CRF AND PERSONALITY

CRF 与个性

• 批准号: 7604759
• 负责人: Royce Lee
• 金额: $ 1.21万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604759
• 关键词: Adult; Affect; Animal Model; Behavioral; Brain; Childhood; Computer Retrieval of Information on Scientific Projects Database; Corticotropin-Releasing Hormone; Data; Early-life trauma; Funding; Grant; Hormones; Human; Hypothalamic structure; Institution; Measures; Monkeys; Personality; Personality Disorders; Psychopathology; Questionnaires; Rattus; Recording of previous events; Research; Research Personnel; Resources; Risk Factors; Source; Stress; United States National Institutes of Health; Up-Regulation; pediatric trauma

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Introduction: Childhood trauma is a risk factor for many psychopathologies, including personality disorder. Although the mechanism in humans by which childhood trauma affects the brain to cause personality disorder is unknown, animal models exist which implicate the hypothalamic-pitutary axis. Animal models in rats and monkeys find evidence that early life trauma causes an upregulation in the expression of brain corticotrophin-releasing factor along with increased behavioral stress reactivity. Pilot data that has already been collected is consistent with a direct realtionship between history of childhood trauma and adult CSF corticotropin-releasing factor levels. The specific aim of the proposed project is to investigate the realtionship between history of childhood trauma as measured by the Childhood Truama Questionnaire and stress hormone alterations in adult, personality disordered subjects.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 简介：童年创伤是许多精神病理学的危险因素，包括人格障碍。 尽管人类童年创伤影响大脑导致人格障碍的机制尚不清楚，但存在涉及下丘脑-垂体轴的动物模型。 大鼠和猴子的动物模型发现证据表明，早年创伤导致大脑促肾上腺皮质激素释放因子表达上调，同时行为应激反应性增加。 已经收集的试点数据与儿童创伤史和成人脑脊液促肾上腺皮质激素释放因子水平之间的直接关系一致。 该项目的具体目的是调查通过《童年创伤问卷》测量的童年创伤史与成年人格障碍受试者的应激激素变化之间的关系。