FEASIBILITY STUDY--ULTRASONIC MEASUREMENT OF ARTICULAR CARTILAGE

可行性研究--关节软骨的超声测量

• 批准号: 3727933
• 负责人: KRIS A DINES
• 金额: --
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3727933
• 关键词: articular cartilage; computer program /software; diagnosis design /evaluation; diagnosis quality /standard; dogs; human subject; human tissue; image processing; mathematical model; osteoarthritis; pathologic process

The studies proposed herein investigate the feasibility of using high- frequency ultrasonic imaging to characterize and monitor the progressive articular cartilage degeneration associated with osteoarthritis. The approach provides a comprehensive investigation of the relationships between ultrasonic signal descriptors and the geometrical and biochemical properties of cartilage. Specific aims of the study are designed to examine ultrasonic attenuation, thickness, surface scattering, and internal scattering; and to correlate these descriptors with the cartilage water content, uronic acid concentration, thickness, and histologic appearance. Data processing algorithms will be developed to extract the ultrasonic descriptors from digitized A-mode signals and B-mode images obtained at frequencies of 25 MHz and 50 MHz. The relationship between ultrasonic measurements and histologic and biochemical properties will be examined by standard correlation and linear regression analysis and a nonparametric approach utilizing statistical pattern recognition. In vitro experiments with canine and human articular cartilage will examine the practically attainable tissue characterization capability, complexity of implementation, and overall feasibility of the approach. If the approach exhibits discrimination capabilities commensurate with clinical needs, a follow-up proposal will be devoted to the development of an arthrosonographic imaging probe for in vivo application.

本文提出的研究调查使用高- 频率超声成像来表征和监测渐进性 与骨关节炎相关的关节软骨退化。 的 方法提供了一个全面的调查的关系 超声信号描述符与几何和生物化学 软骨的特性。 研究的具体目的是检查超声衰减， 厚度、表面散射和内部散射;以及 这些描述符与软骨水含量、糖醛酸 浓度、厚度和组织学外观。 数据处理 算法将被开发，以提取超声描述符， 数字化的A模式信号和B模式图像，在25 MHz和50 MHz。 超声波测量与 组织学和生物化学特性将通过标准 相关和线性回归分析以及非参数方法 利用统计模式识别。 用狗和人类关节软骨进行的体外实验将检查 实际上可获得的组织表征能力、复杂性 执行情况和方法的总体可行性。 如果 方法显示出与临床相匹配的辨别能力 需要，将提出一项后续建议， 用于体内应用的关节超声成像探头。