A Cohort Study of Active and Passive Smoking in Korea

韩国主动吸烟和被动吸烟的队列研究

• 批准号: 6622514
• 负责人: JONATHAN M SAMET
• 金额: $ 5.86万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-19 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6622514
• 关键词: Asia; adolescence (12-20); adult human (21+); cancer risk; data collection; disease /disorder proneness /risk; epidemiology; health insurance; hospital utilization; human data; human mortality; information systems; passive smoking; questionnaires; smoking

Although 50 years of research findings have causally linked active and passive smoking to cancer and other diseases, further epidemiologic research on the risks of tobacco smoking is still needed. One specific need is for studies in countries other than the developed, western countries where the majority studies have been conducted to date. Most of the world's smokers live outside of the western countries, primarily in Asia where a majority of males are smokers in many countries. Background disease rats and distributions of lifestyle risk factors are notably distinct in these populations, particularly in comparison with populations of previously studied western males. The majority of women, largely non-smokers, and children in Asian countries are exposed to environmental tobacco smoke (ETS). This small grant application requests support to establish a cohort study of active and passive smoking and risk for cancer and other diseases among persons receiving health insurance coverage through the Korean Medical Insurance Corporation (KMIC). The KMIC provides coverage to civil service workers, teachers, and their dependents in the Republic of Korea (South Korea). The total population insured by the KMIC is substantial, accounting for 11% of the country's 43 million residents in 1990. The insured then included approximately 1.2 million workers and an additional 3.4 dependents. A cohort study will be developed using the database of the KMIC. Risk factor information is collected in biennial medical examinations, which are required for the insured workers and are voluntarily completed by dependents. The data collected in the biennial examinations covering smoking and other lifestyle risk for disease and findings from routine laboratory work are also available. Outcomes are tracked through the hospital record system and also by mortality matches. Family members of the insured can be identified through record linkage using the unique identification number of the insured. In an effort to advance understanding of smoking and cancer and other diseases in Asian countries, as well as among Asian Americans, investigators at the Yonsei University and the Johns Hopkins University School of Hygiene and Public Health plan to collaborate in developing and then using this epidemiologic resource to carry out a major program of research on the risks of active and passive smoking in Korea. The Yonsei University has access to the KMIC cohort and already has shown its potential in several reports on cancer and cardiovascular disease. The Johns Hopkins group adds expertise in cohort studies and smoking. This application requests support to establish a comprehensive database in support of the cohort study and to carry out analyses on active and passive smoker and cancer. During the two years of support requested in this small grant application, data will be abstracted from medical records on key exposure variables from exams carried out in 1992 and 1993, providing lifestyle and laboratory data for cohort expected to number approximately 1.6 million adults. Mortality will be tracked from 1992-2003 and inpatient encounters, coded by diagnosis, will be identified for 1998-2003. To demonstrate the potential of the study, an investigation will be carried out on active and passive smoking and lung cancer risk. We intend to set data collection in place to maintain and extend this cohort. The large size of this cohort and the unusually strong possibility for data linkage makes the KMIC population a unique and cost effective study opportunity. This cohort study would have the potential to generate powerful evidence to describe the risk of smoking in a population with distinct background disease rates and distribution of lifestyle risk factors relative to western populations previously studied.

虽然50年的研究结果表明，主动吸烟和被动吸烟与癌症和其他疾病有因果关系，但仍需要对吸烟的风险进行进一步的流行病学研究。一个具体的需求是在发达国家以外的国家进行研究，西方国家迄今为止已经进行了大多数研究。世界上大多数吸烟者生活在西方国家以外，主要是在亚洲，在许多国家，大多数男性吸烟者。背景疾病大鼠和生活方式的危险因素的分布是显着不同的，在这些人群中，特别是在与以前研究的西方男性人口。亚洲国家的大多数妇女（主要是非吸烟者）和儿童暴露于环境烟草烟雾（ETS）。这份小额赠款申请要求提供支助，以便在通过韩国医疗保险公司接受健康保险的人中开展一项关于主动吸烟和被动吸烟与癌症和其他疾病风险的队列研究。KMIC为大韩民国（韩国）的公务员、教师及其家属提供保险。KMIC保险的总人口数量很大，1990年占全国4，300万居民的11%。受保人包括大约120万工人和另外340万受抚养人。将使用KMIC数据库开展队列研究。危险因素信息是在每两年一次的体检中收集的，这是对投保工人的要求，由家属自愿完成。每两年进行一次的检查所收集的数据，包括吸烟和其他生活方式对疾病的风险，以及常规实验室工作的结果。结果通过医院记录系统和死亡率匹配进行跟踪。被保险人的家庭成员可以通过使用被保险人的唯一识别号码的记录链接来识别。为了增进亚洲国家和亚裔美国人对吸烟、癌症和其他疾病的了解，延世大学和约翰霍普金斯大学卫生与公共卫生学院的研究人员计划合作开发并利用这一流行病学资源，在韩国开展一项关于主动吸烟和被动吸烟风险的重大研究计划。延世大学已经进入KMIC队列，并在几份关于癌症和心血管疾病的报告中显示了其潜力。约翰霍普金斯集团增加了队列研究和吸烟方面的专业知识。该申请要求支持建立一个综合数据库，以支持队列研究，并对主动和被动吸烟者与癌症进行分析。在这一小额赠款申请所要求的两年支助期间，将从1992年和1993年进行的检查的关键暴露变量的医疗记录中提取数据，为预计约160万成年人的队列提供生活方式和实验室数据。将跟踪1992-2003年的死亡率，并确定1998-2003年的住院病例，按诊断编码。为了证明这项研究的潜力，将对主动吸烟和被动吸烟与肺癌风险进行调查。我们打算收集数据，以维持和扩大这一队列。该队列的大规模和异常强的数据关联可能性使KMIC人群成为一个独特且具有成本效益的研究机会。这项队列研究将有可能产生强有力的证据来描述吸烟的风险在一个人口与不同的背景疾病率和分布的生活方式危险因素相对于西方人口以前研究。

项目成果

Fasting glucose level and the risk of incident atherosclerotic cardiovascular diseases.

• DOI: 10.2337/dc12-1577
• 发表时间: 2013-07
• 期刊: Diabetes care
• 影响因子: 16.2
• 作者: Park C;Guallar E;Linton JA;Lee DC;Jang Y;Son DK;Han EJ;Baek SJ;Yun YD;Jee SH;Samet JM
• 通讯作者: Samet JM