NURSE-RUN-HOME EXERCISE REGIMEN FOR HIV-INFECTED PEOPLE

这是一个随机两组重复测量对照的临床研究。 一项评估护士家庭运动效果的试验 对18岁及以上艾滋病毒血清反应阳性男女的干预 CD-4细胞计数在200 - 500/mm3之间：（1）身体耐力 （氧消耗量，（2）受试者对他们的功能的感知 使用经验证的量表（疾病影响概况; 医学结果研究-艾滋病毒健康调查）和每日日记报告，以及 (3)免疫状态（CD-4细胞计数和CD-4百分比）。 两个治疗 组和对照组将在基线（第0周）和 出于数据目的，研究组分配后8、15和19周 收藏. 两组患者将接受常规的医疗和护理， 他们的常规供应商 两个小组还将每天记录 从基线到基线的选定症状、情绪和锻炼习惯 研究退出，每周收集日记。 此外该 治疗组将接受运动方案，其中包括温暖， 向上运动;要么在Fit-One运动道上锻炼20分钟 或步行计划（如果无法使用运动轨道）;和冷却 运动，所有这些都在护理监督下进行，每周三次， 十五周。 将进行几个层次的分析。 第一，双变量分析 将检查协变量和因变量之间的关系 变量，峰值摄氧量，通过Student t检验。 第二，改变 峰值氧摄取将通过双样本t检验来检验。 第三，T- 检验统计量将用于评估测量之间的关联 功能状态和幸福感以及干预组的状态。 第四，从日记中获得的天数的平均值将是 组间比较采用t检验统计。 第五，变量 假设预测增强的免疫功能将在一个 多元回归模型，以检查相互作用的影响。 这项研究之所以重要，有几个原因：1）它提出， 前瞻性研究运动对身体耐力的影响， 生活质量和免疫状况首次在艾滋病毒 包括大量受试者的血清阳性多样化样本 非裔美国人，妇女和静脉注射毒品使用者，2）这是一个 护士运行的家庭干预，可以很容易地完成 生活状况各异且资源有限的个人， 3）分析日常生理和心理状态的测量值 从日记记录将导致检查的模式， "轻微"症状与 干预

This is a randomized two-group repeated measures controlled clinical trial to evaluate the effects of a nurse-run home-based exercise intervention for HIV seropositive men and women 18 years of age and older with CD-4 cell counts between 200 - 500/mm3 on: (1) physical endurance (oxygen consumption, (2) subjects perceptions of both their functional status and well-being using validated scales (Sickness Impact Profile; Medical Outcomes Study-HIV Health Survey) and daily dairy reports, and (3) immune status (CD-4 cell count and CD-4 percent). Both the treatment group and the control group will be tested at baseline (week 0) and at 8, 15 and 19 weeks after study group assignment for the purposes of data collection. Both groups will receive usual medical and nursing care from their regular providers. Both groups will also keep daily diaries of selected symptoms, mood, and exercise routines from baseline through study exit with weekly pick-ups of the diaries. In addition, the treatment group will receive an exercise regimen which will include warm- up movements; either a 20 minute work-out on the Fit-One exercise tract or a walking program (if unable to use the exercise track); and cool-down movements, all done under nursing supervision three times a week for fifteen weeks. Several levels of analyses will be conducted. First, bivariate analysis will examine relationships between the covariates and the dependent variable, peak oxygen uptake, by Student's t-test. Second, change in peak oxygen uptake will be examined by a two-sample t-test. Third, t- test statistics will be used to assess the association between measures of functional status and well-being and intervention group status. Fourth, the means of numbers of symptom-days from the diary will be compared between groups by t-test statistics. Fifth, variables hypothesized to predict enhanced immune function will be examined in a multivariate regression model to examine interaction effects. This study is important for several reasons: 1) it proposes to prospectively study the effects of exercise on physical endurance, quality of life, and immune status for the first time in an HIV seropositive diverse sample os subjects including a substantial number of African-Americans, women, and intravenous drug users, 2) it is a nurse-run home-based intervention that can be readily completed by individuals in a variety of living situations and with limited resources, and 3) analysis of daily measures of physiologic and psychologic status from diary recordings will result in an examination of patterns of "minor" symptoms for their association with the effects of the intervention.