Net Lifetime Health Effects of Alcohol Use & Abuse

饮酒对终生健康的净影响

• 批准号: 6578356
• 负责人: R. Curtis Ellison
• 金额: $ 71.5万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-16 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6578356
• 关键词: accidents; adult human (21+); age difference; alcoholic beverage consumption; alcoholism /alcohol abuse; alcoholism /alcohol abuse information system; bone fracture; cardiovascular disorder epidemiology; caucasian American; clinical research; cognition; disease /disorder proneness /risk; epidemiology; epilepsy; functional ability; human data; human mortality; liver disorder; longitudinal human study; mental health epidemiology; neoplasm /cancer; stroke; syncope; technology /technique development

DESCRIPTION (provided by applicant): While the association of alcohol consumption and the risk of many specific disease entities has been investigated in great detail, there are serious deficiencies in knowing the overall relation of alcohol consumption to health and disease throughout the adult lifespan. Given that alcohol has both detrimental and possibly beneficial effects, it is important to know its net effects on the risk of death and of a number of diseases and health conditions that may relate, either positively or inversely, to its use or abuse. We propose to use data collected over 27-55 years among the 10,000+ subjects in the population-based Framingham Study to relate the amount and pattern of alcohol consumption over a large part of their adult lifetime to two of the most important aspects of life: (a) survival (total mortality) and (b) indices of cognitive function. We will also relate alcohol consumption to indices of disability and to a number of other diseases and conditions affected by alcohol intake, including liver disease, accidents, specific cancers, hypertension, coronary disease, stroke, other cardiovascular diseases, seizures, syncope, falls and fractures. The Framingham Study is unique in being able to provide repeated measurements of the amount and pattern of alcohol use and measures of health and disease over what is essentially the entire adult lifespan (until old age for most and until death for more than one half of subjects). The proposed study would carry out an extensive review of health information collected at every encounter with each subject throughout follow up, classify each subject at each encounter according to alcohol consumption (amount and pattern of drinking), identify those with alcohol use disorders, prepare a complete dataset of diseases and causes of death (currently complete only for cardiovascular disease and cancer), and then examine the relation of alcohol use and alcohol use disorders to total mortality (overall and by age strata) and to indices of cognitive function assessed repeatedly over time. The net effects of varying amounts and patterns of drinking would be related to outcomes at different ages. The study will produce a unique dataset and will provide information that should improve our knowledge of the net effects of alcohol throughout adult life.

描述（由申请人提供）：虽然详细研究了饮酒和许多特定疾病实体的风险，但在整个成人寿命中，饮酒与健康和疾病的总体关系的总体关系存在严重的缺陷。鉴于酒精既有害，也可能是有益的影响，因此重要的是要了解其对死亡风险以及许多可能与其使用或滥用相关的疾病和健康状况的净影响。我们建议在基于人群的Framingham研究中使用10,000多名受试者中收集的数据超过27 - 55年，以将其大部分成人寿命的饮酒量和模式与生活的两个最重要方面相关联：（a）生存（a）生存（总死亡率）和（b）认知功能的指数。我们还将将酒精消耗与残疾指数以及受酒精摄入影响的许多其他疾病和疾病有关，包括肝病，事故，特定癌症，高血压，冠状动脉疾病，中风，其他心血管疾病，癫痫发作，癫痫发作，癫痫发作，晕厥，晕厥，跌倒和裂缝。 Framingham的研究在能够重复测量酒精使用量和模式的重复测量以及对整个成人寿命（大多数年龄段）上的重复测量和衡量的量很独特（直到大多数人的年龄，直到死亡超过一半的受试者）。拟议的研究将对每次接触的每一次接触时收集的健康信息进行广泛审查，根据酒精消费（饮酒量和饮酒量）在每次相遇中对每个受试者进行分类，确定患有酒精使用障碍的人，准备疾病的完整数据，准备死亡数据，目前仅根据饮酒和饮酒的疾病和饮酒，以确定疾病的疾病和整体疾病，然后检查整体疾病，然后检查疾病的疾病，并进行了整体疾病的使用率，并进行了饮酒的关系。随着时间的流逝，认知功能反复评估。饮酒量和模式的净影响与不同年龄的结果有关。这项研究将产生独特的数据集，并将提供信息，以提高我们对在成年生活中酒精净影响的了解。