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Optical Mapping of Nonmelanoma Skin Cancers

非黑色素瘤皮肤癌的光学测绘

基本信息

批准号：
6943530
负责人：
Anna N Yaroslavsky
金额：
$ 34.67万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-20 至 2007-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6943530
关键词：
basal cell carcinoma bioimaging /biomedical imaging biomedical equipment development clinical biomedical equipment clinical research computer assisted diagnosis computer program /software fluorescence polarization fluorescent dye /probe human subject image guided surgery /therapy neoplasm /cancer classification /staging neoplasm /cancer diagnosis neoplasm /cancer invasiveness noninvasive diagnosis optical polarization patient oriented research squamous cell carcinoma

项目摘要

DESCRIPTION (provided by applicant): More than a million cases of non-melanoma skin cancers (i.e. basal cell and squamous cell carcinomas) are diagnosed every year. These cancers are more common than all other human cancers. Almost all basal cell and squamous cell carcinomas are curable by surgery if detected early. Unfortunately, in most cases the contrast of the lesions is poor, which complicates tumor localization and precise excision. Treatment of cancer patients could benefit greatly if a real-time non-invasive, reliable and cost-effective technique for delineating tumor margins were available. Therefore there is a strong need for practical, reliable, rapid, and precise methods for tumor localization, to guide surgery and other treatments of skin cancer. Once developed, such methods may potentially be useful for epithelial cancers of other organs. The overall goal of this proposal is to develop a practical way to detect skin cancer margins and guide tumor excision surgery using non-invasive optical imaging techniques. Specifically, spectrally resolved and polarization sensitive imaging methods and equipment, which are applicable for both reflectance and fluorescence imaging will be developed and implemented. The specific aims are: (i) Design and build multi-spectral polarization-enhanced reflectance and fluorescence imaging system for in vivo localization of skin cancers that can rapidly image large tumor affected areas in clinical setting. (ii) Develop methods for reliable localization of skin tumors based on polarized light reflectance imaging, dye enhanced polarized light reflectance imaging, and exogenous dye fluorescence-depolarization imaging. (iii) Develop and verify algorithms for quantitative assessment of skin tumor localization. (iv) Integrate the developed algorithms and imaging techniques into an efficient bedside guidance tool for tumor localization and excision. (v) Evaluate the clinical prototype and the developed imaging methods in a surgical practice environment.

描述（由申请人提供）：每年诊断出超过一百万例非黑色素瘤皮肤癌（即基底细胞癌和鳞状细胞癌）。这些癌症比所有其他人类癌症更常见。几乎所有的基底细胞癌和鳞状细胞癌如果早期发现都可以通过手术治愈。不幸的是，在大多数情况下，病灶的对比度很差，这使得肿瘤定位和精确切除变得复杂。如果能有一种实时、无创、可靠、经济的肿瘤边缘勾画技术，对癌症患者的治疗将大有益处。因此，迫切需要实用、可靠、快速和精确的肿瘤定位方法，以指导皮肤癌的手术和其他治疗。一旦开发出来，这种方法可能对其他器官的上皮癌有用。该提案的总体目标是开发一种实用的方法来检测皮肤癌边缘并使用非侵入性光学成像技术指导肿瘤切除手术。具体而言，将开发和实施适用于反射和荧光成像的光谱分辨和偏振敏感成像方法和设备。具体目标是：（i）设计和建造多光谱偏振增强反射和荧光成像系统，用于皮肤癌的体内定位，可以在临床环境中快速成像大的肿瘤受影响区域。(ii)开发基于偏振光反射成像、染料增强偏振光反射成像和外源性染料荧光去偏振成像的可靠皮肤肿瘤定位方法。(iii)开发和验证皮肤肿瘤定位定量评估的算法。(iv)将开发的算法和成像技术集成到一个有效的床边引导工具中，用于肿瘤定位和切除。(v)在手术实践环境中评估临床原型和开发的成像方法。