Mechanisms of Hedgehog Signaling in Small Cell Lung Cancer

小细胞肺癌中 Hedgehog 信号传导机制

• 批准号: nhmrc : 1048669
• 负责人: A/Pr Vinod Ganju
• 金额: $ 29.31万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanisms-hedgehog-signaling-lung-cancer/112029
• 关键词: Mechanisms; Hedgehog; Signaling; Small; Cell

Some types of lung are very sensitive to chemotherapy, however they frequently relapse, at which time they become resistant to this form of treatment. This project investigates how embryonic signaling pathways, that normally function to regulate organ formation in development, are activated and promote tumor regrowth following chemotherapy for lung cancer.

有些类型的肺对化疗非常敏感，但它们经常复发，这时它们就会对这种治疗产生抵抗力。这个项目调查了在肺癌化疗后，胚胎信号通路是如何被激活并促进肿瘤再生长的，这些信号通路通常在发育过程中调节器官形成。