IN SITU, HIGH SPEED SCANNING ACOUSTIC MICROSCOPE

原位高速扫描声学显微镜

• 批准号: 6072502
• 负责人: ROBERT J KLINE-SCHODER
• 金额: $ 40.97万
• 依托单位: CREARE, LLC
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6072502
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical biomedical equipment; endoscopy; imaging /visualization /scanning; metal oxide; scanning electron microscopy

Scanning acoustic microscopes which operate at ultra-high frequencies (100-1000 MHz), permit the visualization of tissues on a microscopic scale similar to that provided by light nncroscopy, with the added benefit that the tissue sampie does not need to be biopsied. Potential clinical applications of acoustic microscopy include in situ imaging of cells on the skin, in the esophagus, in the colon, and in arteries. The goal of this project is to provide the practicing clinician with a tool to serve as an adjunct or replacement for physical biopsy procedures. Creare is working to complete the development of an innovative high speed, 200 MHz, scanning acoustic microscope for in situ imaging that employs a linear array of zinc oxide (ZnO) ultrasonic transducers which can be mounted in an endoscope, colonoscope, bronchoscope, laparoscope, or biopsy needle. Our Phase I results clearly demonstrate the feasibility of fabricating ultra high frequency ultrasonic transducer arrays. Creare fabricated 150 MHz transducer arrays, measured the acoustic performance of transducer elements, and performed the design of a prototype acoustic microscope for clinical use. During Phase II, Creare will package the array for use in important clinical applications and evaluate the utility of the device with extensive testing. PROPOSED COMMERCIAL APPLICATION: The proposed miniature scanning acoustic microscope will enable high resolution, in situ tissue characterization that we expect to serve as an adjunct to or replacement for tissue biopsy in performing pathological diagnosis. In addition, it has the potential to revolutionize the practice of nondestructive testing and evaluation for the semiconductor industry.

在超高频率（100-1000 MHz）下操作的扫描声学显微镜允许在类似于由光学显微镜提供的微观尺度上对组织进行可视化，具有不需要对组织样本进行活检的额外益处。声学显微镜的潜在临床应用包括皮肤、食道、结肠和动脉中细胞的原位成像。该项目的目标是为临床医生提供一种工具，作为物理活检程序的辅助或替代。Creare正在努力完成一种创新的高速，200 MHz，扫描声学显微镜的原位成像，采用氧化锌（ZnO）超声换能器的线性阵列，可以安装在内窥镜，结肠镜，支气管镜，腹腔镜，或活检针的发展。我们的第一阶段的结果清楚地证明了制造超高频超声换能器阵列的可行性。Creare制造了150 MHz换能器阵列，测量了换能器元件的声学性能，并设计了一个用于临床的原型声学显微镜。在第二阶段，Creare将包装该阵列用于重要的临床应用，并通过广泛的测试评估该设备的实用性。拟定商业应用：拟议的微型扫描声学显微镜将使高分辨率，原位组织表征，我们希望作为一种辅助或替代组织活检进行病理诊断。此外，它有可能彻底改变半导体行业的无损检测和评估实践。