Optical Cerebral Hemodynamics Monitor

描述（由申请人提供）：需要一种用于人类患者的脑血流动力学床边监测仪。近红外光谱（NIRS）是一种基于光学的技术，可以满足这种需求。采用无毒的近红外染料吲哚菁绿色（ICG）作为示踪剂，利用Fick原理，用近红外光谱法测量脑血流量（CBF）。然而，基于近红外光谱的脑血流动力学监测仪尚未广泛应用于临床常规监测。一个主要的挑战是开发一种光学探头和相应的算法，以解决成人近红外光谱应用中来自脑外组织（皮肤，头皮和头骨）的干扰问题。另一个挑战是开发一种简单准确的算法，该算法将能够量化动脉和大脑ICG浓度，这是使用Fick原理计算CBF所需的。我们的目标是解决这些挑战，开发一种具有集成探头的NIRS监测仪，可以同时测量动脉和真实脑组织的ICG浓度，以量化脑血流动力学。 本SBIR提案的主要目标是：设计和构建一个NIRS血流动力学监测系统;确定最佳的集成NIRS探头配置，以最大限度地减少脑组织ICG浓度测量的脑外干扰;并评估所提出的算法的可行性，并在动物模型中验证NIRS血流动力学参数。

DESCRIPTION (provided by applicant): There is a need for a bedside monitor of cerebral hemodynamics for human patients. Near-infrared spectroscopy (NIRS) is an optically based technique that could meet such demand. Using a non-toxic near infrared dye Indocyanine green (ICG) as a tracer, cerebral blood flow (CBF) can be measured with NIRS using the Fick principle. However, NIRS based cerebral hemodynamics monitor is not yet widely used in routine clinical monitoring. One major challenge is to develop an optical probe and a corresponding algorithm to solve the problem of interference from extracerebral tissue (skin, scalp, and skull) in adult NIRS applications. Another challenge is to develop a simple accurate algorithm that will be able to quantify the arterial and cerebral ICG concentrations, which are required for CBF calculation with the Fick principle. Our goal is to resolve these challenges to develop an NIRS monitor that has an integrated probe to simultaneously measure arterial and true brain tissue ICG concentrations for quantification cerebral hemodynamics. The primary objectives of this SBIR proposal are: Design and construct a NIRS hemodynamic monitoring the system; determine the optimum integrated NIRS probe configuration to minimize extracerebral interference of brain tissue ICG concentration measurement; and evaluate feasibility of proposed algorithms and validate NIRS hemodynamics parameters in animal models.