Continuous Intraocular Pressure Sensing System

连续眼压传感系统

• 批准号: 6631115
• 负责人: ROBERT J KLINE-SCHODER
• 金额: $ 22.24万
• 依托单位: CREARE, LLC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6631115
• 关键词: biomedical equipment development; clinical biomedical equipment; diagnosis design /evaluation; glaucoma test; implant; intraocular pressure; miniature biomedical equipment; patient monitoring device; radiowave radiation; telemetry

Continuous monitoring of intraocular pressure would be a significant advance in management of glaucomateous patients. Continuous monitoring would allow the clinician to detect and quantify diurnal fluctuations in patients with progressive visual field loss. By optimizing control of lOP, retinal ganglion cell death will be mitigated, subsequent visual field deterioration will be less likely, and patients will have enhanced visual function and suffer less disability. Creare proposes to demonstrate the feasibility of a continuous intraocular pressure sensor in glaucoma patients who require cataract extraction. The innovation proposed is a pressure sensor that consists of a sensitive displacement transducer contained within a hermetic, biocompatible structure that can be implanted in the eye of a patient who requires a lens implant. The passive, resonant, implanted transducer absorbs RF energy from a detector coil outside of the patient at a frequency that is dependent on the intraocular pressure. Continuous measurements are collected and stored for later analysis by an attending physician. The Creare team has expertise in all of the areas required for the successful development of the intraocular pressure sensor, including the design and fabrication of microdevices, biomedical engineering, and clinical aspects of glaucoma care.

持续监测眼压将是眼压管理的重大进步 青光眼患者。连续监测将使临床医生能够检测和量化渐进性视野丧失患者的昼夜波动。通过优化 IOP 的控制，视网膜神经节细胞死亡将得到减轻，随后的视野恶化的可能性将降低，患者的视觉功能将得到增强并减少残疾。 Creare 提议证明连续眼压传感器在需要白内障摘除术的青光眼患者中的可行性。所提出的创新是一种压力传感器，由包含在密封、生物相容性结构内的敏感位移传感器组成，可以植入需要晶状体植入的患者的眼睛中。植入式无源谐振换能器以取决于眼压的频率吸收来自患者体外检测器线圈的射频能量。收集并存储连续测量结果以供主治医师稍后分析。 Creare 团队拥有成功开发眼压传感器所需的所有领域的专业知识，包括微型设备的设计和制造、生物医学工程以及青光眼护理的临床方面。