Portable Continuous Oxygen System

便携式连续供氧系统

• 批准号: 6694017
• 负责人: W SCOT APPEL
• 金额: $ 9.91万
• 依托单位: SEQUAL TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-04 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6694017
• 关键词: adsorption; bioengineering /biomedical engineering; biomedical equipment development; chronic obstructive pulmonary disease; hypoxia; miniature biomedical equipment; oxygen therapy; portable biomedical equipment

DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is a serious public health problem that is responsible for more than 500,000 hospitalizations, 100,000 deaths, and $15 billion in direct costs of medical care in the U.S. each year. In addition, millions of Americans are disabled by lung disease. It is estimated that more than 16 million people have undiagnosed COPD. Patients, whom have developed emphysema or obstructive bronchitis or who are afflicted with long-standing, low, blood-oxygen levels (chronic hypoxemia), typically require supplemental oxygen. Oxygen concentrators--electrically powered mechanical devices that extract oxygen from air by a process known as Pressure Swing Adsorption (PSA)--are the most prevalent devices used to provide supplemental oxygen (0.5 - 3.0 liters per minute). When low-flow supplemental oxygen is prescribed for the treatment of COPD or chronic hypoxemia, a patient is provided with a stationary oxygen concentrator for use in their home, plus several small tanks of gaseous oxygen and accessories (an oxygen conserving device & pressure regulator) for ambulation or excursions outside their home, including airline travel. SeQual Technologies has developed an advanced PSA gas separation system for the generation of oxygen for medical applications. This proprietary system incorporates a rapid vacuum-pressure-swing adsorption process that enables SeQual to provide a PSA unit with both the highest recovery (the ratio of output oxygen molecules to input oxygen molecules) and the greatest productivity (the oxygen output flow rate per unit volume of the system) of any medical oxygen concentrator. The Company's proprietary PSA devices--in combination with state-of-the-art, high efficiency, lightweight motors and compressors--have enabled SeQual to produce a unique, portable, battery-operated, oxygen concentrator system. SeQual's continued efforts remain in the improvement of the efficiency, productivity and recovery of oxygen molecules during the PSA process to effectively miniaturize the oxygen generation device that will lead to a very small scale portable oxygen concentrator that can deliver continuous oxygen to a patient at all times. The focus of this research is on novel monolithic structured adsorbents. The study proposes to characterize the surface area of the structures, study the effectiveness of the unique pressure swing adsorption cycles and parameters and design a very small system for the concentration of oxygen.

描述(由申请人提供)： 慢性阻塞性肺疾病(COPD)是一个严重的公共卫生问题，每年导致美国50多万人住院，10万人死亡，直接医疗费用高达150亿美元。此外，数百万美国人因肺部疾病而致残。据估计，有1600多万人患有未确诊的COPD。患有肺气肿或阻塞性支气管炎或长期存在低血氧水平(慢性低氧血症)的患者，通常需要补充氧气。氧气浓缩器是一种电动机械设备，通过变压吸附(PSA)过程从空气中提取氧气，是最常用的补充氧气的设备(每分钟0.5-3.0升)。当低流量补充氧气用于治疗慢性阻塞性肺病或慢性低氧血症时，患者会得到一个固定的氧气浓缩器，供他们在家中使用，外加几个小气态氧和附件(储氧器和压力调节器)，用于步行或外出旅行，包括航空旅行。Sequal Technologies开发了一种先进的PSA气体分离系统，用于产生医疗应用的氧气。这一专利系统结合了快速真空变压吸附过程，使SeQual能够为PSA装置提供任何医用氧气浓缩器中最高的回收率(输出氧气分子与输入氧气分子的比率)和最高的生产率(系统单位体积的氧气输出流量)。该公司专有的变压吸附设备--与最先进、高效、轻便的电机和压缩机相结合--使SeQual能够生产一种独特的便携式、电池供电的氧气浓缩系统。Sequal公司继续致力于提高PSA过程中氧气分子的效率、生产率和回收率，以有效地将氧气产生设备微型化，这将导致一种非常小规模的便携式氧气浓缩器，可以随时向患者输送持续的氧气。本研究的重点是新型整体式结构吸附剂。这项研究建议表征结构的表面积，研究独特的变压吸附循环和参数的有效性，并设计一个非常小的氧气浓缩系统。