Monochromatic Phase-Contrast Breast Cancer Radiography

单色相差乳腺癌放射线摄影

• 批准号: 6810205
• 负责人: EDWIN F DONNELLY
• 金额: $ 16.99万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6810205
• 关键词: X ray; bioimaging /biomedical imaging; biomedical equipment development; breast neoplasm /cancer diagnosis; clinical biomedical equipment; clinical research; human tissue; image enhancement; mammography; method development; neoplasm /cancer radiodiagnosis; phase contrast microscopy; radiation dosage; radiography; women' s health

DESCRIPTION (provided by applicant): The Department of Radiology and Radiological Sciences at Vanderbilt University Medical Center has been investigating polychromatic phase-contrast radiography (PC-R) for several years. This technique has many potential uses in medical imaging as a new contrast mechanism for soft tissue imaging. Unlike laboratories utilizing a Synchroton light source (which will not be available for routine medical facilities), our technique utilizes the concept of spatial coherence, rather than temporal coherence, to obtain images strongly influenced by phase effects. The major limitation of the technique is the low tube output of the microfocal X-ray tube needed for PC-R. This project proposes to partner the investigators in Radiology who have been developing PC-R techniques with an X-ray source available at the Free Electron Laboratory (FEL) facility located on the Vanderbilt campus through a new collaboration between physicists at the FEL laboratory and the imaging researchers in the PC-R laboratory. The newly-developed X-ray source is completely independent of the Free Electron Laser itself and has been designed to function as a "table-top" source that could be generally available to medical facilities. The X-ray beam produced by this source is largely monochromatic and has an extremely high spatial coherence. In addition, it has been designed to provide a high X-ray flux. These 3arameters make it a nearly-ideal source for PC-R. The project will initially optimize the imaging parameters for monochromatic PC-R with the unique X-ray source, by investigating different geometries and energies. Once the technique has been optimized, monochromatic PC-R will be compared to absorption radiography (with both the monochromatic source and with a traditional mammography machine) on surgical breast specimens. Image quality of all images will be judged by an experienced mammographer.

描述（由申请人提供）： 范德比尔特大学医学中心放射学和放射科学系多年来一直在研究多色相差放射成像 (PC-R)。该技术作为软组织成像的新对比机制在医学成像中具有许多潜在用途。与使用同步光源的实验室（常规医疗设施无法使用）不同，我们的技术利用空间相干性的概念，而不是时间相干性，来获取受相位效应强烈影响的图像。该技术的主要限制是 PC-R 所需的微焦 X 射线管的管输出较低。 该项目提议与放射学研究人员合作，通过 FEL 实验室的物理学家和 PC-R 实验室的成像研究人员之间的新合作，利用范德比尔特校园自由电子实验室 (FEL) 设施中的 X 射线源开发 PC-R 技术。新开发的 X 射线源完全独立于自由电子激光器本身，并被设计为可普遍用于医疗机构的“桌面”源。该源产生的 X 射线束大部分是单色的，并且具有极高的空间相干性。此外，它还设计用于提供高 X 射线通量。这 3 个参数使其成为 PC-R 近乎理想的来源。 该项目最初将通过研究不同的几何形状和能量，利用独特的 X 射线源优化单色 PC-R 的成像参数。一旦技术得到优化，单色 PC-R 将与手术乳腺标本上的吸收射线照相术（使用单色源和传统的乳房 X 线摄影机）进行比较。所有图像的图像质量将由经验丰富的乳房X线照相技师进行判断。