EXERCISE AND COGNITION IN OLDER ADULTS WITH COPD

慢性阻塞性肺疾病(COPD)是一种严重削弱身体健康的疾病 对身体健康和身体素质有深远负面影响的疾病 生活。已发现慢性阻塞性肺疾病患者在 神经心理功能、心理幸福感和心理社会 功能正常。尽管过去的几项研究发现，改善身体状况 慢性阻塞性肺疾病患者术后耐力与心理功能的关系 运动康复，这些研究没有充分利用对照 组。此外，到目前为止，还没有研究检查锻炼的影响 康复治疗对慢性阻塞性肺疾病患者神经心理功能的影响这个 拟议的三项研究旨在检查两种急性呼吸道感染的影响 和慢性运动对人群神经心理功能指标的影响 慢性阻塞性肺疾病患者。在第一项研究中，105名COPD患者将被 随机分配到三个组之一：锻炼康复 小组、教育和社会支持控制小组或等待名单 对照组。生理功能，神经心理功能， 将对心理健康和心理社会功能进行评估 在为期10周的培训前后使用标准化测试工具 康复计划。第三项研究将利用一个简短的 神经心理学组件检测运动对人的急性影响 80例慢性阻塞性肺疾病患者的神经心理功能比较 久坐不动的健康老年人。据推测，演习 康复将与以下方面的显著收益相关 神经心理功能和心理健康。结果是 初步研究的结果将会对规划和 为慢性阻塞性肺疾病患者实施康复计划，并将阐明 神经心理功能和心理改变的机制 幸福。这项为期一年的跟踪研究将表明 慢性阻塞性肺疾病患者的康复策略及其预测因素 成功的运动康复结果。第三项研究将探索 慢性阻塞性肺疾病患者认知缺陷反映疾病的程度 过程与人类正常衰老的对比。

Chronic obstructive pulmonary disease (COPD) is a severely debilitating illness with a profound negative impact on physical health and quality of life. COPD patients have been found to exhibit impairments in neuropsychological functioning, psychological well-being, and psychosocial functioning. Although several past studies have found improved physical endurance and psychological functioning among COPD patients following exercise rehabilitation, these studies have not utilized adequate control groups. Furthermore, no study to date has examined the effects of exercise rehabilitation on neuropsychological functioning of COPD patients. The proposed three studies are designed to examine the effects of both acute and chronic exercise on indicators of neuropsychological functioning among COPD patients. For the first study, 105 subjects with COPD will be randomly assigned to one of three groups: an exercise rehabilitation group, an education and social support control group, or a waiting list control group. Physiological functioning, neuropsychological functioning, psychological well-being, and psychosocial functioning will be assessed using standardized test instruments before and after a 10-week rehabilitation program. The third study will utilize a brief neuropsychological battery to examine the acute effects of exercise on neuropsychological functioning among 80 COPD patients in comparison to 80 sedentary, healthy older adults. It is hypothesized that exercise rehabilitation will be associated with significant gains in neuropsychological functioning and psychological well-being. The results of the initial study will have practical implications for planning and implementing rehabilitation programs for COPD patients, and will elucidate mechanisms of change in neuropsychological functioning and psychological well-being. The one-year follow-up study will indicate the efficacy of rehabilitation strategies for COPD patients, as well as the predictors of successful exercise rehabilitation outcomes. The third study will explore the extent to which cognitive deficits among COPD patients reflect disease processes versus normal human aging.