Risk Factors for Breast Cancer in Orange County, Florida

描述（由申请人提供）以前的流行病学和实验证据表明，抗抑郁药物和乳腺癌风险之间可能存在关联，但存在一些方法上的缺陷。这项研究的主要目的是调查这种关联，同时解决以前研究中的缺陷。主要假设是抗抑郁药会增加患乳腺癌的风险。这是一项基于人群的病例对照研究。从佛罗里达州癌症登记处选择的55-74岁病例将是400例乳腺癌病例（ICD-9代码174），诊断时间为1997年1月1日至2000年12月31日，或数据完整的2001年最近一个月。控制将是400名女性橙子县居民，并将从佛罗里达州驾驶执照文件中选择。将其与人种和年龄（间隔5年）病例进行频率匹配。将由经过培训的访谈者进行电话访谈，使用结构化问卷和诊断访谈时间表（DIS）收集有关既往使用抗抑郁药、抑郁症病史和许多潜在混杂因素的数据。将通过非条件logistic回归分析对数据进行分析。将报告与抗抑郁药使用相关的乳腺癌风险的比值比（OR）和95% CI，并将根据年龄、种族、乳腺癌家族史、酒精和其他潜在混杂因素进行调整。其他分析将包括按抑郁状态分层的分析、剂量反应分析和抗抑郁药与以下各项之间的相互作用分析：抑郁、乳腺癌家族史、良性乳腺疾病史和生殖史。研究结果将在未来使用抗抑郁药的影响方面进行讨论。

DESCRIPTION (provided by applicant)Previous epidemiologic and experimental evidence suggesting a possible association between antidepressant drugs and the risk of breast cancer have several methodological weaknesses. The broad objective of this study is to investigate this association while addressing the flaws in previous studies. The primary hypothesis is that antidepressants increase the risk of breast cancer. This is a population-based case-control study. The 55-74 year-old cases to be selected from the Florida State Cancer Registry will be 400 breast cancer cases (ICD-9 code 174), diagnosed between 1/1/97 and 12/31/00, or the latest month in 2001 for which data are complete. The controls will be 400 female Orange County residents, and will be selected from Florida State Drivers' License files. They will be frequency-matched with cases on race and age (5-year intervals). Telephone interviews will be conducted by trained interviewers to collect data on past use of antidepressants, depression history and many potential confounders, using a Structured Questionnaire and the Diagnostic Interview Schedule (DIS). The data will be analyzed by means of unconditional logistic regression analysis. Odds ratios (ORs) and 95% CIs will be reported for breast cancer risk associated with antidepressant use, and will be adjusted for age, race, family history of breast cancer, alcohol, and other potential confounders. Additional analyses will include analysis stratified by depression status, dose-response analysis, and analysis for interactions between antidepressants and each of: depression, family history of breast cancer, history of benign breast disease and reproductive history. The results will be discussed in terms of implications for future use of antidepressants.