Adult Optical Non-Invasive Brain Oxygenation Monitor

描述(申请人提供)：需要一种非侵入性和连续的床边监测仪，用于成人患者的脑氧合。近红外光谱(NIRS)是一种基于光学的技术，可以满足这种需求。然而，近红外仪器尚未实现其最初预期的潜力，成为补充脉搏血氧仪的常规临床监测仪。一个主要的挑战是开发一种光学换能器探头和相应的算法来解决成人近红外应用中来自脑外组织(皮肤、头皮和头骨)的干扰问题。另一个主要挑战是开发一种算法，能够绝对量化光学信号，以得出具有临床意义的量化变量或指数。我们的目标是解决这些挑战，开发一种近红外监测仪，用于确定成年患者的绝对脑血红蛋白氧饱和度。这项SBIR建议的主要目标是：1)设计和构建用于成人患者的NIRS监护仪；2)确定最佳的成人NIRS探头配置，以最大限度地减少脑外干扰；3)评估和验证新的成人NIRS算法，进一步减少脑外干扰并确定绝对脑氧饱和度。

DESCRIPTION (provided by applicant): There is a need for a non-invasive and continuous bedside monitor for brain oxygenation for adult human patients. Near-infrared spectroscopy (NIRS) is an optically based technique that could meet such demand. However, NIRS instruments have yet to achieve their initially expected potential of becoming routine clinical monitors complementary to pulse oximetry. One major challenge is to develop an optical transducer probe and a corresponding algorithm to solve the problem of interference from extracerebral tissue (skin, scalp, and skull) in adult NIRS applications. Another major challenge is to develop an algorithm that will be able to absolutely quantify the optical signals to derive quantitative variables or indices that are of clinical significance. Our goal is to resolve these challenges to develop an NIRS monitor that will determine absolute brain hemoglobin oxygen saturation on adult patients. The primary objectives of this SBIR proposal are: 1) Design and construct an NIRS monitor for use on adult human patients; 2) Determine the optimum adult NIRS probe configuration to minimize extracerebral interference 3) Evaluate and validate novel adult NIRS algorithms that further minimize extracerebral interference and determine absolute brain oxygen saturation.