Optical Mapping of Nonmelanoma Skin Cancers

非黑色素瘤皮肤癌的光学测绘

• 批准号: 6727325
• 负责人: Anna N Yaroslavsky
• 金额: $ 32.12万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-20 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6727325
• 关键词: basal cell carcinoma; bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; clinical research; computer assisted diagnosis; computer program /software; fluorescence polarization; fluorescent dye /probe; human subject; image guided surgery /therapy; neoplasm /cancer classification /staging; neoplasm /cancer diagnosis; neoplasm /cancer invasiveness; noninvasive diagnosis; optical polarization; patient oriented research; squamous cell carcinoma

DESCRIPTION (provided by applicant): More than a million cases of non-melanoma skin cancers (i.e. basal cell and squamous cell carcinomas) are diagnosed every year. These cancers are more common than all other human cancers. Almost all basal cell and squamous cell carcinomas are curable by surgery if detected early. Unfortunately, in most cases the contrast of the lesions is poor, which complicates tumor localization and precise excision. Treatment of cancer patients could benefit greatly if a real-time non-invasive, reliable and cost-effective technique for delineating tumor margins were available. Therefore there is a strong need for practical, reliable, rapid, and precise methods for tumor localization, to guide surgery and other treatments of skin cancer. Once developed, such methods may potentially be useful for epithelial cancers of other organs. The overall goal of this proposal is to develop a practical way to detect skin cancer margins and guide tumor excision surgery using non-invasive optical imaging techniques. Specifically, spectrally resolved and polarization sensitive imaging methods and equipment, which are applicable for both reflectance and fluorescence imaging will be developed and implemented. The specific aims are: (i) Design and build multi-spectral polarization-enhanced reflectance and fluorescence imaging system for in vivo localization of skin cancers that can rapidly image large tumor affected areas in clinical setting. (ii) Develop methods for reliable localization of skin tumors based on polarized light reflectance imaging, dye enhanced polarized light reflectance imaging, and exogenous dye fluorescence-depolarization imaging. (iii) Develop and verify algorithms for quantitative assessment of skin tumor localization. (iv) Integrate the developed algorithms and imaging techniques into an efficient bedside guidance tool for tumor localization and excision. (v) Evaluate the clinical prototype and the developed imaging methods in a surgical practice environment.

描述(由申请人提供)： 每年诊断出100多万例非黑色素瘤皮肤癌(即基底细胞癌和鳞状细胞癌)。这些癌症比所有其他人类癌症更常见。如果及早发现，几乎所有的基底细胞癌和鳞状细胞癌都可以通过手术治愈。不幸的是，在大多数情况下，病变的对比度很差，这使得肿瘤的定位和精确切除变得复杂。如果有一种实时、非侵入性、可靠和成本效益高的技术来描绘肿瘤边缘，癌症患者的治疗将大大受益。因此，迫切需要实用、可靠、快速、准确的肿瘤定位方法，以指导皮肤癌的手术和其他治疗。一旦开发出来，这种方法可能会对其他器官的上皮性癌症有用。这项提案的总体目标是开发一种实用的方法来检测皮肤癌边缘，并使用非侵入性光学成像技术指导肿瘤切除手术。具体地说，将开发和实施既适用于反射成像又适用于荧光成像的光谱分辨率和偏振敏感成像方法和设备。具体目标是：(1)设计和构建多光谱偏振增强反射和荧光成像系统，用于皮肤癌的活体定位，能够在临床环境下快速成像大面积的肿瘤受累区域。(Ii)发展基于偏振光反射成像、染料增强偏振光反射成像和外源染料荧光-去偏振成像的皮肤肿瘤可靠定位方法。(Iii)开发和验证用于皮肤肿瘤定位的定量评估算法。(4)将开发的算法和成像技术集成到有效的床边指导工具中，用于肿瘤的定位和切除。(V)在外科实践环境中评估临床原型和开发的成像方法。