CRF and Personality Disorder: Behavioral Correlates

CRF 和人格障碍：行为相关性

• 批准号: 6676817
• 负责人: Royce Lee
• 金额: $ 7.63万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6676817
• 关键词: adrenocorticotropic hormone; behavioral /social science research tag; cerebrospinal fluid; child behavior; clinical research; corticotropin releasing factor; cortisol; hormone regulation /control mechanism; human subject; hypothalamic pituitary adrenal axis; personality disorders; posttraumatic stress disorder; psychological shock; psychological stressor; questionnaires

DESCRIPTION (provided by applicant): The specifc aim of the proposed project is to test the hypothesis that history of childhood trauma as measured by the Childhood Trauma Questionnaire (CTQ) is associated with elevated CSF corticotropinreleasing factor (CRF) as measured by basal assessment of CSF CRF levels, and associated with elevated ACTH responses to oCRF Challenge in adult personality disorder (i.e. borderline personality disorder) subjects. This study will compare CSF CRF and ACTH response to oCRF in 10 personality disorder subjects with high scores on the Childhood Trauma Questionnaire with 10 personality disorder subjects with low scores on the Childhood Trauma Questionnaire. Personality disorder subjects will be otherwise healthy, without comorbid depression, posttraumatic stress disorder, or substance abuse. The 20 personality disorder subjects will be compared with 10 normal healthy controls with respect to CSF CRF level. A relationship between HPA axis function and childhood maltreatment has been previously described in adults with PTSD or Major depression and in primate and non-primate animal models of emotional/physical neglect. In this study, we seek to: a) replicate the history of childhood trauma/CRF relationship in PD subjects using basal CSF sampling of CRF; b) extend the findings of our previous study by examining both female and male personality disorder subjects; c) extend the findings by examing ACTH response to oCRF Challenge; d) compare CSF CRF and ACTH response to oCRF challenge to healthy normal controls. PD subjects will be prospectively identified as having been exposed to high amounts of childhood maltreatment or low amounts using scores from the Childhood Trauma Questionnaire (CTQ).20 male and female personality disorder subjects stratified into high vs. low CTQ score responders and 10 healthy normal controls will be admitted to our General Clinical Research Center for both lumbar puncture for CSF CRF and oCRF challenge.If this study is able to establish a relationship between history of childhood trauma and altered CSF CRF level and CRF responsivity (elevated ACTH response to oCRF challenge) in personality disordered subjects, this would allow for further work exploring the relationship between childhood trauma, HPA axis function, and stress reactivity in personality disorder.

描述（申请人提供）：该项目的具体目的是检验以下假设：通过儿童期创伤问卷（CTQ）测量的儿童期创伤史与通过CSF促肾上腺皮质激素释放因子（CRF）水平的基础评估测量的CSF CRF升高相关，并且与成人人格障碍（即边缘型人格障碍）受试者中对oCRF激发的升高的ACTH应答相关。本研究将比较10例儿童期创伤问卷得分高的人格障碍受试者和10例儿童期创伤问卷得分低的人格障碍受试者的CSF CRF和ACTH对oCRF的反应。人格障碍受试者在其他方面是健康的，没有共病抑郁症、创伤后应激障碍或药物滥用。将20例人格障碍受试者与10例正常健康对照者的CSF CRF水平进行比较。HPA轴功能与儿童期虐待之间的关系先前已在患有PTSD或重度抑郁症的成年人以及情感/身体忽视的灵长类和非灵长类动物模型中描述。在本研究中，我们试图：a）使用CRF的基础CSF采样复制PD受试者的儿童创伤/CRF关系史; B）通过检查女性和男性人格障碍受试者来扩展我们先前研究的结果; c）通过检查ACTH对oCRF激发的反应来扩展研究结果; d）将CSF CRF和ACTH对oCRF激发的反应与健康正常对照进行比较。PD受试者将使用儿童期创伤问卷（CTQ）的评分，前瞻性地确定为儿童期遭受过大量虐待或少量虐待将20名男性和女性人格障碍受试者分为高CTQ评分应答者和低CTQ评分应答者，以及10名健康正常对照者，将被接纳到我们的综合临床研究中心进行腰椎穿刺以进行CSF CRF和oCRF激发。在人格障碍受试者中，能够建立童年创伤史与改变的CSF CRF水平和CRF反应性（升高的ACTH对oCRF激发的反应）之间的关系，这将允许进一步的工作探索童年创伤、HPA轴功能和人格障碍中的应激反应性之间的关系。

项目成果

The neuroendocrinology of childhood trauma in personality disorder.

人格障碍儿童创伤的神经内分泌学。

• DOI: 10.1016/j.psyneuen.2011.05.006
• 发表时间: 2012
• 期刊: Psychoneuroendocrinology
• 影响因子: 3.7
• 作者: Lee,RoyceJ;Hempel,Jessica;Tenharmsel,Aaron;Liu,Tianmin;Mathé,AleksanderA;Klock,Alan
• 通讯作者: Klock,Alan