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Hemodynamic Imaging for Brain Tumor Prognosis

血流动力学成像用于脑肿瘤的预后

基本信息

批准号：
6767758
负责人：
HANLI LIU
金额：
$ 14.25万
依托单位：
UNIVERSITY OF TEXAS ARLINGTON
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-07-01 至 2005-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): It is crucial and advantageous if tumors under therapy can be functionally monitored and imaged at different treatment stages. A non-invasive, portable, cost-effective, in vivo imaging tool is much needed to choose, guide and follow cancer therapy. The overall objective of this phased proposal is to develop such a novel imaging modality by utilizing Near Infrared (NIR) tomography in combination with hemodynamic modeling to functionally obtain hemodynamic images of animal brain tumors, which are under radio-surgery with and without respiratory interventions. The tomographic images of changes in hemoglobin concentrations, blood flow, and oxygen consumption rate of the brain tumor caused by different radiation doses in radio-surgery along with hyperoxic interventions can be obtained non-invasively and chronically. Such hemodynamic images may provide prognostic information, for clinical radio-surgery practice, on inhomogeneous responses of the tumor to the therapy and intervention as well as on the effectiveness of the therapy. There are three specific aims in the R21 phase: (1) to design and implement an 8-source, 8- detector, NIR spectroscopic imager suitable for dynamic rat brain imaging of oxygenated hemoglobin concentration and total hemoglobin concentration (HbO, HbT), (2) to develop a 2D tomographic reconstruction algorithm and to obtain 2D dynamic tomography of vascular oxygenation under different oxygen interventions using rat brain tumor phantoms, and (3) to develop and validate, through hemodynamic phantom experiments, mathematical models to quantitatively associates the blood flow (BF) and oxygen consumption rate (O2CR) of the tumor to its HbO and HbT determined by the NIR spectroscopic measurements. After success of the initial R21 development, three specific aims in the R33 phase are: (1) to validate 2D tomographic images of the BF and O2CR using dynamic tumor phantoms, (2) to obtain dynamic images of respiratory-induced changes in HbO, HbT, BF, and O2CR from rat brain tumors (9L Gliosarcoma) before and after radiation therapy with and without carbogen intervention during radiation, and (3) to investigate heterogeneous response of the brain tumors to the intervention and to the radio surgery and to examine the prognostic value of the hemodynamic parameters (Hb, HbO, BF, and O2CR) for the radiation therapy by comparing with the histological analysis of the corresponding tumors.

描述（由申请人提供）：如果治疗中的肿瘤可以在不同的治疗阶段进行功能监测和成像，这是至关重要的和有利的。一个非侵入性的，便携式的，具有成本效益的，在体内成像工具是非常需要的选择，指导和遵循癌症治疗。该分阶段提案的总体目标是通过利用近红外（NIR）断层扫描结合血流动力学建模来开发这样一种新型成像模式，以功能性地获得动物脑肿瘤的血流动力学图像，该动物脑肿瘤在有和没有呼吸干预的情况下接受放射外科手术。放射外科沿着高氧介入治疗中不同辐射剂量引起的脑肿瘤血红蛋白浓度、血流量和耗氧率变化的断层图像可以无创地和长期地获得。这样的血液动力学图像可以为临床放射外科实践提供关于肿瘤对治疗和干预的不均匀反应以及关于治疗的有效性的预后信息。R21阶段有三个具体目标：（1）设计并实现一种8源、8检测器、NIR光谱成像仪，适用于氧合血红蛋白浓度和总血红蛋白浓度的动态大鼠脑成像（HbO，HbT），（二）开发二维断层重建算法，并获得不同氧干预下大鼠脑血管氧合的二维动态断层成像肿瘤模型，以及（3）通过血液动力学模型实验，开发和验证数学模型，以定量地将肿瘤的血流量（BF）和氧消耗速率（O2CR）与通过NIR光谱测量确定的其HbO和HbT相关联。在R21初步开发成功后，R33阶段的三个具体目标是：（1）使用动态肿瘤模型验证BF和O2CR的2D断层摄影图像，（2）获得大鼠脑肿瘤中HbO、HbT、BF和O2CR的断层摄影诱导变化的动态图像（9L胶质肉瘤）在放射治疗前后，在放射期间有和没有碳干预，（3）探讨脑肿瘤对介入治疗和放射外科治疗的异质性反应，并探讨血流动力学参数的预后价值（Hb、HbO、BF、O2CR）与相应肿瘤的组织学分析进行比较。