AFFECTIVE DISORDERS--AN EXPLORATION OF LONG-TERM COURSE

情感障碍——长期历程的探索

• 批准号: 2250566
• 负责人: William Henry Coryell
• 金额: $ 12.04万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2250566
• 关键词: anxiety disorders; bipolar depression; computer data analysis; data collection methodology /evaluation; diagnosis quality /standard; disease /disorder classification; disease /disorder proneness /risk; human data; longitudinal human study; major depression; mental disorder diagnosis; mood disorders; personality tests; prognosis; psychosis; relapse /recurrence; schizophrenia; social adjustment; statistics /biometry

Between 1978 and 1981, the NIMH Collaborative Depression Study conducted thorough baseline evaluations of 955 probands with major affective disorder. These subjects have now been followed at semiannual and annual intervals to ten years with a retention rate of 70.1% of those still living. The study also evaluated a large sample (N=2,616) of nonclinical subjects (relatives, controls and spouses) at baseline and again six years later. A high-intensity substudy has shown that the occurrence and timing of major depression disorder episodes among the members of this sample can be validly compared to corresponding measures in the proband sample. The size, scope, intensity, and duration of these follow-up efforts have thus generated a unique data set with very broad potential. Previous CDS publications have been based on shorter follow-up periods and have emphasized the course of index episodes, the time to subsequent clinical events, and the long-range prognostic qualities of baseline measures. The investigators now propose to fully explore the ten-year follow-up data with a shift in emphasis to the timing and phenomenology of prospectively observed episodes, to overall trends across repeated observations, to direct comparisons between probands and nonclinical subjects, and to the application of new statistical means toward these ends. The first three of these general aims will circumvent important selection biases which are inescapable for essentially all other follow-up studies. The last of these aims will be abetted through an affiliation with the biostatistics division in the Department of Preventive Medicine. The investigators intend an emphasis on nosological questions, a longstanding focus for researchers at the Iowa center.

在1978年至1981年期间，NIMH合作抑郁症研究进行了 对955名主要情感障碍先证者进行了全面的基线评估， disorder. 这些受试者现在每半年和每年都被跟踪一次。 间隔至10年，留存率为70.1 living. 该研究还评估了一个大样本（N= 2，616）的非临床 受试者（亲属、对照组和配偶）在基线时， 年后 一项高强度的子研究表明， 本研究的成员中抑郁症发作的时间 样本可以有效地与先证者的相应测量进行比较 sample. 这些随访的规模、范围、强度和持续时间 因此，经过努力，产生了一套具有非常广泛潜力的独特数据集。 之前的CDS出版物基于较短的随访期 并强调了指数发作的过程， 临床事件和基线的长期预后质量 措施 调查人员现在建议全面探索十年来 随访数据，重点转向时间和现象学 前瞻性观察到的发作，与重复发作的总体趋势 观察，以直接比较先证者和非临床 主题，并对这些新的统计手段的应用 形接头. 前三个总目标将绕过重要的 选择偏见，这是不可避免的，基本上所有其他 后续研究。 这些目标中的最后一个将通过 与系生物统计部门的联系 预防医学。 研究人员打算强调疾病分类学 问题，这是爱荷华州中心研究人员长期关注的焦点。