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DELIVERY OF ANTIOXIDANT ENZYMES & GENES TO NEONATAL LUNG

DELIVERY OF ANTIOXIDANT ENZYMES & GENES TO NEONATAL LUNG
抗氧化酶的输送
批准号：
6612819
负责人：
Jonathan M. Davis
金额：
$46.56万
依托单位：
NYU WINTHROP HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-07-01 至 2005-06-30
来源：
https://reporter.nih.gov/project-details/6612819
关键词：
Adenoviridae antioxidants bronchopulmonary dysplasia cytomegalovirus gene therapy genetic promoter element genetically modified animals hyperoxia laboratory mouse nonhuman therapy evaluation premature infant animal sheep superoxide dismutase tissue /cell culture transfection /expression vector

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DESCRIPTION: (Adapted from the Investigator's Abstract): Aim 1 will determine the optimal combination of supplemental AOE required to protect cells from hyperoxia. This will be done using a pulmonary epithelial cell culture system exposed to hyperoxia. Aim 2 is to improve the distribution and uptake of AOE in the lung. Stabilized suspensions will be tested in cell culture and in mice exposed to hyperoxia for their effects on cell viability, virus infectivity, multiple gene delivery and expression, and degree of injury. Aim 3 will use viral constructs containing AOE genes under the control of the human SP-B promoter (to target Type II or Clara cells) or the CMV promoter. Aim 4 is to compare the effects of PFC-protein or adenoviral-associated AOE suspensions on normal or injured, preterm or term lamb lungs, using assays for levels and duration of transgene expression.
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