Conservation and Sustainable Use of Biodiversity in PNG

巴布亚新几内亚生物多样性的保护和可持续利用

• 批准号: 6720412
• 负责人: Louis R Barrows
• 金额: $ 68.35万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-25 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6720412
• 关键词: Papua New Guinea; biological products; classification; cooperative study; drug discovery /isolation; ecology; marine biology; medicinal plants; plant extracts; socioeconomics; soil microbiology

DESCRIPTION (provided by applicant): The overarching goals of this ICBG are to improve human health and well being through an integrated set of programs dedicated to the assessment, conservation, and rational utilization of the flora and fauna of Papua New Guinea (PNG). With more than 34 million hectares of closed tropical forests, PNG ranks 9th among the most forested tropical countries of the world. Understanding of the full range of biological resources resident in PNG is essential for their management and the preservation of species critical to indigenous cultures, and for the development of strategies for sustainable resource use. It is a central hypothesis of this work that effective new therapeutics can be derived from the natural products of PNG flora and fauna. Such therapeutics, either as Western medicines or marketed as traditional phytomedicines, can provide needed revenue to local stakeholders and responsible PNG institutions. This income would provide alterative, non-timber, economic value to PNG forests and reefs and an incentive for the preservation of biological diversity. The participants in this consortium include: 1) the University of Utah, which will participate in anti-TB, anti-HIV, anti-malaria, anticancer, and neurotropic drug discovery with Brigham Young University and the University of Miami, natural products isolation and structure determination, and grant administration; 2) the University of Papua New Guinea, which will participate in plant inventory and collection with the National Forest Research Institute, ethnomedicinal plant collection, extract preparation and screening, natural product economic evaluation, the development of intellectual property rights legislation with PNG BioNET and the Department of Environment and Conservation, outreach and education with the NGO Conservation Melanesia, and marine reef conservation and marine invertebrate inventory with The Nature Conservancy; 3) the Smithsonian Institution, which, with the Natural History Museum, London, will execute analysis of PNG flora and fauna collections that have been exported from PNG, and data repatriation; 4) Wyeth Research will isolate actinomycetes, fungi and additional microbes from unique marine and terrestrial niches, and analyze these microbial cultures, and the plant extracts prepared above, for pharmacologic potential in their disease focus areas.

描述（由申请人提供）：该 ICBG 的总体目标是通过一套致力于评估、保护和合理利用巴布亚新几内亚 (PNG) 动植物群的综合计划来改善人类健康和福祉。巴布亚新几内亚拥有超过 3400 万公顷的热带雨林，在世界上森林覆盖率最高的热带国家中排名第九。了解巴布亚新几内亚的各种生物资源对于管理和保护对土著文化至关重要的物种以及制定可持续资源利用战略至关重要。这项工作的一个中心假设是，有效的新疗法可以从巴布亚新几内亚动植物群的天然产物中衍生出来。此类疗法，无论是作为西药还是作为传统植物药销售，都可以为当地利益相关者和负责任的巴布亚新几内亚机构提供所需的收入。这笔收入将为巴布亚新几内亚森林和珊瑚礁提供替代性的、非木材的经济价值，并激励保护生物多样性。该联盟的参与者包括： 1) 犹他大学，将与杨百翰大学和迈阿密大学一起参与抗结核、抗艾滋病、抗疟疾、抗癌和神经药物发现、天然产物分离和结构测定以及拨款管理； 2) 巴布亚新几内亚大学将与国家森林研究所一起参与植物清查和收集、民族药用植物收集、提取物制备和筛选、天然产品经济评估、与巴布亚新几内亚生物网和环境与保护部一起制定知识产权立法、与非政府组织美拉尼西亚保护组织进行外展和教育、与大自然保护协会一起参与海洋珊瑚礁保护和海洋无脊椎动物清查； 3) 史密森学会将与伦敦自然历史博物馆合作，对从巴布亚新几内亚出口的巴布亚新几内亚动植物群藏品进行分析，并将数据传回； 4) 惠氏研究中心将从独特的海洋和陆地生态位中分离放线菌、真菌和其他微生物，并分析这些微生物培养物以及上述制备的植物提取物，以了解其在疾病重点领域的药理学潜力。