些信息将被获取 通过来自单核细胞的基因组DNA的PCR-RFLP分析。 各种 将考虑社会人口统计学、行为和营养参数 由于宿主和环境变量可能相互作用， 与基因型有关，并反映在骨骼和牙齿脱落的变化上。

DESCRIPTION: The research in this Small Grant (R03) proposal addresses the hypothesis that dentate elderly men who undergo accelerated alveolar bone loss and tooth loss possess variants of the vitamin D receptor (VDR) genotype which have been previously associated with increased systemic bone loss. Three hundred subjects participating in the Dental Longitudinal Study component of the VA Normative Aging Study will be examined and have relevant information, such as changes in alveolar bone mass and tooth loss incidence, culled from their existing medical and dental records. New data generated by this project will be the determination of allelic variants in the Taq-1 and Apa-1 polymorphisms of the VDR gene. This information will be acquired by PCR-RFLP analysis of genomic DNA from mononuclear cells. A variety of sociodemographic, behavioral and nutritional parameters will be considered in the data analysis since host and environmental variables may interact with the genotype and be reflected by variations in bone and tooth loss.