NURSE-RUN-HOME EXERCISE REGIMEN FOR HIV-INFECTED PEOPLE

这是一项随机两组重复测量对照的临床试验 评价护士在家操练效果的试验 对18岁及以上艾滋病毒血清阳性男女的干预 CD-4细胞数在200-500/mm3之间时：(1)身体耐力 (耗氧量，(2)受试者对其功能的感知 使用经过验证的量表(疾病影响概况； 医疗结果研究-艾滋病毒健康调查)和每日奶制品报告，以及 (3)免疫状态(CD-4细胞计数和CD-4百分率)。无论是治疗还是治疗 组和对照组将在基线(第0周)和 为了数据的目的，研究小组分配后8、15和19周 收集。这两组人都将接受来自 他们的定期供货商。这两个小组还将每天记录 选定的症状、情绪和锻炼计划，从基线到 学习结束，每周拿起日记。此外， 治疗组将接受一种锻炼方案，其中包括热- 向上运动；或者在Fit-One运动区进行20分钟的锻炼 或步行计划(如果不能使用运动跑道)；以及降温 所有活动都是在护士的监督下进行的，每周三次 十五个星期。 将进行几个层次的分析。第一，双变量分析 将检验协变量和从属变量之间的关系 可变峰值摄氧量，经学生t检验。第二，改变 峰值摄氧量将通过两个样本的t检验来检验。第三，t- 测试统计数据将用于评估测量之间的关联 功能状态、幸福感和干预组状态。 第四，日记中症状天数的平均值为 组间比较采用t检验统计。第五，变数 预测增强免疫功能的假说将在一项 多元回归模型检验交互作用效应。 这项研究之所以重要，有几个原因：1)它建议 前瞻性地研究锻炼对身体耐力的影响， HIV患者的生活质量和免疫状态首次出现 血清阳性的不同样本的受试者，包括相当数量的 对于非裔美国人、女性和静脉注射吸毒者来说，2)这是一种 护士运行的基于家庭的干预，可以通过以下方式轻松完成 生活环境各异、资源有限的个人， 3)生理、心理状态的日常测量分析 来自日记记录将导致对模式的检查 “轻微”症状，因为它们与 干预。

This is a randomized two-group repeated measures controlled clinical trial to evaluate the effects of a nurse-run home-based exercise intervention for HIV seropositive men and women 18 years of age and older with CD-4 cell counts between 200 - 500/mm3 on: (1) physical endurance (oxygen consumption, (2) subjects perceptions of both their functional status and well-being using validated scales (Sickness Impact Profile; Medical Outcomes Study-HIV Health Survey) and daily dairy reports, and (3) immune status (CD-4 cell count and CD-4 percent). Both the treatment group and the control group will be tested at baseline (week 0) and at 8, 15 and 19 weeks after study group assignment for the purposes of data collection. Both groups will receive usual medical and nursing care from their regular providers. Both groups will also keep daily diaries of selected symptoms, mood, and exercise routines from baseline through study exit with weekly pick-ups of the diaries. In addition, the treatment group will receive an exercise regimen which will include warm- up movements; either a 20 minute work-out on the Fit-One exercise tract or a walking program (if unable to use the exercise track); and cool-down movements, all done under nursing supervision three times a week for fifteen weeks. Several levels of analyses will be conducted. First, bivariate analysis will examine relationships between the covariates and the dependent variable, peak oxygen uptake, by Student's t-test. Second, change in peak oxygen uptake will be examined by a two-sample t-test. Third, t- test statistics will be used to assess the association between measures of functional status and well-being and intervention group status. Fourth, the means of numbers of symptom-days from the diary will be compared between groups by t-test statistics. Fifth, variables hypothesized to predict enhanced immune function will be examined in a multivariate regression model to examine interaction effects. This study is important for several reasons: 1) it proposes to prospectively study the effects of exercise on physical endurance, quality of life, and immune status for the first time in an HIV seropositive diverse sample os subjects including a substantial number of African-Americans, women, and intravenous drug users, 2) it is a nurse-run home-based intervention that can be readily completed by individuals in a variety of living situations and with limited resources, and 3) analysis of daily measures of physiologic and psychologic status from diary recordings will result in an examination of patterns of "minor" symptoms for their association with the effects of the intervention.