Small Field of View Gamma Camera for Scintimammography

用于闪烁X线摄影的小视场伽马相机

• 批准号: 6830055
• 负责人: MICHAEL K O'CONNOR
• 金额: $ 17.26万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-27 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6830055
• 关键词: automated data processing; bioimaging /biomedical imaging; biomedical equipment development; biopsy; breast neoplasm /cancer diagnosis; clinical biomedical equipment; clinical research; clinical trials; computer program /software; computer simulation; computer system design /evaluation; diagnosis design /evaluation; human subject; image enhancement; mammography; method development; patient oriented research; scintillation cameras

DESCRIPTION (provided by applicant) Scintimammography was developed in the mid-1990s with the hope that it would become a useful diagnostic tool for breast cancer. Over the last 8 years, multiple studies have shown that while it has a very high overall sensitivity ( approximately 85%), this value drops to 50% or less for the detection of lesions C 10-15 mm in diameter. Dedicated small field of view gamma cameras show promise for the detection of small (<10mm) lesions in the breast. However, this technology is in its infancy and many technical questions on the optimal design of these systems remain. The purpose of this proposal is to develop and evaluate a clinically robust imaging system that will provide reliable detection of sub-10 mm lesions in the breast. The prototype gamma camera is a 20 cm x 20 cm semiconductor-based gamma camera utilizing modules of Cadmium-Zinc-Telluride. We plan to a) optimize the technical aspects of breast imaging, through improvement in energy resolution, collimation, and gantry design, b) perform clinical studies to determine the limits of lesion detection and the incremental value (if any) of a dual-head system, c) develop techniques for localization and biopsy of lesions by incorporating into the gantry design a breast ultrasound system that will permit simultaneous acquisition of scintigraphic and ultrasound data, and d) develop software to permit co-registration of the scintigraphic and ultrasound data. These latter goals are particularly important for lesions that are seen on scintimammography, but not visible on conventional mammograms. While many investigators have stated that a small detector is required for scintimammography, we believe that this is only the first stage in the development of a clinically useful system. Optimization of the gantry and performance characteristics of small field of view detectors, and providing a means of IocaIizing lesions, are critical to the migration of this technology from research into clinical practice.

描述（由申请人提供） 羊膜摄影是在1990年代中期开发的，希望它成为乳腺癌的有用诊断工具。在过去的8年中，多项研究表明，尽管它具有很高的总体灵敏度（约为85％），但对于检测病变C 10-15 mm的直径为10％或更少。专用的小型视野伽玛相机表明有望发现乳房中的小（<10mm）病变。但是，这项技术仍处于起步阶段，并且有关这些系统最佳设计的许多技术问题仍然存在。该提案的目的是开发和评估临床上强大的成像系统，该系统将可靠地检测到乳房中的10 mM病变。原型伽马摄像头是20厘米x 20厘米半导体的伽马摄像头，利用镉 - 泰氏纤维模块的模块。我们计划a）通过改进能量分辨率，准确性和龙门设计来优化乳房成像的技术方面，b）执行临床研究，以确定病变检测的限制以及双杆系统的增量价值（如果任何双杆系统），c）通过将术语纳入术语的范围，以使乳房的设计将术语纳入术语和生物效果，从而将术语纳入术语，从而将乳房的系统纳入术语，从而将乳房的效果纳入术语，以使术语刻板地融合到术中，以实现术语和术语。超声数据和d）开发软件以允许共同注册闪烁图和超声数据。这些后一个目标对于在闪烁剧摄影上看到但在常规乳房X线照片上看不见的病变尤为重要。尽管许多研究人员表示，羊膜摄影需要一个小的检测器，但我们认为这只是临床上有用系统开发的第一阶段。小型视野检测器的龙门和性能特征的优化以及提供iocai化病变的手段对于从研究到临床实践的迁移至关重要。