Computer Interview for Improving Human Rater Performance

描述(由申请人提供)：减少精神病学结果测量的可变性增强了统计能力，减少了临床试验的样本量要求，并降低了试验失败的可能性。Concordant Rater Systems(CRS)开发了一套基于计算机的评分员工具，包括交互式计算机面试(ICI)。这些患者自我报告工具的结果可以用来监控人类临床评分员的表现，这些工具利用一套专有算法来管理和评分Young Mania评定量表或其他衡量标准。在第一阶段，我们评估ICI的结构效度，以及它对少数民族人口、行业研究赞助商和精神病人的可接受性。我们还进行了一项初步研究，以评估ICI对评分者对症状敏感性的影响，获得评价者对其可接受性的反馈，并建立在第二阶段进行多中心临床试验设计所需的效果大小估计。统计分析和市场研究表明，提高评分者一致性的能力将对进行精神病学临床试验的制药公司或临床研究组织具有价值。作为一家将评分员培训方面的重要专业知识与基于互联网的教育内容提供相结合的公司，CRS处于有利地位，可以开发和实施这些创新技术。

DESCRIPTION (provided by applicant): Decreasing variability in psychiatric outcome measures augments statistical power, reduces sample size requirements for clinical trials, and reduces the likelihood of failed trials. Concordant Rater Systems (CRS) has developed a suite of computer-based rater tools, including Interactive Computer Interviews (ICI). Results from these patient self-report tools, which utilize a set of proprietary algorithms to administer and score the Young Mania Rating Scale or other measures, can be used to monitor the performance of human clinical raters. In Phase I, we assess the construct validity of the ICI as well as its acceptability to ethnic minority populations, industry study sponsors, and psychiatric patients. We also conduct a pilot study to assess the effect of the ICI on rater sensitivity to symptoms, obtain feedback from raters on its acceptability, and establish effect size estimates needed for design of multi-center clinical trials to be conducted in Phase II. Statistical analyses and market research suggest that the ability to improve rater concordance will be valuable to pharmaceutical companies or clinical research organizations that conduct clinical trials in psychiatry. As a company combining significant expertise in rater training with delivery of internet-based educational content, CRS is well positioned to develop and implement these innovative technologies.